Use of Topical Rapamycin as Maintenance Treatment after a Single Session of Fractionated CO₂ Laser Ablation: A Method to Enhance Percutaneous Drug Delivery

( Jongwook Oh ),( Jihee Kim ),( Won Jai Lee ),( Ju Hee Lee ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.5

Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disorder with an incidence of approximately 1 in 5,000 to 10,000 live births. TSC has various clinical manifestations such as multiple hamartomas in systemic organs, including the skin. Angiofibromas are the most common skin lesions in patients with TSC. Although benign, angiofibromas develop in childhood and puberty, and can be psychosocially disfiguring for patients. Skin lesions in TSC, specifically angiofibromas, have no significant risk of malignant transformation after puberty; thus, they require no treatment if not prominent. However, the presentation of TSC is important owing to its impact on patient cosmesis. Surgical treatment and laser therapy are the mainstream treatments for angiofibromas. Although the evidence is limited, topical mammalian target of rapamycin inhibitors such as sirolimus (rapamycin) are effective in facial angiofibroma treatment. We describe an adult patient with an angiofibroma who had an excellent response to treatment with topical rapamycin after a single session of carbon dioxide (CO₂) laser ablation. The patient showed no sign of relapse or recurring lesions for a year. CO₂ laser ablation may serve as a new paradigm of treatment for angiofibromas in TSC. Since the selection of laser devices can be limited for some institutions, we suggest a rather basic but highly effective approach for angiofibroma treatment that can be generally applied with the classic CO₂ device. (Ann Dermatol 31(5) 555∼558, 2019)

New Approach Way Using Substituent Group at Core Chromophore for Solution Process Blue Emitter.

Lee, Sunmi,Kim, Seungho,Lee, Jaehyun,Kim, Beomjin,Park, Jongwook American Scientific Publishers 2015 Journal of Nanoscience and Nanotechnology Vol.15 No.2

<P>Comparing the conventional vapor desposition process for OLEDs, the solution process using small molecules has merits of low production cost because of many reasons. For the solution process blue flourescent material, tertiary butyl (T) and anthracene (A) were first introduced as substituents to TAT core part, 2-tert-butyl-9,10-bis(3',5'-diphenylbiphenyl-4'-yl)anthracene (T-TAT) and 2-(9-anthracenyl)-9,10-bis(3',5'-diphenylbiphenyl-4'-yl)anthracene (A-TAT). All three materials indicated typical absorption band of anthracene in the range of 350 to 400 nm. T-TAT exhibited similar optical properties to TAT, but A-TAT has longer absorption and PL emission compared to other two compounds. In case of spin-coated film, A-TAT exhibited absorption maximum value of 408 nm and photoluminescence maximum value of 469 nm. T-TAT and A-TAT can be applicable to solution process as a blue fluorescence material.</P>

Ontology-based Recommendation System for Maintenance of Korean Architectural Heritage

Jongwook Lee(이종욱) 한국컴퓨터정보학회 2019 韓國컴퓨터情報學會論文誌 Vol.24 No.10

본 논문에서는 한국 건축 유산 유지 보수를 지원하기 위한 온톨로지 기반의 추천 시스템을 제안한다. 본 연구는 다음을 포함한다: 1) 건축 유산의 수리 정보를 표현하는 온톨로지 디자인, 2) 수리 사례 DB 구축, 3) 수리 방법 추천 시스템 개발. 본 연구에서는 기존 문화유산 온톨로지를 참조하여 한국 목조 건축문화유산의 정보를 표현하는 온톨로지를 디자인 하였다. 둘째, 국립 문화재 연구소와 문화재청에서 제공하는 수리 내용 및 전문가 인터뷰 데이터를 바탕으로 수리 정보 데이터베이스를 구축하였다. 셋째, 우리는 가장 유사한 현상과 원인을 가진 한국 목조 건축문화유산의 수리 방법을 추천하는 시스템을 개발하였다. 이 연구는 수리 지식을 공유하고 건축문화유산 수리를 위한 방법을 결정하는데 기여한다. In this paper, we propose ontology-based recommendation system for supporting maintenance of Korean architectural heritage. This study includes the following: 1) design of ontology expressing repair information of architectural heritage, 2) creation of repair case DB, 3) creation of a recommendation system of repair method. For this study, we designed the ontology that expresses the information of Korean wooden building cultural heritage by referring to the existing heritage ontologies. Second, we created the repair information database based on the repair contents and the expert interview data provided by the National Institute of Cultural Heritage and the Cultural Heritage Administration. Third, we developed a system that recommends the repair method of Korean wooden architectural heritage with the most similar phenomena and causes. This study contributes to sharing repair knowledge and determining repair methods for architectural heritage repair.

A Study for the Process of Creating Korean Journal Citation Reports (KJCR)

Jongwook Lee,Byung-Kyu Kim,,Beom-Jong You,Mu-Yeong Kang 한국콘텐츠학회 2011 ICCC International Digital Design Invitation Exhib Vol.2011 No.12

Combination treatment with microneedle radiofrequency and ablative fractional laser in acne and postacne scars

( Jongwook Oh ),( Jihee Kim ),( Young In Lee ),( Ju Hee Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Treatment of Acne scars remains a therapeutic challenge with broad range of treatment options. Especially for the atrophic scars, ablative fractional laser has demonstrated its efficacy in various reports. Meanwhile, microneedle radiofrequency (RF) can allow a more selective microthermal zone of the dermis without epidermal damage. Objectives: The aim of this study was to analyze the effect and safety of combination treatment with AFL and microneedle RF in acnes and postacne scars. Methods: The photographs of 50 patients with acnes and post-acne scars who received microneedle RF treatments were retrospectively reviewed. The reduction in numbers of active acne lesions and postacne scars, overall improvement degrees were evaluated by two dependent dermatologists, and patients’ satisfaction levels were evaluated from the patients. Results: The active acne lesions, global improvement scale and patient satisfaction levels showed significant improvement in all treated patients, although there was no significant difference in these parameters between RF alone group and combination treatment group. However, the reductions of box scars and rolling scars showed significant improvement in the combination therapy group compared to the RF alone group. Conclusion: The combination treatment with AFL and microneedle RF therapy is effective in treatment of inflammatory acne lesions and postacne scars.

Supercapacitive properties of composite electrodes consisting of activated carbon and 1,4-dihydroxynaphthalene derivatives

Lee, Hae Soo,Latifatu, Mohammed,Kim, Beom-Cheol,Park, Jeong Ho,Lee, Young-Gi,Kim, Kwang Man,Park, Jongwook,Baek, Yong Gu,Ko, Jang Myoun Elsevier 2016 Synthetic metals Vol.217 No.-

<P><B>Abstract</B></P> <P>Two 1,4-dihydoxynaphthalene (PhQH<SUB>2</SUB>)-based derivatives (coded as HBU-551 and HBU-552) are synthesized by reacting with different amines (i.e., tryptamine and phenethylamine, respectively) to use as organic additives of activated carbon supercapacitors. The composite electrodes with HBU-551 and HBU-552 are also prepared by blending with the ratio of 70:25w/w, and their supercapacitive properties are investigated in terms of redox behaviors and specific capacitance evolutions against scan rate and cycle life. The organic additives and their composites with activated carbon are dominantly characterized by PhQ-PhQH<SUB>2</SUB> redox transition accompanying a two-electron two-proton process, and weakly affected by reversible redox reaction of nitrogen in the NH group, which involves an additional one-electron one-proton process. Thus, the composite electrodes show higher specific capacitance over 210Fg<SUP>−1</SUP> due to the synergistic effect between activated carbon (pseudocapacitance) and organic additives (redox behavior). Cycle performance and high-rate capability can also be enhanced by the adoption of PhQH<SUB>2</SUB>-based organic additives for their pore-filling morphology to increase the packing density of composite electrodes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Two 1,4-dihydoxynaphthalene-based derivatives are newly synthesized. </LI> <LI> Their composite electrodes with activated carbon achieved specific capacitance of 210Fg<SUP>−1</SUP>. </LI> <LI> Synergistic effect between pseudocapacitance and the redox behavior of organic additives was shown. </LI> </UL> </P>

Enforced Effects of Side Group Substitution Position on Luminescence Properties; Synthesis of Bis(dipyrrinato)zinc Complex Derivatives

Lee, Sola,Seok, Chang-Hun,Park, Youngil,Lee, Areum,Jung, Dong Hyun,Choi, Seung-Hoon,Park, Jongwook Informa UK (TaylorFrancis) 2010 Molecular Crystals and Liquid Crystals Vol.531 No.1

Analysis and Suggestions of Digital Heritage Policy

Jongwook Lee(이종욱) 한국컴퓨터정보학회 2019 韓國컴퓨터情報學會論文誌 Vol.24 No.10

본 논문은 국내외 디지털 문화 활성화 정책을 4가지 유형으로 나누었다. 또한 각 정책의 대표적인 프로젝트를 설명하고 한계를 분석하였다. 마지막으로 이러한 한계점들을 극복 할 수 있는 솔루션을 제안하였다. 최근 5G 네트워크 기술, 증강현실 및 가상현실 기술의 발달로 인한 일상생활의 변화는 문화유산의 보존 및 활용 방식에 많은 변화를 가져 왔다. 특히, 디지털 기술은 문화유산의 디지털화, 디지털 데이터의 저장 및 관리, 문화유산의 디지털 복원, 시공간 및 다감각 체험을 가능하게 하였다. 이 연구는 국내 및 국제 디지털 유산 정책을 디지털 인프라 구축, 공유 및 커뮤니케이션 플랫폼 구축, 홍보 및 시범 콘텐츠 제작 지원 정책으로 나누었다. 이 연구는 디지털 유산 정책을 분류하고 디지털 유산 정책 동향 설명하고 개선점을 제안하는데 기여한다. In this paper, we divided domestic and foreign digital cultural activation policies into four types. We also described projects of each policy and analyzed the limitations of the policy. Finally, we suggested solutions to overcome these limitations. Changes in daily life caused by the recent development of 5G network technology, augmented reality, and virtual reality technology have brought many changes in the way of preservation and utilization of cultural heritage. In particular, digital technology is used for digitization of cultural heritage, storing, and managing digital data, digitally restoring cultural heritage, and enabling time, space, multi-sensory experiences. For this purpose, new policies was required to utilize this. This study divides domestic and international digital heritage policies into digital infrastructure construction, sharing and communication platform construction, public relations, and demonstration contents production support policies. This study is meaningful in classifying the fields of digital heritage policy and introducing digital heritage policy trends. It is also meaningful to suggest ways to improve digital heritage policies through analysis of domestic and foreign cases.

Oleanolic Acids Inhibit Vascular Endothelial Growth Factor Receptor 2 Signaling in Endothelial Cells: Implication for Anti-Angiogenic Therapy

Lee, Da-Hye,Lee, Jungsul,Jeon, Jongwook,Kim, Kyung-Jin,Yun, Jang-Hyuk,Jeong, Han-Seok,Lee, Eun Hui,Koh, Young Jun,Cho, Chung-Hyun Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.8

Angiogenesis must be precisely controlled because uncontrolled angiogenesis is involved in aggravation of disease symptoms. Vascular endothelial growth factor (VEGF)/VEGF receptor 2 (VEGFR-2) signaling is a key pathway leading to angiogenic responses in vascular endothelial cells (ECs). Therefore, targeting VEGF/VEGFR-2 signaling may be effective at modulating angiogenesis to alleviate various disease symptoms. Oleanolic acid was verified as a VEGFR-2 binding chemical from anticancer herbs with similar binding affinity as a reference drug in the Protein Data Bank (PDB) entry 3CJG of model A coordination. Oleanolic acid effectively inhibited VEGF-induced VEGFR-2 activation and angiogenesis in HUVECs without cytotoxicity. We also verified that oleanolic acid inhibits in vivo angiogenesis during the development and the course of the retinopathy of prematurity (ROP) model in the mouse retina. Taken together, our results suggest a potential therapeutic benefit of oleanolic acid for inhibiting angiogenesis in proangiogenic diseases, including retinopathy.

OST-3964, A Human Cathepsin K Inhibitor, Inhibits Bone Resorption In Vitro

Lee JongWook,Bae EunJu,Kim MiKyung,Kim HaDong,Sson MoonHo,Kim SoonHoe,Kim WonBae,Hur Youn,Lee ChunHo,Lee BongYong 大韓藥學會 2002 大韓藥學會 總會 및 學術大會 Vol.2002 No.1