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Kim, Juhye,Cha, Sunyeong,Lee, Min Young,Hwang, Yeon Jeong,Yang, Eunhyeok,Ryou, Chongsuk,Jung, Hyo-Il,Cheon, Yong-Pil The Korean Society of Developmental Biology 2018 발생과 생식 Vol.22 No.4
Through the development of organic synthetic skill, chemicals that mimic signaling mediators such as steroid hormones have been exposed to the environment. Recently, it has become apparent that this circumstance should be further studied in the field of physiology. Estrogenic action of chronic low-dose nonylphenol (NP) and di-(2-ethylhexyl) phthalate (DEHP) in mouse uterus was assessed in this study. Ten to twelve-week-old female mice (CD-1) were fed drinking water containing NP (50 or $500{\mu}g/L$) or DEHP (133 or $1,330{\mu}g/L$) for 10 weeks. Uterine diameter, the thickness of myometrium and endometrium, and the height of luminal epithelial cells were measured and the number of glands were counted. The expression levels of the known $17{\beta}$-estradiol ($E_2$)-regulated genes were evaluated with real-time RT-PCR methodology. The ration of uterine weight to body weight increased in $133{\mu}g/L$ DEHP. Endometrial and myometrial thickness increased in 133 and $1,330{\mu}g/L$ DEHP treated groups, and in 50, $500{\mu}g/L$ NP and $133{\mu}g/L$ DEHP, respectively. The height of luminal epithelial cell decreased in NP groups. The numbers of luminal epithelial gland were decreased in NP groups but increased in $50{\mu}g/L$ DEHP group. The histological characters of glands were not different between groups. The mRNA expression profiles of the known $17{\beta}$-estradiol ($E_2$) downstream genes, Esr1, Esr2, Pgr, Lox, and Muc1, were also different between NP and DEHP groups. The expression levels dramatically increased in some genes by the NP or DEHP. Based on these results, it is suggested that the chronic low-dose NP or DEHP works as estrogen-like messengers in uterus with their own specific gene expression-regulation patterns.
Kim, Juhye,Cha, Sunyeong,Lee, Min Young,Hwang, Yeon Jeong,Yang, Eunhyeok,Choi, Donchan,Lee, Sung-Ho,Cheon, Yong-Pil The Korean Society of Developmental Biology 2019 발생과 생식 Vol.23 No.3
Based on our preliminary results, we examined the possible role of low-dose and chronic-exposing of the chemicals those are known as endocrine disrupting chemical (EDC), on the proliferation of uterine endometrium and the localization of steroid receptors. Immunohistochemical or immunofluorochemical methodology were employed to evaluate the localization of antigen identified by monoclonal antibody Ki 67 protein (MKI67), estrogen receptor 1 (ESR1), estrogen receptor 2 (ESR2), and progesterone receptor (PGR). In $133{\mu}g/L$ and $1,330{\mu}g/L$ di(2-ethylhexyl) phthalate (DEHP) and $50{\mu}g/L$ nonylphenol (NP) groups, the ratio of MKI67 positive stromal cells was significantly increased but not in $500{\mu}g/L$ NP group. The ratios of MKI67 positive glandular and luminal epithelial cells were also changed by the chronic administration of NP and DEHP in tissue with dose specific manner. ESR1 signals were localized in nucleus in glandular and luminal epithelia of control group but its localization was mainly in cytoplasm in DEHP and NP administered groups. On the other hand, it was decreased at nucleus of stromal cells in $1,330{\mu}g/L$ DEHP group. The colocalization patterns of these nuclear receptors were also modified by the administration of these chemicals. Such a tissue specific and dose specific localization of ESR2 and PGR were detected as ESR1 in all the uterine endometrial tissues. These results show that the chronic lows-dose exposing of NP or DEHP modify the localization and colocalization of ESRs and PGR, and of the proliferation patterns of the endometrial tissues.
Kim, Juhye,Park, Kwangwoo,Yoon, Jeongmin,Lee, Eungman,Cho, Samju,Ahn, Sohyun,Park, Jeongeun,Choi, Wonhoon,Lee, Ho Korean Society of Medical Physics 2016 의학물리 Vol.27 No.4
This paper aims to verify the clinical feasibility of a custom-made film created by a laser cutting tool for End-to-End (E2E) quality assurance in robotic intensity modulated radiation therapy system. The custom-made film was fabricated from the Gafchromic EBT3 film with the size of $8^{{\prime}{\prime}}{\times}10^{{\prime}{\prime}}$ using a drawing that is identical to the shape and scale of the original E2E film. The drawing was created by using a computer aided design program with the image file, which is obtained by scanning original E2E film. Beam delivery and evaluations were respectively performed with the original film and the custom-made film using fixed-cone collimator on three tracking modes: 6D skull (6DS), Xsight spine (XS), and Xsight lung (XL). The differences between total targeting errors of the original and custom-made films were recorded as 0.17 mm, 0.3 mm, and 0.17 mm at 6DS, XS, and XL tracking modes, respectively. This indicates that the custom-made film could yield nearly equivalent results to those of the original E2E film, given the uncertainties caused by distortions during film scanning and vibrations associated with film cutting. By confirming the clinical feasibility of a custom-made film for E2E testing, it can be expected that economic efficiency of the testing will increase accordingly.
Zinc sensors with lower binding affinities for cellular imaging
Kim, Jin Hoon,Hwang, In Hong,Jang, Seung Pyo,Kang, Juhye,Kim, Sumi,Noh, Insup,Kim, Youngmee,Kim, Cheal,Harrison, Roger G. The Royal Society of Chemistry 2013 Dalton transactions Vol.42 No.15
<P>Zinc sensors based on 2,3-dipicolylamine (DPA) and quinoline have been synthesized. They fluoresced in the presence of Zn<SUP>2+</SUP> and remained fluorescent when other metal ions were present. Fluorescence enhancement of the sensors was not seen for most other metal ions. <I>In vitro</I> studies with fibroblasts showed fluorescence when sensor and Zn<SUP>2+</SUP> were present. As seen by single crystal X-ray analysis, four nitrogens from the sensor bind to Zn<SUP>2+</SUP>. These new sensors have lower binding constants than the pentadentate sensors based on 2,2-DPA.</P> <P>Graphic Abstract</P><P>Molecules based on quiniline and bispicolylamine selectively bind Zn<SUP>2+</SUP> ions, fluoresce and cause fluorescence in cells exposed to Zn<SUP>2+</SUP>. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3dt33024a'> </P>
Kim Sunghee,Lee Eunbi,Park Juhye,Nam Ju-Ock,Kim Soo Rin 한국미생물·생명공학회 2024 Journal of microbiology and biotechnology Vol.34 No.6
Citrus fruits offer a range of health benefits due to their rich nutritional profile, including vitamin C, flavonoids, carotenoids, and fiber. It is known that unripe citrus has higher levels of vitamin C, dietary fiber, polyphenols, and flavonoids compared to mature fruits. In this study, we assessed the nutritional components of unripe citrus peel and pressed juices, as well as their anti-obesity potential through the modulation of adipocyte differentiation and the expression of adipogenesisrelated genes, specifically PPARγ and C/EBPα, in 3T3-L1 preadipocytes. Our analysis revealed that unripe citrus peel exhibited elevated levels of fiber and protein compared to pressed juice, with markedly low levels of free sugar, particularly sucrose. The content of hesperidin, a representative flavonoid in citrus fruits, was 3,157.6 mg/kg in unripe citrus peel and 455.5 mg/kg in pressed juice, indicating that it was approximately seven times higher in unripe citrus peel compared to pressed juice. Moreover, we observed that the peel had a dose-dependently inhibitory effect on adipocyte differentiation, which was linked to a significant downregulation of adipogenesis-related gene expression. Thus, our findings suggest that unripe citrus possesses anti-obesity effects by impeding adipogenesis and adipocyte differentiation, with the peel demonstrating a more pronounced effect compared to pressed juice.
Analysis of spray nozzle in 1-channel MQL (minimum quantity lubrication) systems
Juhye Shin,Axel Lefebure,Se Eun Kim,Doyeon Weon,Gwanghun Jeon,Yunseo Kang,Hajin Park,Jumi Lee,Deukgwi Lee,Changsu Lee,Yeongchang Park,Kyeongdong Kim,Sangyeop Lee,Dongha Shim 한국생산제조학회 2020 한국생산제조시스템학회 학술발표대회 논문집 Vol.2020 No.10
Kim, Juhye,Shin, Dong Oh,Choi, Sang Hyoun,Min, Soonki,Kwon, Nahye,Jung, Unjung,Kim, Dong Wook Korean Society of Medical Physics 2018 의학물리 Vol.29 No.4
The complex dose distribution and dose transfer characteristics of intensity-modulated radiotherapy increase the importance of precise beam data measurement and review in the acceptance inspection and preparation stages. In this study, we propose a process map for the introduction and installation of high-precision radiotherapy devices and present items and guidelines for risk management at the acceptance test procedure (ATP) and commissioning stages. Based on the ATP of the Varian and Elekta linear accelerators, the ATP items were checked step by step and compared with the quality assurance (QA) test items of the AAPM TG-142 described for the medical accelerator QA. Based on the commissioning procedure, dose quality control protocol, and mechanical quality control protocol presented at international conferences, step-by-step check items and commissioning guidelines were derived. The risk management items at each stage were (1) 21 ionization chamber performance test items and 9 electrometer, cable, and connector inspection items related to the dosimetry system; (2) 34 mechanical and dose-checking items during ATP, 22 multileaf collimator (MLC) items, and 36 imaging system items; and (3) 28 items in the measurement preparation stage and 32 items in the measurement stage after commissioning. Because the items presented in these guidelines are limited in terms of special treatment, items and practitioners can be modified to reflect the clinical needs of the institution. During the system installation, it is recommended that at least two clinically qualified medical physicists (CQMP) perform a double check in compliance with the two-person rule. We expect that this result will be useful as a radiation safety management tool that can prevent radiation accidents at each stage during the introduction of radiotherapy and the system installation process.
Kim, Ayoung,Jung, Hojae,Song, Juhye,Kim, Hyun Jong,Jeong, Goojin,Kim, Hansu American Chemical Society 2019 ACS APPLIED MATERIALS & INTERFACES Vol.11 No.9
<P>Herein, we have identified that lithium ions in an SO<SUB>2</SUB>-based inorganic electrolyte reversibly intercalate and deintercalate into/out of graphite electrode using ex situ X-ray diffraction and various electrochemical methods. X-ray photoelectron spectroscopy shows that the solid electrolyte interphase on the graphite electrode is mainly composed of inorganic compounds, such as LiCl and lithium sulfur-oxy compounds. Graphite electrode in SO<SUB>2</SUB>-based inorganic electrolyte has stable capacity retention up to 100 cycles and outstanding rate capability performance. This can be attributed to low interfacial impedance and high ionic conductivity of SO<SUB>2</SUB>-based inorganic electrolyte, which are superior to those of conventional organic electrolytes. Considering the remarkable rate capability and intrinsically nonflammable properties of the electrolyte, use of graphite and an SO<SUB>2</SUB> electrolyte will likely facilitate the development of advanced lithium-ion batteries.</P> [FIG OMISSION]</BR>