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- 검색키워드
- 저자 : Inderbir Singh (검색결과 2 건)
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Cecilia O. Alabi,Inderbir Singh,Oluwatoyin A. Odeku 한국약제학회 2018 Journal of Pharmaceutical Investigation Vol.48 No.3
In the present study, tropical starches from three botanical sources, namely millet starch obtained from the grains of Pennistum glaucum (L) R Br (family Poaceae), sorghum starch from the grains of Sorghum bicolor L. Moench (family Gramineae) and cocoyam starch from the tubers of Colocasia esculenta (L) Schott (family Araceae), have been modified and evaluated as directly compressible excipients in tramadol tablet formulations. The starches were extracted from the relevant plant parts and modified by pregelatinization followed freeze drying and used as excipients in tramadol tablets and the tablet properties compared with those made with the natural forms of the starches. The results indicate that starches from the three botanical sources vary in their properties and pregelatinization led to the modification of the physicochemical and material properties of the starches. The pregelatinized starches exhibited better flowability and compressibility than the natural starches. Tramadol tablets prepared with freeze-dried pregelatinized starches generally exhibited higher crushing strength but lower friability than those prepared with the natural starches. The rankings of the crushing strength and the disintegration and dissolution times was cocoyam > millet > sorghum starches, with tramadol tablets containing freeze-dried pregelatinized starches exhibiting significantly (p < 0.01) higher disintegration and dissolution times than tablets made with the natural forms of starches. The freeze-dried pregelatinized starches were suitable as directly compressible excipients and provided controlled release of tramadol indicating their potential application in formulations where slower drug release is desired.
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Loveleen Kaur,Ritu Raj,Ajay Kumar Thakur,Inderbir Singh 환경독성보건학회 2020 환경독성보건학회지 Vol.35 No.3
Development of modified polymers is the focused area of research for developing stable, effective, sustainable and economical polymeric materials for developing different drug delivery systems. Modification of chitosan by catechol functionalization is useful for developing chitosan derivative with the improved mucoadhesive property. Present study was designed to perform single dose acute oral toxicity on chitosan-catechol conjugates in Swiss albino mice as per international guidelines. Oral administration of modified chitosan did not exhibit any significant change in body weight, behavioural pattern, haematology, food intake and clinical symptoms in the experimental animals. In the histopathological study, no pathological changes were observed in the vital organs of mice when administered perorally with 300 mg/kg and 2,000 mg/kg body-weight doses of chitosan-catechol polymeric conjugates. Overall, it was concluded from the acute oral toxicity study that the oral administration of chitosan-catechol conjugates in mice did not produce any toxicity. Hence, chitosan-catechol conjugates could be designated and recommended as safe polymeric material for developing different drug delivery systems.
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