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Byeon, Jung Hye,Kim, Gun-Ha,Kim, Joo Yeon,Sun, Woong,Kim, Hyun,Eun, Baik-Lin The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.46 No.4
Objective : Perinatal hypoxic-ischemic encephalopathy (HIE) and prolonged febrile seizures (pFS) are common neurologic problems that occur during childhood. However, there is insufficient evidence from experimental studies to conclude that pFS directly induces hippocampal injury. We studied cognitive function and histological changes in a rat model and investigated which among pFS, HIE, or a dual pathologic effect is most detrimental to the health of children. Methods : A rat model of HIE at postnatal day (PD) 7 and a pFS model at PD10 were used. Behavioral and cognitive functions were investigated by means of weekly open field tests from postnatal week (PW) 3 to PW7, and by daily testing with the Morris water maze test at PW8. Pathological changes in the hippocampus were observed in the control, pFS, HIE, and HIE+pFS groups at PW9. Results : The HIE priming group showed a seizure-prone state. The Morris water maze test revealed a decline in cognitive function in the HIE and HIE+pFS groups compared with the pFS and control groups. Additionally, the HIE and HIE+pFS groups showed significant hippocampal neuronal damage, astrogliosis, and volume loss, after maturation. The pFS alone induced minimal hippocampal neuronal damage without astrogliosis or volume loss. Conclusion : Our findings suggest that pFS alone causes no considerable memory or behavioral impairment, or cellular change. In contrast, HIE results in lasting memory impairment and neuronal damage, gliosis, and tissue loss. These findings may contribute to the understanding of the developing brain concerning conditions caused by HIE or pFS.
변혜성 ( Hye-sung Byeon ),오태진 ( Tae-jin Oh ),정민규 ( Min-gyu Jung ),정영진 ( Yeong-jin Jung ),김웅섭 ( Woongsup Kim ) 한국정보처리학회 2019 한국정보처리학회 학술대회논문집 Vol.26 No.2
본 설계는 청각장애인을 위한 기술이다. 청각장애인은 일상생활에서 음성을 통한 의사소통이 어렵기 때문에, 비장애인과의 정보 격차를 줄이기 위한 ‘안경 부착형 커뮤니케이션 디바이스’를 개발하였다. Speech-To-Text 기술을 적용하여 음성이 인식되면 텍스트로 변환하여 출력한다. 따라서 음성에 대한 정보를 텍스트로 볼 수 있게끔 구현하였다. 또한 청각장애인은 소리로 파악할 수 있는 위험 요소에 노출되어 있다. 혹시 모를 안전사고에 빠르게 대처하고자 현재 위치 정보를 보호자에게 전송하는 기능을 구현하였다.
Moo-Geun Jee,Hye-Jung Lee,Mingmao Sun,Sailila E. Abdula,Sanguk Byeon,Dal-A Yu,Yu-Jin Jung,Kwon-Kyoo Kang,Illsup Nou,Yong-Gu Cho 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07
Amylopectin composition is determined by the relative activity of soluble starch synthase (SSS) and granule-bound starch synthase (GBSS). Soluble starch synthase and starch branching enzymes are major determinants for the synthesis of amylopectin while GBSS1 is responsible for amylose synthesis in vivo. The formers are made of linear and branched molecules and the latter is composed of highly branched molecules. To increase the palatability of rice, down-regulation of amylose synthesis by antisense and RNA interference (RNAi) could be excellent and powerful tools for controlling the starch composition which is responsible for grain eating quality. The goal of this study is to generate breeding lines with lower amylose content relative to its wild type. This study also reports the results of the two down-regulating technology in lowering the amylose content of rice grain. Furthermore, this study elucidates the effect of using antisense and RNAi for SSS1 and GBSS1.
Ictal sinus pause and myoclonic seizure in a child
Hye Ryun Kim,Gun-Ha Kim,So-Hee Eun,Baik-Lin Eun,Jung Hye Byeon 대한소아청소년과학회 2016 Clinical and Experimental Pediatrics (CEP) Vol.59 No.no.sup1
Ictal tachycardia and bradycardia are common arrhythmias; however, ictal sinus pause and asystole are rare. Ictal arrhythmia is mostly reported in adults with temporal lobe epilepsy. Recently, ictal arrhythmia was recognized as a major warning sign of sudden unexpected death in epilepsy. We present an interesting case of a child with ictal sinus pause and asystole. A 27-month-old girl was hospitalized due to 5 episodes of convulsions during the past 2 days. Results of routine electroencephalography (EEG) were normal, but she experienced brief generalized tonic seizure for 3 days. During video-monitored EEG and echocardiography (ECG), she showed multiple myoclonic seizures simultaneously or independently, as well as frequent sinus pauses. After treatment with valproic acid, myoclonus and generalized tonic seizures were well controlled and only 2 sinus pauses were seen on 24-hour Holter ECG monitoring. Sinus dysfunction should be recognized on EEG, and it can sometimes be treated successfully with only antiepileptic medication.
Systematic review of published data on herb induced liver injury
Byeon, Jung-Hwan,Kil, Ji-Hye,Ahn, Yo-Chan,Son, Chang-Gue Elsevier 2019 Journal of Ethnopharmacology Vol.233 No.-
<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P>Herbal products have been widely used as a means of ethnomedicine worldwide. Recently, the potential hepatotoxicity of herbs has become a medical issue but comprehensive studies are limited.</P> <P><B>Aim of the study</B></P> <P>This study aims to determine the clinical features of herb induced liver injury (HILI) including its constituent ratio among liver injury case cohorts that included both HILI and drug induced liver injury (DILI).</P> <P><B>Materials and methods</B></P> <P>A systematic review was conducted using a literature search for DILI/HILI in seven electric databases including PubMed, Cochrane and Embase. We analyzed the DILI/HILI cases and clinical characteristics in terms of herbs, conventional drugs, concomitant, or others.</P> <P><B>Results</B></P> <P>Thirty-one studies met the necessary criteria and included 9 prospective and 22 retrospective studies. Among total number of overall DILI/HILI cases (7511, male 2819, female 3669 and unknown 1023), 25.0% (1874 cases) were implicated in herbs. HILI was relatively higher in females (69.8% <I>vs</I>. 30.2% male), compared to conventional drugs (57.3% female <I>vs</I>. 42.7% male, p < 0.01), while it was prone to induce hepatocellular injury (hepatocellular 78.8%, cholestatic 8.9%, mixed type 12.3%), contrary to conventional drugs (hepatocellular 56.7% <I>vs</I>. cholestatic 22.1% <I>vs</I>. mixed 21.2%), respectively (p < 0.01). The main herbs causing HILI included <I>Polygonum multiflorum, Psoralea corylifolia, Corydalis yanhusuo,</I> and <I>Rheum officinale.</I> </P> <P><B>Conclusions</B></P> <P>This review created the comparative and comprehensive feature of hepatotoxicity by herbal products, which provides reference data for the clinical applications and establishing pharmacovigilance system of herbs.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Strongly increased exposure of meloxicam in CYP2C9*3/*3 individuals
Lee, Hye-In,Bae, Jung-Woo,Choi, Chang-Ik,Lee, Yun-Jeong,Byeon, Ji-Yeong,Jang, Choon-Gon,Lee, Seok-Yong Wolters Kluwer Health | Lippincott Williams Wilkin 2014 PHARMACOGENETICS AND GENOMICS Vol.24 No.2
OBJECTIVE: The effects of CYP2C9*1/*3 and *3/*3 genotypes on the pharmacokinetics and pharmacodynamics of meloxicam were evaluated in healthy Korean subjects. METHODS: After oral administration of 15 mg meloxicam, the plasma concentrations of meloxicam were assessed in 11 CYP2C9*1/*1 individuals, eight CYP2C9*1/*3 individuals, and three CYP2C9*3/*3 individuals. The pharmacodynamic effects were determined by measuring thromboxane B2 generated in blood. RESULTS: A nine-fold lower apparent oral clearance and an eight-fold higher AUC0–∞ of single-dose meloxicam were observed in CYP2C9*3/*3 individuals when compared with CYP2C9*1/*1 individuals. CYP2C9*3/*3 individuals also showed markedly increased inhibition of thromboxane B2 generation by meloxicam. CONCLUSION: These results indicate that CYP2C9*3/*3 individuals may be at a higher risk for concentration-dependent adverse effects during long-term treatment with standard doses of meloxicam.
Ictal sinus pause and myoclonic seizure in a child
Kim, Hye Ryun,Kim, Gun-Ha,Eun, So-Hee,Eun, Baik-Lin,Byeon, Jung Hye The Korean Pediatric Society 2016 Clinical and Experimental Pediatrics (CEP) Vol.59 No.no.sup1
Ictal tachycardia and bradycardia are common arrhythmias; however, ictal sinus pause and asystole are rare. Ictal arrhythmia is mostly reported in adults with temporal lobe epilepsy. Recently, ictal arrhythmia was recognized as a major warning sign of sudden unexpected death in epilepsy. We present an interesting case of a child with ictal sinus pause and asystole. A 27-month-old girl was hospitalized due to 5 episodes of convulsions during the past 2 days. Results of routine electroencephalography (EEG) were normal, but she experienced brief generalized tonic seizure for 3 days. During video-monitored EEG and echocardiography (ECG), she showed multiple myoclonic seizures simultaneously or independently, as well as frequent sinus pauses. After treatment with valproic acid, myoclonus and generalized tonic seizures were well controlled and only 2 sinus pauses were seen on 24-hour Holter ECG monitoring. Sinus dysfunction should be recognized on EEG, and it can sometimes be treated successfully with only antiepileptic medication.