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A Promising Serum Autoantibody Marker, Anti-Heat Shock Protein 90α, for Cholangiocarcinoma
Boonjaraspinyo, Sirintip,Juasook, Amornrat,Boonmars, Thidarut,Aukkanimart, Ratchadawan,Silsirivanit, Atit,Loilome, Watcharin,Sriraj, Pranee,Wu, Zhiliang,Ratanasuwan, Panaratana Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14
The present study was designed to investigate cholangiocarcinoma (CCA) antibodies in hamster serum. Hamster CCA cell lines were processed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. A candidate biomarker was confirmed by immunoprecipitation and western blot, and was further analyzed using ELISA and sera from normal control hamsters, hamsters with opisthorchiasis and hamsters with various stages of CCA, as well as from CCA patients and healthy individuals. One candidate marker was identified as $HSP90{\alpha}$, as indicated by a high level of anti-$HSP90{\alpha}$ in hamster CCA sera. It was found that the levels of anti-$HSP90{\alpha}$ were specifically elevated in the sera of hamsters with CCA compared with other groups and progressively increased with the clinical stage. At the cut-off point of 0.4850 on the receiver operating characteristic curve, anti-$HSP90{\alpha}$ could discriminate CCA from healthy control groups with a sensitivity of 76.2%, specificity of 71.4% and total accuracy 75.5%. In the present study, we have shown that anti-$HSP90{\alpha}$ may be a potential useful serum biomarker to discriminate CCA cases from healthy persons.
Altered Expression of Oxidative Metabolism Related Genes in Cholangiocarcinomas
Aukkanimart, Ratchadawan,Boonmars, Thidarut,Juasook, Amornrat,Sriraj, Pranee,Boonjaraspinyo, Sirintip,Wu, Zhiliang,Laummuanwai, Porntip,Pairojkul, Chawalit,Khuntikeo, Narong,Rattanasuwan, Panaratana Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14
Cholangiocarcinoma (CCA) is a rare but highly fatal cancer for which the molecular mechanisms and diagnostic markers are obscure. We therefore investigated the kinetic expression of isocitrate dehydrogenase-1 (IDH1), isocitrate dehydrogenase-2 (IDH2) and homogentisate 1,2-dioxygenase (HGD) during the tumorigenesis of O. viverrini infection-associated CCA in an animal model, and confirmed down-regulation of expression in human cases of opisthorchiasis-associated CCA through real time PCR. Kinetic expression of HGD, IDH1 and IDH2 in the animal model of O. viverrini infection-induced CCA was correlated with human CCA cases. In the animal model, expression of HGD was decreased at all time points (p<0.01) and expression of both IDH1 and IDH2 was decreased in the CCA group. In human cases, expression of HGD, IDH1 and IDH2 was decreased more than 2 fold in 55 cases (70.5%), 25 cases (32.1%) and 24 cases (30.8%) respectively. The present study suggests that reduction of HGD, IDH1 and IDH2 may be involve in cholangiocarcinoma genesis and may be useful for molecular diagnosis.
A Cross-Sectional Study on Intestinal Parasitic Infections in Rural Communities, Northeast Thailand
Sirintip Boonjaraspinyo,Thidarut Boonmars,Butsara Kaewsamut,Nuttapon Ekobol,Porntip Laummaunwai,Ratchadawan Aukkanimart,Nadchanan Wonkchalee,Amornrat Juasook,Pranee Sriraj 대한기생충학열대의학회 2013 The Korean Journal of Parasitology Vol.51 No.6