리튬이 도핑된 막을 이용한 실리콘-실리콘 접합

정지원,주병권,최우범,정성재,이남양,최두진,오명환 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1

Silicon-to-silicon anodic bonding was accomplished using lithium doped interlayer. Lithium doped interlayers were deposited on silicon substrates by electron beam evaporation, which has a fast deposition rate compared with sputtering method. Silicon-to-silicon bonding occurs in the range of temperatures from 250℃ to 300℃ with the applied voltages from 70V_(DC) to 100V_(DC). The bonding strength obtained from tensile test was about 5MPa under the condition of 80V_(DC) in 300℃. The surface morphology of lithium doped interlayer was studied with the atomic force microscopy (AFM). Finally, secondary ion mass spectroscopy (SIMS) analysis was carried out in order to investigate the role of the lithium ions in bonding mechanism.

Development of a Genistein-enriched Doenjang Using Corn β-Glucosidase

Jee-Hwan Oh,Joo-Won Suh,Jin-Yong Kim,Inhyung Lee 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.5

Genistein, one of the isoflavones in doenjang, is generally known to prevent various cancers, osteoporosis, climacterium, and menopause symptoms, and has better bioavailability and healthful physiological effects than its glucoside, genistin. In both traditional and commercial doenjangs, genistein content ranged from 370 to 1,510 mg/kg, however, significant amounts of genistin also existed at the level of 190 to 350 mg/kg. After treating with corn β-glucosidase, over 84% of genistin in doenjang was converted to genistein. However, physiochemical characteristics such as pH, viscosity, 2-thiobarbituric acid (TBA) value, and color were not changed significantly after corn β-glucosidase treatments. Therefore, this study shows that the improved doenjang with the increased genistein content can be produced using corn β-glucosidase.

한국인에서 자궁경관임신의 치료에 관한 연구

고지환(Jee Hwan Ko),이종범(Jong Bum Lee),오영균(Young Kun Oh),손성경(Song Kyong Son),서영석(Young Seok Seo),이기환(Ki Hwan Lee),남상륜(Sang Lyun Nam),노흥태(Heung Tae Noh),강길전(Kil Chun Kang) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.8

Objective : The study was designed to find out current state of conservative treatment modalities for cervical pregnancies in korean. Method : 64 cases of cervical pregnancies reported by the joining of The Korean Society of Obstetrics & Gynecology from 1960 to 2000 and the 10 cases at Chungnam National University Hospital were analyzed retrospectively. Results : The average age of the 74 cases was 31.7±6.6 years, and the average gestational age at the time of diagnosis was 8.3±3.4 weeks. The average duration of hospitalization was 8.2±4.8 days. Most (67/74) of the patients had previously experienced delivery or abortion. Out of the 74 cases, 36 had total hysterectomy; 4 cases had curettage; 12 were used only methotrexate; 11 had combined curettage and methotrexate; 10 cases had Foley catheter ballooning after curettage. From the 1960's to the end of 1980's, 33 (84.6%) cases out of 39 were performed hysterectomy. Whereas mainly conservative methods, in particular methotrexate treatment, were performed in the 1990's. Among the conservative modalities, Foley catheter ballooning after curettage had the shortest length of hospitalization with 4.3 days. Conclusion : After comparing the conservative methods for treating cervical pregnancies, it was found that methotrexate treatment was performed the most; however, Foley catheter ballooning after curettage seems to be an excellent treatment option.

Eagle씨 증후군의 치험례

오승환,이상철,윤옥병,지유진,김여갑,류동목 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.3

Eagle's syndrome is the term given to symtomatic elogation of the styloid process or mineralization of the stylohyoid or stylomandibular ligament. Since ossification of stylohyoid ligament at cadeva was fist described by De Manchetics in 1652 and Weinlecher described clinical symptom which produced by elongated styloid process and osteotomy of styloid process in 1872, Clinical symptom which include sensation of a foreign body on the pharynx, dysphagai, dysphonia, referred pain, and mouth opening disturbance was termed by Eagle as Eagle's syndrome. then, case reports of Eagle's syndrome are presented. in these cases, the patient's chief complaints included periauricular radiating pain, mouth opening disturbance, foreign body sensation, dysphagia, tenderness on the neck. Through vairous X-ray examination and palpation of tonsillar fossa, elongted styloid process were confirmed. Under the general anesthesia there were successfully removed out via transoral approach technique, described by Eagle. after resented styloid process, they were freed from the symptoms without further complication. Therefor we reported these cases treated by surgical resection of styloid process with good results.

The new designer drug buphedrone produces rewarding properties via dopamine D1 receptor activation : Buphedrone addiction

Oh, Ji-Hwan,Hwang, Ji-Young,Hong, Sa-Ik,Ma, Shi-Xun,Seo, Jee-Yeon,Lee, Seok-Yong,Kim, Hyoung-Chun,Jang, Choon-Gon Wiley (Blackwell Publishing) 2018 Addiction biology Vol.23 No.1

<P>Substituted cathinones are synthetic analogs of the active components of natural products and are widely abused worldwide. However, the rewarding properties of these agents have not yet been evaluated. In this study, we investigated the abuse potential of buphedrone [2-(methylamino)-1-phenylbutan-1-one, alpha-methylamino-butyrophenone] and its effects on the mesolimbic dopaminergic system in mice using conditioned place preference (CPP) analysis, a self-administration test, a locomotor activity test, a behavioral sensitization test and Western blot analysis. Treatment with buphedrone supported CPP and self-administration, enhanced locomotor activity and produced behavioral sensitization when mice were challenged with methamphetamine. SCH23390, a D1 dopamine antagonist, prevented buphedrone-induced CPP, whereas raclopride, a D2 dopamine antagonist, had no effect. SCH23390 also blocked locomotor activity increase by buphedrone, while raclopride partially attenuated locomotor activation. Western blot analysis revealed that repeated buphedrone treatment increased D1 dopamine receptor expression in the dorsal striatum and nucleus accumbens in mice. Collectively, these findings suggest the abuse potential of buphedrone and demonstrate the involvement of the dopaminergic system in the establishment of its rewarding properties.</P>

Thematic Poster : TP-33 ; Clinical Characteristics and Survival of Korean Idiopathic Pulmonary Arterial Hypertension Patients Based on Vasoreactivity

( Jee Hwan Ahn ),( Byung Ju Kang ),( Sun In Hong ),( Jung Su Lee ),( Jae Seung Lee ),( Yeon Mok Oh ),( Sang Do Lee ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-

Background: A vasoreactive subset of patients with idiopathic pulmonary arterial hypertension (IPAH) was noted in Western countries, which showed favorable prognosis with treatment with high-dose calcium channel blockers. We aimed to identify IPAH patients with vasoreactivity in Korea and to show their clinical characteristics and prognosis. Methods: Data on patients who were diagnosed with IPAH at Asan Medical Center between January 1994 and March 2013 were retrospectively collected. Acute vasodilator testing was performed with inhaled nitric oxide during diagnostic right heart catheterization. A positive acute response was defined as a reduction in mean pulmonary arterial pressure (PAP) =10 mm Hg to an absolute level of mean PAP <40 mm Hg without a decrease in cardiac output. Results: Among a total of 60 IPAH patients included for analysis, 9 (15%) showed a positive acute response to acute vasodilator testing. Acute responders showed significantly lower peak velocity of a tricuspid regurgitation jet on echocardiography (4.1 ± 0.3 m/s versus 4.6 ± 0.6 m/s; P = 0.01) and significantly lower mean PAP hemodynamically (47 ± 10 mm Hg versus 63 ± 17 mm Hg; P = 0.003) than non-responders at baseline. The survival rate of acute responders was 88% at 1, 3, 5, and 10 years, respectively, which was significantly higher than that of non-responders (85%, 71%, 55%, and 40%, respectively; P = 0.029). Conclusions: Korean IPAH patients with vasoreactivity showed better baseline hemodynamic features and survival than those without vasoreactivity.

Correlation between sagittal condylar guidance angles obtained using radiographic and protrusive occlusal record methods

Oh-Kyun Kwon,Seung-Won Yang,Jee-Hwan Kim 대한치과보철학회 2017 The Journal of Advanced Prosthodontics Vol.9 No.4

PURPOSE. This study compared the SCGAs measured in three types of radiographic images (panoramic, CBCT panoramic-section, and CBCT cross-section images) with values measured using the protrusive occlusal record. MATERIALS AND METHODS. SCGAs were measured in 20 patients on a semi-adjustable articulator using the protrusive interocclusal record. Panoramic and CBCT images were obtained. SCGAs were measured on CBCT images in panoramic and cross sections. In all of the radiographic images, SCGAs were measured using the Frankfort horizontal reference line and the mean curvature line. The most-superior and most-inferior points of the curvatures were identified to determine the mean curvature line. Each measurement was performed twice by two operators independently. The data were analyzed by the t-test, Pearson’s correlation test, and Cronbach’s α using SPSS (α=.05). RESULTS. The mean right and left SCGAs were as follows: protrusive occlusal record (30.1 and 30.2 degrees, respectively), panoramic (38.9 and 38.7 degrees), CBCT panoramic sections (35.4 and 36.8 degrees), and CBCT cross sections (35.3 and 36.1 degrees). The SCGAs differed significantly among the groups. The Pearson coefficients for the correlations with the protrusive occlusal record measurements on the left and right sides were as follows: panoramic (0.834 and 0.791, respectively), CBCT panoramic-section (0.918 and 0.837), and CBCT cross-section (0.918 and 0.845) images. CONCLUSION. Strong correlations were found between SCGAs obtained using radiographic images and the protrusive occlusal record.

Poster Session : PS-1573 ; Pulmonary Vascular Diseases : Clinical Characteristics and Survival of Korean Idiopathic Pulmonary Arterial Hypertension Patients Based on Vasoreactivity

( Jee Hwan Ahn ),( Byung Ju Kang ),( Sun In Hong ),( Jung Su Lee ),( Jae Seung Lee ),( Yeon Mok Oh ),( Sang Do Lee ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

Background: A vasoreactive subset of patients with idiopathic pulmonary arterial hypertension (IPAH) was noted in Western countries, which showed favorable prognosis with treatment with high-dose calcium channel blockers. We aimed to identify IPAH patients with vasoreactivity in Korea and to show their clinical characteristics and prognosis. Methods: Data on patients who were diagnosed with IPAH at Asan Medical Center between January 1994 and March 2013 were retrospectively collected. Acute vasodilator testing was performed with inhaled nitric oxide during diagnostic right heart catheterization. A positive acute response was defined as a reduction in mean pulmonary arterial pressure (PAP) =10 mm Hg to an absolute level of mean PAP <40 mm Hg without a decrease in cardiac output. Results: Among a total of 60 IPAH patients included for analysis, 9 (15%) showed a positive acute response to acute vasodilator testing. Acute responders showed signify-cantly lower peak velocity of a tricuspid regurgitation jet on echocardiography (4.1 ± 0.3 m/s versus 4.6 ± 0.6 m/s; P = 0.01) and significantly lower mean PAP hemodynamically (47 ± 10 mm Hg versus 63 ± 17 mm Hg; P = 0.003) than non-responders at baseline. The survival rate of acute responders was 88% at 1, 3, 5, and 10 years, respectively, which was significantly higher than that of non-responders (85%, 71%, 55%, and 40%, respectively; P = 0.029). Conclusions: Korean IPAH patients with vasoreactivity showed better baseline hemodynamic features and survival than those without vasoreactivity.

Crystal structure of hexaaquamanganese(II) bis((<i>E</i>)-4-((4-(dimethylamino)phenyl)diazenyl)benzenesulfonate), C₂₈H₄₀MnN₆O₁₂S₂

Oh, In-Hwan,Kim, Jee Yeon,Park, Seong-Hun unknown 2016 ZEITSCHRIFT FUR KRISTALLOGRAPHIE NEW CRYSTAL STRUC Vol.231 No.2

<P>C28H40MnN6O12S2, monoclinic, P2(1)/c (no. 14), a = 6.211(5) angstrom, b = 7.146(5) angstrom, c = 38.895(5) angstrom, beta = 91.283(5)degrees, V = 1725.9(19) angstrom(3), Z = 2, R-gt(F) = 0.0639, wR(ref)(F-2) = 0.1094, T = 300 K.</P>

Direct Colorimetric Assay of Microcystin Using Protein Phosphatase

Oh, Hee-Mock,Lee, Seog-June,Kim, Jee-Hwan,Park, Chan-Sun,Yoon, Byung-Dae The Korean Society for Biotechnology and Bioengine 2000 Biotechnology and Bioprocess Engineering Vol.5 No.6

A new direct colorimetric assay of microcystin in water and algal samples is proposed consisting of two procedures as follows: 1) the elimination of phosphorus in the sample and concentration of microcystin using a C(sub)18 cartridge, 2) the detection of the released phosphorus by the ascorbic acid method and determination of protein phosphatase (PP) inhibition by microcystin. The optimum amounts of phosphorylase ${\alpha}$ and PP-1 in 50 ${\mu}$L concentrated sample were 50$\mu\textrm{g}$/50${\mu}$L buffer and 1.0unit/50${\mu}$L buffer, respectively, for the best assay. The pH for the maximum activity of PP-1 was 8. The minimum detectable concentration for this method was about 0.02$\mu\textrm{g}$/L, which is sufficient to meet the proposed guideline level of 1$\mu\textrm{g}$ microcystin/L in drinking water. Consequently, it would seem that the proposed direct colorimetric assay using PP is a rapid, easy, and convenient method for the detection of microcystin in water and algal samples.