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- 저자 : Ismail Aydin (검색결과 6 건)
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THE INCLUSION THEOREMS FOR GENERALIZED VARIABLE EXPONENT GRAND LEBESGUE SPACES
Aydin, Ismail,Unal, Cihan The Kangwon-Kyungki Mathematical Society 2021 한국수학논문집 Vol.29 No.3
In this paper, we discuss and investigate the existence of the inclusion L<sup>p(.),𝜃</sup> (𝜇) ⊆ L<sup>q(.),𝜃</sup> (𝜈), where 𝜇 and 𝜈 are two finite measures on (X, Σ). Moreover, we show that the generalized variable exponent grand Lebesgue space L<sup>p(.),𝜃</sup> (Ω) has a potential-type approximate identity, where Ω is a bounded open subset of ℝ<sup>d</sup>.
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Biomechanical Properties of the Cranial Dura Mater with Puncture Defects : An In Vitro Study
Aydin, Hasan Emre,Kizmazoglu, Ceren,Kaya, Ismail,Husemoglu, Bugra,Sozer, Gulden,Havitcioglu, Hasan,Arslantas, Ali The Korean Neurosurgical Society 2019 Journal of Korean neurosurgical society Vol.62 No.4
Objective : The primary aim of this investigation was to explore the nature of dura mater biomechanics following the introduction of puncture defect(s). Methods : Twenty-eight dura mater specimens were collected during autopsy from the department of forensic medicine of the authors' institution. Specimens were divided randomly into one of four groups : group I (cranial dura mater; n=7), group II (cranial dura mater with one puncture defect; n=7); group III (cranial dura mater with two puncture defects; n=7), and group IV (cranial dura mater with three puncture defects; n=7). Results : The mean${\pm}$standard deviation tensile strengths of the dura mater were $8.35{\pm}3.16$, $8.22{\pm}3.32$, $7.13{\pm}1.77$, and $6.94{\pm}1.93MPa$ for groups I, II, III, and IV, respectively. There was no statistical difference between all groups. A single, two or more punctures of the dura mater using a 20-gauge Quincke needle did not affect cranial dura tensile strength. Conclusion : This biomechanical study may contribute to the future development of artificial dura mater substitutes and medical needles that have a lower negative impact on the biomechanical properties of dura mater.
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Kizmazoglu, Ceren,Aydin, Hasan Emre,Sevin, Ismail Ertan,Kalemci, Orhan,Yuceer, Nurullah,Atasoy, Metin Ant The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.58 No.6
Background : Cerebral ischemia is as a result of insufficient cerebral blood flow for cerebral metabolic functions. Resveratrol is a natural phytoalexin that can be extracted from grape's skin and had potent role in treating the cerebral ischemia. Apoptosis, a genetically programmed cellular event which occurs after ischemia and leads to biochemical and morphological changes in cells. There are some useful markers for apoptosis like Bcl-2, bax, and p53. The last reports, researchers verify the apoptosis with early markers like Annexin V. Methods : We preferred in this experimental study a model of global cerebral infarction which was induced by bilateral common carotid artery occlusion method. Rats were randomly divided into 4 groups : sham, ischemia-reperfusion (I/R), I/R plus 20 mg/kg resveratrol and I/R plus 40 mg/kg resveratrol. Statistical analysis was performed using Sigmastat 3.5 ve IBM SPSS Statistics 20. We considered a result significant when p<0.001. Results : After administration of resveratrol, Bcl-2 and Annexin levels were significantly increased (p<0.001). Depending on the dose of resveratrol, Bcl2 levels increased, p53 levels decreased but Annexin V did not effected. P53 levels were significantly increased in ishemia group, so apoptosis is higher compared to other groups. Conclusion : In the acute period, Annexin V levels misleading us because the apoptotic cell counts could not reach a certain level. Therefore we should support our results with bcl-2 and p53.
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Kalemci, Orhan,Aydin, Hasan Emre,Kizmazoglu, Ceren,Kaya, Ismail,Yilmaz, Hulya,Arda, Nuri M The Korean Neurosurgical Society 2017 Journal of Korean neurosurgical society Vol.60 No.3
Objective : The aim of this study to investigate the normal values of erythropoietin (EPO) and neuroprotective effects of quercetin and mannitol on EPO and hematocrit levels after acute severe traumatic brain injury (TBI) in rat model. Methods : A weight-drop impact acceleration model of TBI was used on 40 male Wistar rats. The animals were divided into sham (group I), TBI (group II), TBI+quercetin (50 mg/kg intravenously) (group III), and TBI+mannitol (1 mg/kg intravenously) (group IV) groups. The malondialdehyde, glutathione peroxidase, catalase, EPO, and hematocrit levels were measured 1 and 4 hour after injury. Two-way repeated measures analysis of variance and Tukey's test were used for statistical analysis. Results : The malondialdehyde levels decreased significantly after administration of quercetin and mannitol compared with those in group II. Catalase and glutathione peroxidase levels increased significantly in groups III and IV. Serum EPO levels decreased significantly after mannitol but not after quercetin administration. Serum hematocrit levels did not change significantly after quercetin and mannitol administration 1 hour after trauma. However, mannitol administration decreased serum hematocrit levels significantly after 4 hour. Conclusion : This study suggests that quercetin may be a good alternative treatment for TBI, as it did not decrease the EPO levels.
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Kizmazoglu, Ceren,Aydin, Hasan Emre,Kaya, Ismail,Atar, Murat,Husemoglu, Bugra,Kalemci, Orhan,Sozer, Gulden,Havitcioglu, Hasan The Korean Neurosurgical Society 2019 Journal of Korean neurosurgical society Vol.62 No.6
Objective : The aim of this study was to investigate the biomechanical differences between human dura mater and dura mater substitutes to optimize biomimetic materials. Methods : Four groups were investigated. Group I used cranial dura mater (n=10), group II used $Gore-Tex^{(R)}$ Expanded Cardiovascular Patch (W.L. Gore & Associates Inc., Flagstaff, AZ, USA) (n=6), group III used $Durepair^{(R)}$ (Medtronic Inc., Goleta, CA, USA) (n=6), and group IV used $Tutopatch^{(R)}$ (Tutogen Medical GmbH, Neunkirchen am Brand, Germany) (n=6). We used an axial compression machine to measure maximum tensile strength. Results : The mean tensile strengths were $7.01{\pm}0.77MPa$ for group I, $22.03{\pm}0.60MPa$ for group II, $19.59{\pm}0.65MPa$ for group III, and $3.51{\pm}0.63MPa$ for group IV. The materials in groups II and III were stronger than those in group I. However, the materials in group IV were weaker than those in group I. Conclusion : An important dura mater graft property is biomechanical similarity to cranial human dura mater. This biomechanical study contributed to the future development of artificial dura mater substitutes with biomechanical properties similar to those of human dura mater.
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Ali Durmus,Mine Begum Alanalp,Ismail Aydin 한국유변학회 2019 Korea-Australia rheology journal Vol.31 No.2
Polyolefin blend type thermoplastic elastomers (TPEs) were prepared via melt blending method in a twin screw extruder by using isotactic polypropylene (i-PP), three different styrene-olefin triblock copolymers (SEBS-1 and SEBS-2 having a styrene content of 30 wt.% and 60 wt.%, respectively and SEEPS having a styrene content of 30 wt.%) and paraffinic oil. Composition-dependent and time-dependent viscoelastic properties of compounds were determined by various test procedures conducted in a rotational rheometer in melt state. It was found that the content of polystyrene blocks (or hard segment) in copolymers governed the rheological behaviors of compounds. It can be concluded that the increasing amount of styrene-olefin block copolymer or content of glassy domains into blend composition reduces miscibility between polyolefin and elastomer phases and also yields higher melt elasticity and viscosity, longer relaxation times, lower creep strain and compliance values at relatively longer time scale.
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