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RISS 인기검색어
- 검색키워드
- 저자 : Jirapornkul, Chananya (검색결과 3 건)
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Survival Time and Molecular Subtypes of Breast Cancer after Radiotherapy in Thailand
Kongsiang, Apichat,Tangvoraphonkchai, Vorachai,Jirapornkul, Chananya,Promthet, Supannee,Kamsa-ard, Siriporn,Suwanrungruang, Krittika Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Background: Breast cancer is an important cause of death among women. One way of classifying different forms of breast cancer is by molecular features, usually in terms of the four subtypes: luminal A, luminal B, HER2-enriched, and triple negative. Objectives: This study aimed to investigate the association between molecular subtypes and survival among breast cancer patients treated with radiotherapy. Materials and Methods: A retrospective cohort study was conducted. The subjects were 272 breast cancer patients who had received treatment in the radiotherapy unit at Srinagarind Hospital, Thailand, between 1 January, 1999, and 31 May, 2009. The end of the study was 1 June, 2014. Overall survival was defined as the time elapsing between initial registration at the radiotherapy unit and death or the end of the study. Survival curves were estimated by the Kaplan-Meier method, and a multivariate analysis was performed using Cox's proportional hazard regression model. Results: The patient mean age was $47.5{\pm}10.4$ at the time of diagnosis. Of the 272 patients, 146 (53.7%) were classified as luminal A, 12 (4.4%) as luminal B, 30 (11.0%) as HER2-enriched, and 84 (30.9%) as triple negative. The overall survival rates at 1, 3 and 5 years were 87.1%, 68.4% and 59.2%, respectively. According to molecular subtypes, HER2-enriched patients had the lowest 5-year survival rate (30.0 %, 95%CI: 15.02-46.55). The median follow-up time was 8.37 years. In the Cox model analysis a higher risk of death was found for patients with HER2-enriched ($HR_{adj}=3.34$, 95%CI:1.96-5.67), triple negative ($HR_{adj}=2.17$, 95%CI: 1.44-3.27), and stage IIlB ($HR_{adj}=2.20$, 95%CI: 1.16-4.17) cancers. Conclusions: The worst survival rates were among patients classified as HER2-enriched, triple negative and at stage IIIB. Early detection and an advanced treatment modality are needed to help these patients.
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Factors Affecting Cervical Cancer Screening Uptake by Hmong Hilltribe Women in Thailand
Wongwatcharanukul, Laead,Promthet, Supannee,Bradshaw, Peter,Jirapornkul, Chananya,Tungsrithong, Naowarat Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
Background: Cervical cancer is relatively common in Thai women, but the proportion of females receiving Pap smear screening is still low. Objective: The purpose of this cross-sectional study was to study factors related to cervical cancer screening uptake by Hmong hilltribe women in Lomkao District, Phetchabun Province. Materials and Methods: Interview data were collected from 547 of these women aged 30-60 years living in the study area and analyzed using multiple logistic regression. Results: The results showed that 64.9% of the study sample had received screening, and that 47.2% had attended due to a cervical screening campaign. The most common reason given for not receiving screening was lack of time (21.4%). The factors found to be positively associated with uptake (p value <0.05) were as follows: number of years of school attendance (OR=1.56, 95%CI:1.02-2.38), animistic religious beliefs (OR=0.55, 95%CI:0.33-0.91), a previous pregnancy (OR=6.20, 95%CI:1.36-28.35), receipt of information about cervical cancer screening (OR=2.25, 95%CI:1.35-3.76), and perceived risk of developing cervical cancer (OR=1.83, 95%CI:1.25-2.67). Conclusions: To promote the uptake of cervical screening, Hmong hilltribe women need to know more about cervical cancer and cervical cancer screening, and access to screening services should be provided in conjunction with existing everyday services, such as family planning and routine blood pressure monitoring or diabetes services.
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Proximity of Health Care Center and Cervical Cancer Screening Uptake in Thailand
Polrit, Kornnika,Kamsa-ard, Siriporn,Jirapornkul, Chananya,Promthet, Supannee Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.7
Background: Cervical cancer is one of the most common cancers among women worldwide, and in Thailand is the second most common cancer among women. In 2008, a national cervical cancer screening programme was implemented in Thailand, but coverage remains relatively low. Objectives: The purpose of the study was to investigate whether cervical cancer screening uptake is associated with the area of residency in Thailand. Materials and Methods: A case-control study was carried out in women aged 30 to 60 year-old, who live in Sikhiu district, Nakhon Ratchasima province, Thailand. Structured-questionnaires were used to interview 226 women (cases) who had attended cervical cancer screening in the last five years and 226 women (controls) who had not. Multiple logistic regression was used to investigate the association between the area of residency and cervical cancer screening uptake. Results: After controlling for parity, marital status and duration of hormonal contraceptive use, an association between the area of residence and cervical cancer screening uptake could not demonstrated ($OR_{adj}$ 1.27, 95%CI: 0.79, 2.04). Conclusions: We found no evidence to suggest remoteness to health care center led to lower cervical cancer screening uptake.
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