尹草窓의 生涯와 草窓訣에 關한 硏究

金準泰,尹暢烈 대한한의학원전학회 1992 대한한의학원전학회지 Vol.6 No.-

I have studied life of Yoon-Dong-Li(尹東里), who applied Un-Ki(運氣) theory to medicine during Suk-Jong(肅宗) to Jeong-Jo(正祖) in Yi-Dynasty and also studied his existing writings named 《Cho-Chang-kyeol》(草窓訣). The referenced original work prints were based on 1980's pring of Chung-Ku oriental medical society and National Central Library and The academy a korean studies possessed print. Studied with these books, I have concluded as follows. 1. Yoon-Dong-Li(尹東里) courtesy name is Ja-Mi(子美), pen name is Cho-Chang(草窓). He was born in 1705, Suk-Jong(肅宗) 31yrs, and died in 1784, Jeong-Jo(正祖) 3yrs in Yi-Dynasty. He had lineage of third-generationed-doctor and learned medicine from his uncle, Yoon-Woo-Kyo(尹雨敎). His father Yoon-Yi-Kyo(윤이교) gaved him second influence. 2. Confucianal physician in Ming Dynasty You-Bu(劉溥) respected Ju-Ryeom-Kyo(周濂溪), confucianist in Song-Dynasty and You-Bu(劉溥) does not removed grass in front of window (because in chinese, Cho-Chang(草窓) means grass in front of windows), and named himself Cho-Chang(草窓). Yoon-Dong-Li(尹東里) followed this suit so called himself Cho-Chang(草窓). 3. The main contents of 《Cho-Chang-Kyeol》(草窓訣), <Un-Ki-Yeon-Lon>(運氣衍論) was written in 1725, when Yoon-Dong-Li(尹東里) was 21yrs old and printed in 1736. The other part of 《Cho-Chang-Kyeol》(草窓訣), <Yong-Yak-Pyeon>(用藥篇) was written in 1746. These two parts were not written in the same time. The <Un-Ki-Yeon-Lon>(運氣衍論) was written 11years earlier than <Yong-Yak>(用藥). Two parts were combined another day and named 《Cho-Chang-Kyeol》(草窓訣). 4. Existing 《Cho-Chang-Kyeol》(草窓訣) is transcribed printing with the content of "Five elements motion and the six kind of natural factors theory"(五運六氣論). Each edition is generally similar in content, but also has different points each other so naw we hardly finds a complete set of works. 5. 《Cho-Chang-Kyeol》(草窓訣) is a first technical book which treats of Un-Ki(運氣) theory in korea. 6. The contents of <Un-Ki-Yeon-Lon>(運氣衍論) of 《Cho-Chang-Kyeol》(草窓訣) is mechanism of diease according to excess and insuffciency of five elements motion and six kinds of natural factors, and symptoms and priscriptions, includes variated priscriptions. 7. Two parts in <Un-Ki-Yeon-Lon>(運氣衍論) of 《Cho-Chang-Kyeol》(草窓訣), 'Sang-tong'(相通) and 'Kak-Tong'(各通), threats of mechanisim of the disease according to five elements, with the principle of inter-promoting and inter-acting, in the change of ten heavenly stems and five elements motion. 8. In the <Yong-Yak-Pyeon>(用藥篇) of 《Cho-Chang-Kyeol》(草窓訣) describes priscription for clinical application according to Un-Ki(運氣) and also records about misuse of medicine. 9. In the 《Cho-Chang-Kyeol》(草窓訣), most of priscription are common using one, which also found in 《Dong-Ui-Bo-Gam》(東醫寶鑑) and there are few of priscriptions by Yoon-Dong-Li(尹東里).

Apoptosis and necroptosis‑inducing effects of arctigenin on nasal septum carcinoma RPMI‑2650 cells in 2D and 3D culture

Yoon‑Jin Lee,Kwan‑Sik Park,Byoung Joon Baek,Kyong‑Ae Lee,Sang‑Han Lee 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

Backgrounds Arctigenin derived from the seeds of Arctium lappa Linnaeus is known as an anticancer drug candidate by targeting various pathways involved in anticancer therapy. Methods Using 2D monolayer and 3D spheroid culture systems in nasal septum carcinoma RPMI-2650 cells, the effects of arctigenin and dexamethasone on cell viability, ROS levels, ATP level, mitochondrial function, apoptosis and necroptosis were examined. Results The combination treatment of both compounds induced strong cytotoxicity, accompanied by increases of sub-G0/ G1 peak, annexin V-PE-positive cells, and ROS levels, loss of mitochondrial membrane potential, and decrease of cellular ATP content. These changes were observed as simultaneous induction of DNA damage, apoptosis, and necroptosis. A series of changes by arctigenin and dexamethasone were efficiently restored by decreasing ROS levels or supplementing ATP. Treatment of 3D spheroids with arctigenin and dexamethasone decreased cell viability in the spheroids, but it was slightly resistant than cells under 2D conditions. In addition, this phenomenon was accompanied by an increase in mediators for both apoptosis and necroptosis. Conclusion Results of this study suggest that the apoptosis and necroptosis-inducing effects of arctigenin are associated with ATP depletion due to oxidative mitochondrial dysfunction.

표면 거칠기가 난류 유동장에 미치는 효과에 대한 실험적 연구

윤준용 漢陽大學校 工學技術硏究所 1998 工學技術論文集 Vol.7 No.1

유동장의 속도나 난류 분포를 변화시키는 표면 거칠기 효과는 공학적으로 중요한 연구대상중의 하나이다. 현재까지 거칠기가 존재하는 표면위에서의 난류 유동장에 관한 연구자료는 많지 않으며, 그간의 연구자료는 거칠기 요소를 단순화시키거나 일정한 조건의 거칠기에 대해서만 다루었다. Patel, Yoon(1996)등이 거칠기 효과를 충분히 고려할수 있는 난류 모델을 개발하는등 수치 해석에서도 거칠기에 대한 응용이 이루어지고 있지만, 다양한 거칠기 효과를 연구한 자료는 미미하다. 이에 보다 다양한 거칠기 조건과 유동 조건에 기초한 유동장을 실험적으로 해석였다. 원하는 유동장을 생성시키고 다양한 거칠기 조건의 변화를 위해 직사각단면의 덕트에서 실험하였으며, 2차원 유동장의 난류 특성을 파악하기 위해 열선 유속계를 사용하였다. The effect of surface roughness that changes velocity profile or turbulent distribution of flow field is among the important engineering research area. Until now, there are few research works done on turbulent flows over rough surfaces. A little works dealt with simplified or constantly conditioned roughness elements. Even though study of roughness in the numerical analysis like that Patel and Yoon(1996) had developed about the turbulent model applicable to the roughness effect, only few studies of various roughness effect exist. So, the experimental analysis of the flows in more realistic and plausible conditions based on more various roughness types and flow conditions has done. To acquire the good flow conditions and to change the roughness conditions, duct with rectangular cross section was used as experimental apparatus, and hot-wire anemometer was used for the measurements of 2-dimensional turbulent characteristics.

알레르기 환자에서 MAST-CLA 검사의 의의

남해선,황규윤,,백병준,정윤영,오천환,조성란,박준수 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

To evaluate usefulness of application of MAST-CLA to indetify allergens, authors conducted MAST-CLA allergen-specific IgE assay and collected allergy related symptoms in 118 allergic patients diagnosed at Soonchunhyang University Chunan Hospital during October 1998 through January 2000. The results were as followings; 1. The mean (SD) age was 23.1 (±12.17) years old and teenagers accounted for 33.1% of patients. 2. The frequent allergic symptoms were sneezing (59.3%), rhinorrhea (53.4%), nasal stiffness (44.1%), itching sensation (24.6%), cough or sputum (16.1%), and eye symptom (8.5%) in order. 3. Among these subjects, 62.7% of patients revealed at least more than one specific allergen and 70.3% showed elevated total IgE levels by MAST-CLA. The three most frequent specific allergens were Dermatophagoides farinae (47.5%), Dermatophagoides pteronyssinus (45.8%), and house dust (30.5%). 4. While age was not significantly related to positive of both specific allergens and total IgE (P>0.05), sneezing and nasal stiffness were significantly associated with positive of specific allergen and total IgE, respectively (both P<0.05). 5. Total IgE increased with the number of specific allergens, but both specific allergen and total IgE were not significantly related to increases of allergic symptoms (P>0.05). In conclusion, our data suggest that MAST-CLA allergen-specific IgE assay is useful measure for identification of causative allergens in allergic patients, however, it is recommended that more specific allergic antigens should be determined and replaced or added to Korean inhalent panel of MAST-CLA.

FEM에 의한 Al07075/CFRP 적층재의 탄성계수 해석

윤한기,안광주,김연겸,박준수 東義大學校産業技術開發硏究所 1998 産業技術硏究誌 Vol.12 No.-

As for the properties on both the aluminum and the CFRP which are used to make A17075/CERP multi-layered hybrid composites, CRALL(carbon reinforced aluminum laminate). For CRALL specimen, FEM analysis is compared with experimental results. It is shown that the rule of mixture is well agreed with experiment result in A/C 0001 layered 1 ply. However, differences are conceivable in A/C 0003 and A/C and A/C 0005 because of the effect of fiber volume fraction. In the A/C 0001 specimen case, the elastic modulus of the unnotched and circular notched CRALL specimen by FEM analysis are agreed with the experimental results, but that of A/C 0003 and A/C 0005 specimens had high CFRP volume fraction doesn't agree with experimental results.

참깨에서 추출한 Sesamin 섭취가 혈청 지질 농도에 미치는 영향

윤명호,신준한,김한수,탁승제,최병일 아주대학교 1997 아주의학 Vol.2 No.2

Objectives : High serum cholesterol is one of the major risk factors of coronary artery disease. We investigated the lipid-towering property and the side effects of sesamin, an unsaturated fatty add extracted from sesame oil, for the primary prevention of coronary artery disease. Methods : The 37 patients (20 mates and 17 females) with hyperlipidemia, ages ranging from 22 years to 70 years old (48±12), who did not have atherosderotic diseases except essential hypertension were given three capsules of sesamin once daily for 6 weeks. The lipid profile of the patients were examined before and after sesamin treatment, and the patients were grouped according to the presence or abscence of hypertension, smoking habit and obesity. Result : Compared with pretreatment, the total cholesterol level of sesamin treated group decreased significantly (254.2±29.6 versus 241.6 34.0 ㎎/dl, p< 0.05). The level of LDL-cholesterol (162.6±24.3 versus 156.6±32.8 ㎎/dl)HDL- cholesterol (47.5±10.0 versus 47.0±8.7 ㎎/dl) and triglyceride (196.5±95.4 versus 179.3±96.7 ㎎/dl) and the ratio of LDL/HDL- cholesterol (3.6±0.9 versus 3.4±0.9) were not significantly different. The effect of cholesterol lowering property of sesamin was predominant in hypertensive, non- smoking and obese group (P< 0.05 vs pretreatment). The laboratory tests including complete blood cell counts, serum transaminases, total protein, albumin, blood urea nitrogen, creatinine and blood glucose did not change significantly. Conclusion : The lipid lowering effect of sesamin was statistically significant on the total cholesterol particularly with obese, non-smoking and hypertensive patients. There was no significant side effect during sesamin administration. Therefore, three capsules of sesamin as a single daily dose were effective in lowering total cholesterol and safe to administer in patients with hyperlipidemia.

Photoacoustic Spectroscopy에 의한 화합물 반도체의 물성연구

윤화중,금채,양준묵 충남대학교 기초과학연구소 1984 연구논문집 Vol.5 No.-

When chopped light inpinges on some condenced matters such as HgS, HgI_2 and GaSe semiconductors, in an enclosed cell, the acoustic signals are produced within the cell. These acoustic signals were detected by using a gas-phase microphone in order to investigate the physical propesties of the samples. In order to carry out investigation, PA-cell was first disigned and made so as to produce higher sensitivity to acoustic signals. Second, an analysis of the photoacoustic spectrum of the various compounds was carried out to obtain the intensity of the PA-signal in terms of light wave-length and to calculate the energy band gaps occurring according to energy transition. The agreement between the results obtained by this conventional PAS technique and the results obtained by the optical spectrum method was good. In additional analysis conducted on the basis of the R-G theory and the Sze theory are capable of determining the characteristics of energy transition of semiconductors.

소결법을 이용한 Si_3N_4, ZrO_2(PSZ)/SUS계 경사기능재료의 제조에 관한 연구

尹正模,朴豊玉,奇俊舒 全北大學校 1996 論文集 Vol.42 No.-

Generally, main problem of heterogeneous materials, composed with metal/ceramics, is wide difference of thermal expansion that exists in layers between metal and ceramics. So new materials are developing, so called FGM(Functionally Gradient Materials), that has relaxation of thermal stress and thermal barrier effect.

흰쥐에서 방광경부 부분폐쇄의 제거가 방광근의 수축력에 미치는 영향

김준철,윤재영,황태곤,박용현,김광명 大韓泌尿器科學會 1997 Korean Journal of Urology Vol.38 No.12

住民運動參與의 決定要因에 관한 硏究

尹晙相,申尹澈 公州大學校 産業開發硏究所 1993 産業開發硏究 Vol.1 No.-

The objectives of the study were 1) to determine related variables of people's participation in collective action against three public community development administration projects, 2) to draw implications for development of democratic community development administration. To collect data, three areas in South Chung-Chong Province where such collective action took place were selected and a total of 261 residents were sampled as final subjects of survey. The degree of people's participation as dependent variable was measured mainly by Likert style ranging from 6-30 points on average. The independent variables were divided into two : individual attributes(sex, age, schooling, job, income, perceived level of living, period of living) and attitude valuables(community satisfaction, community cohesiveness, community leadership, political efficacy, political reliability, interest in community development project, benefit in community development project, wills of participation in community development project) Interview and/or questionnaire method was the main method of data collection. The statistics to determine related variables used in this study were analysis of variance and multiple regression analysis with a .01 significance level. The major findings of this study were as follows; 1. Five personal characteristics out of 5 associated with the degree of people's participation in collective action by analysis of variance were selected: sex, age, schooling, income, perceived level of living. 2. As a result of multiple regression analysis, seven variables of affecting people's participation in collective action, were determined: (1) interest in community development project, (2) income, (3) sex (4) age (5) community leadership, (6) benefit in community development project (7) political efficacy. Out of those seven variables the interest in community development project had the highest influence on the people's participation in collective action(10.9%). 3. Therefore, four implication were drawn for more efficient democratic community development administration: (1) planning of community development projects from below, (2) widening people's participation in community development administration, (3) openness information system from community development administration, (4) acclimatization of social movement through adult/continuing education.