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Han, Kil-Woo,Chun, Ju Lan,Lee, Ji Hey,Kim, Keun-Jung,Lee, Kyung-Bon,Gotoh, Taksfumi,DO, Chang Hee,Kim, Min Kyu FACULTY OF AGRIC PUBLICATIONS-KYUSHU UNIV 2015 Journal of the Faculty of Agriculture, Kyushu Univ Vol. No.
<P>To improve early embryonic development, many strategies have been studied in various species including bovine. The co-culture of embryos with somatic cells has been known to improve embryo quality during in vitro culture and pregnancy rates compared with conventional culture systems. The co-culture of embryos with oviductal cells which have been used for blastocyst expansion appears to shorten the time needed for synthesis of hCG, early embryo development, and hatching blastocysts. The aim of this study is to investigate whether the co-culture system with amniotic membrane stem cells (bAMS) improves bovine embryonic development competence. In order to investigate the influence of bAMS on early embryo development, bAMS originated from fetal bovine amniotic membranes were used as the feeder layer during in vitro maturation. The rates of matured oocytes, cleavage division, and blastocysts formation were increased (p<0.05) after co-culture with the bAMS compared to the control group. Moreover the rates of oocyte maturation and embryo development were significantly higher with using bAMS below 5 passages. In addition, the GSH level and the total cell number of blastocysts were significantly higher in co-culture group than in those of control group. Apoptotic cells were found more in the control group, and the expression of anti apoptosis related genes such as Mcl-1 and Bcl-2 were increased after co-culture with bAMS. In conclusion, the present study demonstrated that co-culture with bAMS cells enhances oocyte maturation and embryo developmental competence by increasing GSH level and expression of anti apoptotic genes with reducing apoptotic cells in bovine embryos. We also found that it is more suitable to use bAMS below 5 passages.</P>
Ji Eun Lim,Hye Min Kim,Ju Hee Kim,Hey-Sung Baek,Man Yong Han 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.8
Background: The association between dyslipidemia and asthma in children remains unclear. Purpose: This study investigated the association between dyslipidemia and cholesterol levels in children. Methods: A systematic literature review was performed to identify studies investigating the association between dyslipidemia and asthma in children. The PubMed database was searched for articles published from January 2000–March 2022. Data from a cohort study using electronic health records from 5 hospitals, converted to the Observational Medical Outcomes Partnership Common Data Model (OMOP-CDM), were used to identify the association between total cholesterol (TC) levels and asthma in children. This cohort study used the Cox proportional hazards model to examine hazard ratio (HR) of asthma after propensity score matching, and included an aggregate meta-analysis of HR. Results: We examined 11 studies reporting an association between dyslipidemia and asthma in children. Most were cross-sectional; however, their results were inconsistent. In OMOP-CDM multicenter analysis, the high TC (>170 mg/dL) group included 29,038 children, while the normal TC (≤170 mg/dL) group included 88,823 children including all hospital datasets. In a meta-analysis of this multicenter cohort, a significant association was found between high TC levels and later development of asthma in children <15 years of age (pooled HR, 1.30; 95% confidence interval, 1.12–1.52). Conclusion: Elevated TC levels in children may be associated with asthma.
발효홍삼이 제2형 당뇨병 환자의 혈당 및 인슐린저항성에 미치는 영향
김혜옥(Hey-Ok Kim),박민정(Min-Jung Park),한지숙(Ji-Sook Han) 한국식품영양과학회 2011 한국식품영양과학회지 Vol.40 No.5
본 연구는 홍삼추출물을 Bifidobacterium longum H-1으로 발효시켜 인삼사포닌을 체내에서 흡수가 잘 되는 형태로 변화시킨 발효홍삼을 제2형 당뇨병환자에게 아침과 저녁 식전에 한 캡슐씩 하루 780 ㎎을 섭취하였다. 위약군은 동량의 cellulose를 실험군과 동일하게 제조한 후 같은 방법으로 섭취하도록 하였다. 연구대상자는 약물이나 식사로만 치료하는 총 38명의 제2형 당뇨병 환자로 발효홍삼군 20명(남자 12, 여자 8), 위약군 18명(남자 11, 여자 7)으로 구성되었으며, 두 군의 일반적 특성 및 생활습관은 유의적인 차이가 없었다. 연구결과 발효홍삼을 섭취한 군에서의 공복혈당은 136.29±16.45 ㎎/dL에서 127.71±17.74 ㎎/dL로 유의하게(p<0.05) 감소하였으며, 당화혈색소 역시 7.36±1.02%에서 6.96±0.93%로 감소하였다. 특히 당화혈색소가 8% 이상인 고당화혈색소군에서 유의적으로(p<0.05) 감소하는 것으로 나타났다. 인슐린 저항성은 대조군에서는 유의적 변화가 없는 반면, 발효홍삼군에서는 섭취 전 3.11±1.13 m㏖/L에서 섭취후 2.23±0.71 m㏖/L로 유의한(p<0.01) 감소를 나타내었다. 혈청지질 변화는 없었으며, LDL-콜레스테롤도 발효홍삼군에서 유의한 변화가 없었다. 간 기능 지표인 AST, ALT, γ-GTP와 신장기능 지표인 BUN, creatinine에서 유의적인 차이를 나타내지 않았으며, 정상범위에 속하여 발효홍삼의 안전성을 확인하였다. 이상의 연구 결과 한국인 제2형 당뇨병 환자에 있어 발효홍삼은 혈당 및 당화혈색소 감소와 인슐린 저항성 개선에 효과적인 것으로 나타났으며, 인체 안전성지표인 간 및 신장 기능도 정상으로 확인되었으므로 당뇨병 환자의 혈당 개선을 통해 합병증지연 또는 예방에 있어 효과를 기대할 수 있을 것으로 사료된다. We performed a randomized placebo-controlled trial to determine whether or not fermented red ginseng supplementation modulates blood glucose and insulin resistance in type 2 diabetic patients. A total of 38 patients were randomized to either a fermented red ginseng group or placebo group. The patients in the experimental or placebo group consumed 780 mg of fermented red ginseng or cellulose supplement per day for 12 weeks, respectively. Lifestyle factors and dietary intakes of the patients were not altered during the 12-weeks period. In the fermented red ginseng group after 12 weeks, the fasting blood glucose levels were significantly decreased (136.29±16.45 ㎎/dL to 127.71±17.74 ㎎/dL) and HbA₁c was also decreased. Especially, high HbA1c (HbA1c≥8%, 8.45±0.56% to 7.82±0.53%) was significantly decreased compared to low HbA1c (HbA1c <8%, 6.71±0.85% to 6.44±0.49%) in the fermented red ginseng group. Serum low-density lipoprotein was slightly decreased in the fermented red ginseng group compared to the placebo group. Homeostasis model assessment-insulin resistance was significantly reduced in the fermented red ginseng group compared to the placebo group. These results suggest that fermented red ginseng supplementation could be helpful to reduce blood glucose by improving insulin resistance in type 2 diabetic patients.
Choi, Ahyoung,Han, Ji-Hey,Kim, Eui-Jin,Cho, Ja Young,Hwang, Sun-I Korean Society of Environmental Biology 2019 환경생물 : 환경생물학회지 Vol.37 No.4
Ostrea denselamellosa and Eriocheir japonica samples were collected from the Seomjin River in 2019 as part of the "Research of Host-Associated Bacteria" research program. Almost 200 bacterial strains were isolated from the O. denselamellosa and E. japonica samples and subsequently identified by 16S rRNA gene sequencing. Among the bacterial isolates, ten strains possessed greater than 98.7% sequence similarity with published bacterial species that had not previously been recorded in Korea. These species were phylogenetically diverse, belonging to three phyla, four classes, seven orders, and eight genera. At the genus and class level, the previously unrecorded species belonged to Pseudoalteromonas, Aliivibrio, Rheinheimera, Leucothrix, and Shewanella of the class Gamma-proteobacteria, Olleya of the class Flavobacteriia, Algoriphagus of the class Cytophagia, and Lactococcus of the class Bacilli. The previously unrecorded species were further characterized by examining their Gram staining, colony and cell morphology, biochemical properties, and phylogenetic positions.
Ahyoung Choi,Ji-Hey Han,Eui-Jin Kim,Ja Young Cho,Sun-I Hwang 한국환경생물학회 2019 환경생물 : 환경생물학회지 Vol.37 No.4
Ostrea denselamellosa and Eriocheir japonica samples were collected from the Seomjin River in 2019 as part of the “Research of Host-Associated Bacteria” research program. Almost 200 bacterial strains were isolated from the O. denselamellosa and E. japonica samples and subsequently identified by 16S rRNA gene sequencing. Among the bacterial isolates, ten strains possessed greater than 98.7% sequence similarity with published bacterial species that had not previously been recorded in Korea. These species were phylogenetically diverse, belonging to three phyla, four classes, seven orders, and eight genera. At the genus and class level, the previously unrecorded species belonged to Pseudoalteromonas, Aliivibrio, Rheinheimera, Leucothrix, and Shewanella of the class Gamma-proteobacteria, Olleya of the class Flavobacteriia, Algoriphagus of the class Cytophagia, and Lactococcus of the class Bacilli. The previously unrecorded species were further characterized by examining their Gram staining, colony and cell morphology, biochemical properties, and phylogenetic positions.
( Young-hoon Kim ),( Young-ji Bae ),( Hyung Soo Kim ),( Hey-jin Cha ),( Jae-suk Yun ),( Ji-soon Shin ),( Won-keun Seong ),( Yong-moon Lee ),( Kyoung-moon Han ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.5
Drug metabolism mostly occurs in the liver. Cytochrome P450 (CYP) is a drug-metabolizing enzyme that is responsible for many important drug metabolism reactions. Recently, the US FDA and EU EMA have suggested that CYP enzyme induction can be measured by both enzymatic activity and mRNA expression. However, these experiments are time-consuming and their interassay variability can lead to misinterpretations of the results. To resolve these problems and establish a more powerful method to measure CYP induction, we determined CYP induction by using luminescent assay. Luminescent CYP assays link CYP enzyme activity to firefly luciferase luminescence technology. In this study, we measured the induction of CYP isozymes (1A2, 2B6, 2C9, and 3A4) in cryopreserved human hepatocytes (HMC424, 478, and 493) using a luminometer. We then examined the potential induction abilities (unknown so far) of mesalazine, a drug for colitis, and mosapride citrate, which is used as an antispasmodic drug. The results showed that mesalazine promotes CYP2B6 and 3A4 activities, while mosapride citrate promotes CYP1A2, 2B6, and 3A4 activities. Luminescent CYP assays offer rapid and safe advantages over LC-MS/MS and qRT-PCR methods. Furthermore, luminescent CYP assays decrease the interference between the optical properties of the test compound and the CYP substrates. Therefore, luminescent CYP assays are less labor intensive, rapid, and can be used as robust tools for high-throughput CYP screening during early drug discovery.