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RISS 인기검색어
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- 저자 : Jirun, Peng (검색결과 4 건)
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Jirun, Peng,Zhang, Guoxin,Kim, Hyun Kee,Ha, Seon-Ah,Zhongtian, Jin,Shishi, Qiao,Zhuqingqing, Cui,Lei, Gong,Yoo, Jinah,Kim, Sanghee,Park, Yong Gyu,Wang, Jing,Yang, Yang,Xu, Zekuan,Huang, Zuhu,Lee, Yun IOS Press 2011 Disease markers Vol.30 No.6
<P>Serum alpha fetoprotein (AFP) is the most widely used tumor marker in detecting patients with hepatocellular carcinoma (HCC). However, it has been indicated that HCCR-1 (human cervical cancer oncogene 1) might be supplementary to AFP in the detection. We conducted a prospective study in 120 normal and 524 liver disease patients to evaluate the significance of simultaneous measurement of 2 tumor markers (AFP and HCCR-1) in the diagnosis of HCC through the cohort study in Korea and China. We also performed immunohistochemical studies using 25 normal subjects (N), 32 liver cirrhosis (LC) and 116 HCC tissues. The sensitivities of AFP (20 ng/mL) and HCCR-1 (10 ng/mL) in HCC were 55.8% (164/294) and 44.2% (130/294), respectively. When AFP was combined with HCCR-1, sensitivities increased to 4.2% (N), 12.7% (chronic hepatitis; CH), 50.0% (LC), and 77.2% (HCC), respectively. Although there was no significant difference in the diagnostic rate for HCC between AFP and HCCR-1, many cases for AFP-negative HCC were positive for HCCR-1 and vice versa. Moreover, the combined use of AFP and HCCR-1 improved the diagnostic rate to 70.8% in small HCC (< 2 cm) and 81.6% in large HCC (≥ 2 cm), respectively. AFP and HCCR-1 are independent markers. Our result suggests that the HCCR-1 could be an useful biomarker for HCC while the diagnostic rate could be significantly improved in the combined use of HCCR-1 and AFP.</P>
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A new description of the fractal dimension of particle aggregates in liquid medium
Xing, Jun,Ding, Shiqiang,Liu, Zhengning,Xu, Jirun Korean Association for Particle and Aerosol Resear 2015 Particle and Aerosol Research Vol.11 No.4
The possible existence forms of particle aggregates in liquid medium are classified into four different types according to their morphological characteristics, including the single particles that are separated from each other, the linear aggregates in which all component particles are located in a line, the planar aggregates where all particles are arranged on a plane, and the volumetric aggregates where all particles forms a three-dimensional space. These particle aggregates with different space morphologies have different fractal dimensions and different influence on the rheological phenomena of the solid-liquid system. The effects of various aggregates on the suspension viscosity are analyzed and related with the particle concentration, and then a mathematical model is presented to determine the fractal dimensions of various aggregates by measuring the apparent viscosity of the solid-liquid system. In the model, the viscous fractal dimension is developed as a new concept, the fractal dimensions of different aggregates can be obtained separately and then the relative components of various aggregates experimentally analyzed.
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Thakoon Thitiset,Siriporn Damrongsakkul,Supansa Yodmuang,Wilairat Leeanansaksiri,Jirun Apinun,Sittisak Honsawek 한국생체재료학회 2021 생체재료학회지 Vol.25 No.3
Background: A novel biodegradable scaffold including gelatin (G), chitooligosaccharide (COS), and demineralized bone matrix (DBM) could play a significant part in bone tissue engineering. The present study aimed to investigate the biological characteristics of composite scaffolds in combination of G, COS, and DBM for in vitro cell culture and in vivo animal bioassays. Methods: Three-dimensional scaffolds from the mixture of G, COS, and DBM were fabricated into 3 groups, namely, G, GC, and GCD using a lyophilization technique. The scaffolds were cultured with mesenchymal stem cells (MSCs) for 4 weeks to determine biological responses such as cell attachment and cell proliferation, alkaline phosphatase (ALP) activity, calcium deposition, cell morphology, and cell surface elemental composition. For the in vivo bioassay, G, GC, and GCD, acellular scaffolds were implanted subcutaneously in 8-week-old male Wistar rats for 4 weeks and 8 weeks. The explants were assessed for new bone formation using hematoxylin and eosin (H&E) staining and von Kossa staining. Results: The MSCs could attach and proliferate on all three groups of scaffolds. Interestingly, the ALP activity of MSCs reached the greatest value on day 7 after cultured on the scaffolds, whereas the calcium assay displayed the highest level of calcium in MSCs on day 28. Furthermore, weight percentages of calcium and phosphorus on the surface of MSCs after cultivation on the GCD scaffolds increased when compared to those on other scaffolds. The scanning electron microscopy images showed that MSCs attached and proliferated on the scaffold surface thoroughly over the cultivation time. Mineral crystal aggregation was evident in GC and greatly in GCD scaffolds. H&E staining illustrated that G, GC, and GCD scaffolds displayed osteoid after 4 weeks of implantation and von Kossa staining confirmed the mineralization at 8 weeks in G, GC, and GCD scaffolds.
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Zhang, Guoxin,Ha, Seon-Ah,Kim, Hyun K.,Yoo, Jinah,Kim, Sanghee,Lee, Youn S.,Hur, Soo Y.,Kim, Yong W.,Kim, Tae E.,Park, Yong G.,Wang, Jing,Yang, Yang,Xu, Zekuan,Song, Eun Y.,Huang, Zuhu,Jirun, Peng,Zho IOS Press 2012 Disease markers Vol.32 No.4
<P>Hepatocellular carcinoma (HCC) is one of the most frequent malignant tumors in the world. The only serological marker widely used for the diagnosis of HCC is alpha-fetoprotein (AFP). Despite that AFP is widely used for the diagnosis of HCC, it has a limit as a serological marker due to its low sensitivity and specificity. The human cervical cancer proto-oncogene 1 (HCCR-1) was previously reported as a new biomarker for HCC. To further evaluate the HCCR-1 as a biomarker for HCC, we conducted the prospective cohort study. We evaluated the significance of simultaneous measurement of 2 tumor markers in the diagnosis of HCC in China, Japan and Korea. Two markers for HCC, AFP and HCCR-1, were measured in the sera obtained from 1,338 patients at the time of initial diagnosis of HCC. Of the 1338 HCC patients, 616 (46%) and 686 (51.3%) were sero-positive for AFP and HCCR-1, respectively. The positive rate for HCC was increased up to 74.1% in combined use of AFP and HCCR-1. Many cases (54%) for AFP-negative HCC were positive for HCCR-1 and vice versa. More importantly, the diagnostic rate for small HCC (< 2 cm) was significantly improved in the combined analysis of AFP and HCCR-1 to 56.9% although it was only 40.1% and 23.4% in the single analysis of HCCR-1 and AFP, respectively. Our result suggests that the HCCR-1 could be an useful biomarker for HCC while the diagnostic rate could be significantly improved in the combined use of HCCR-1 and AFP.</P>
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