초음파탐상 PD-RR Test의 통계적 신뢰도 평가 (Ⅲ) : a Round Robin Test Reesult (Part Ⅲ)

박익근,박은수,김현묵,박윤원,강석철,최영환,이진호 한국비파괴검사학회 2003 학술대회 논문집 Vol.- No.1

국내 원전의 건전성 및 안전성 확보에 직결되는 자동 초음파검사의 신뢰도 및 검사시스템의 기량을 평가하기 위해 자동UT-PD RRT를 수행하였다. 수행된 RRT의 조건은 2001년 수동 PD-RRT에 적용된 설계변수와 동일하다. 본 연구에서는 자동 UT의 결함검출확률 및 오판확률과 결함크기측정에 대한 불확도 분석을 이용하여 자동 초음파검사의 통계적인 신뢰도를 평가하고 수동 UT PD-RRT의 결과와 비교하여 기량을 검증하고자 한다. 이러한 연구결과를 토대로 향후 각종 비파괴검사에 대한 RRT를 수행하여 기술수준을 파악하고 비파괴검사기술의 발전을 도모할 수 있을 것으로 판단된다.

대정맥-심방 우회술로 치료한 기질화된 혈전에 의한 하대정맥 폐쇄 : 증례 보고

문철,임훈,전훈배,염욱,윤익진,이석열,정윤섭 대한혈관외과학회 1999 Vascular Specialist International Vol.15 No.1

Suprarenal IVC obstruction occurs rarely but has various causes. Because this obstruction proceed chronically and usually has collateral circulation, if there is no IVC or hepatic vein obstruction symptom such as Budd-Chiari syndrome, operation is usually needless. However, although symptom is not combined, if malignancy can not be ruled out and there is no proper and radiologically visible collateral, mass resection with IVC wall and bypass graft should be done. 58 year-old female patient visit the hospital for IVC mass that is occasionally discovered by routine abdominal ultrasonography examination. After abdominal CT scanning and IVC venography, IVC obstructive mass between renal vein and hepatic vein was found. Patient didn't show any abnormality in hematological examination such as coagulation and platelet counts. There was no IVC obstruction symptom such as lower limb swelling. Inferior hepatic vein was abnormally dilated and this was regarded as collateral vessel for IVC obstruction. Radiologically, primary leiomyosarcoma was not ruled out and so operation was decided. Suprarenal IVC was dissected and mass was exposed. And with the use of femoral vein and right atrium, temporally veno-veno bypass was performed. Mass including IVC wall was excised and upper end of divided IVC was sutured. Lower end of divided IVC was anastomosed with 16 mm Dacron graft and graft was anastomosed with right atrium by end-to-end methods (Cavoatrial shunt). Postoperative pathologic examination revealed the mass to be organized thrombi. After 2 weeks later, follow-up IVC venography was performed and good patency was found from IVC to right atrium through artificial bypass graft and patient was discharged without complications.

Customized 3D Printed Bolus for Breast Reconstruction for Modified Radical Mastectomy (MRM)

Ha, Jin-Suk,Jung, Jae Hong,Kim, Min-Joo,Jeon, Mi Jin,Jang, Won Suk,Cho, Yoon Jin,Lee, Ik Jae,Kim, Jun Won,Suh, Tae Suk Korean Society of Medical Physics 2016 의학물리 Vol.27 No.4

We aim to develop the breast bolus by using a 3D printer to minimize the air-gap, and compare it to commercial bolus used for patients undergoing reconstruction in breast cancer. The bolus-shaped region of interests (ROIs) were contoured at the surface of the intensity-modulated radiation therapy (IMRT) thorax phantom with 5 mm thickness, after which the digital imaging and communications in mdicine (DICOM)-RT structure file was acquired. The intensity-modulated radiation therapy (Tomo-IMRT) and direct mode (Tomo-Direct) using the Tomotherapy were established. The 13 point doses were measured by optically stimulated luminescence (OSLD) dosimetry. The measurement data was analyzed to quantitatively evaluate the applicability of 3D bolus. The percentage change of mean measured dose between the commercial bolus and 3D-bolus was 2.3% and 0.7% for the Tomo-direct and Tomo-IMRT, respectively. For air-gap, range of the commercial bolus was from 0.8 cm to 1.5 cm at the periphery of the right breast. In contrast, the 3D-bolus have occurred the air-gap (i.e., 0 cm). The 3D-bolus for radiation therapy reduces the air-gap on irregular body surface that believed to help in accurate and precise radiation therapy due to better property of adhesion.

Thymosin β4 expression correlates with lymph node metastasis through hypoxia inducible factor- α induction in breast cancer

YOON, SUN YOUNG;LEE, HA REUM;PARK, YOORIM;KIM, JOO HEON;KIM, SOO YOUNG;YOON, SUK RAN;LEE, WANG JAE;CHO, BYUNG JOO;MIN, HYEYOUNG;BANG, JUNG-WOOK;PARK, HYUNJEONG;BANG, SA IK;CHO, DAEHO Sookmyung Women's University Research Institute of 2011 여성과 건강 Vol.6 No.2

Intratumoral hypoxia has been correlated with distant metastatic potential. Two hypoxia inducible factors (HIFs). HIF-1α and HIF-2α, are induced by hypoxia, and high expression of these proteins has been correlated to angiogenesis and distant metastasis. Thymosin β4 (Tβ4) is frequently highly expressed in cancer, and this overexpression correlates with malignant progression. The objective of this study was to investigate the clinical correlation of HIF-α with Tβ4 and the intracellular functional roles of Tβ4 on HIF-α activation. We examined HIF-1α, HlF-2α and Tβ4 expressions in clinical human breast carcinoma (n=70) by immunohisto-chemistry. We show that high expression of HIF-1α and HIF-2α strongly correlates with Tβ4 expression (P≤0.0001) and overexpression of Tβ4 correlates significantly with patients with lymph node metastasis (P<0.05) of human breast cancer. Additionally, we demonstrate that hypoxia up-regulates intracellular Tβ4 protein, which then affects HIF-α activity, which is the key in regulating VEGF expression. We confirmed that hypoxia-induced intracellular Tβ4 and HIF-α activities were reduced by interference of TIM expression using Tβ4 shRNA lentivirus. Vascular epidermal growth factor (VEGF)-A, a well-recognized lymphangiogenic cytokine, was also down-regulated, but VEGF-C and VEGF-D expressions were not affected. These findings suggest that the overexpression of Tβ4 is strongly associated with HIF-1α and HIF-2α expression and is also clinicopathologically involved with lymph node metastatic potential of breast cancer through the modulation of HIF-a activation and induction of VEGF-A. Ultimately, these results highlight Tβ4 as a potentially therapeutic target in malignant cancers.

Characterization of the UV Oxidation of Raw Natural Rubber Thin Film Using Image and FT-IR Analysis

( Ik Sik Kim ),( Bok Won Lee ),( Kyung Suk Sohn ),( Joohoe Yoon ),( Jung Hun Lee ) 한국고무학회 2016 엘라스토머 및 콤포지트 Vol.51 No.1

Characterization of the UV oxidation for raw natural rubber (NR) was investigated in controlled conditions through image and FT-IR analysis. The UV oxidation was performed on a thin film of natural rubber coated on a KBr window at 254 nm and room temperature to exclude the thermal oxidation. Before or after exposure to UV light, image of the NR thin film was observed at a right or tilted angle. FT-IR absorption spectra were measured in transmission mode with the UV irradiation time. The UV oxidation of NR was examined by the changes of absorption peaks at 3425, 1717, 1084, 1477, 1377, and 833 cm(-1) which were assigned to hydroxyl group (-OH), carbonyl group (-C=O), carbon-oxygen bond (-C-O), methylene group (-CH2-), methyl group (-CH3), and cis-methine group (cis-CCH3=CH-), respectively. During the initial exposure period, the results indicated that the appearance of carbonyl group was directly related to the reduction of cis-methine group containing carbon-carbon double bond (-C=C-). Most of aldehydes or ketones from carbon-carbon double bonds were formed very fast by chain scission. A lot of long wide cracks with one orientation at regular intervals which resulted in consecutive chain scission were observed by image analysis. During all exposure periods, on the other hand, it was considered that the continuous increment of hydroxyl and carbonyl group was closely related to the decrement of methylene and methyl group in the allylic position. Therefore, two possible mechanisms for the UV oxidation of NR were suggested.

飼料作物의 營養 生理에 관한 硏究

尹益錫 건국대학교 1970 學術誌 Vol.11 No.1

This experiment was designed to investigate the optimum pH for Ca++ and PO4-- intake of corn crops as a pasturage, besides the effect of NO3-N and NH4-N sources media and physiological condition o: plants. The obtained results are summerized as follows; 1.The optimum pH values for Ca++ and PO4-- intake was seemed to be 7 and 6 respectively. 2.In case of Ca++, the ion uptake was higher in NO3-N media than NO4-N while the PO4--N uptake was less in NO3-N. 3.The plants starved for 30 hours in distilled water, had poor condition for ion up take.

ADI-FDTD for the modeling and simulation of VLSI interconnects

Ik-Joon Choi,Suk-In Yoon,Jin-Woo Kim,Taeyoung Won 한국물리학회 2005 Current Applied Physics Vol.5 No.4

In this paper, we report the implementation of alternating-direction-implicit (ADI) nite-dierence time-domain (FDTD)method for modeling and simulation of VLSI interconnects in order to resolve the limitation of CourantFriedrichLevy (CFL)stability condition. It is revealed that the ADI-FDTD simulation approach is promising for understanding the electromagneticphenomena of the VLSI interconnects. The amount of signal distortion as well as cross-talks between the parallel and cross-overinterconnects has been calculated. For instance, signal distortion of 0.30.6 V with clock distortion of 0.20.4 V are measured fortwo parallel lines with 1l m spacing..

A Prospective Nationwide Study of Drug-Induced Liver Injury in Korea :

Suk, Ki Tae,Kim, Dong Joon,Kim, Chang Hoon,Park, Seung Ha,Yoon, Jai Hoon,Kim, Yeon Soo,Baik, Gwang Ho,Kim, Jin Bong,Kweon, Young Oh,Kim, Byung Ik,Kim, Seok Hyun,Kim, In Hee,Kim, Ju Hyun,Nam, Soon Woo American College of Gastroenterology 2012 The American journal of gastroenterology Vol.107 No.9

Thymosin 관4 expression correlates with lymph node metastasis through hypoxia inducible factor-관 induction in breast cancer.

Yoon, Sun Young,Lee, Ha Reum,Park, Yoorim,Kim, Joo Heon,Kim, Soo Young,Yoon, Suk Ran,Lee, Wang Jae,Cho, Byung Joo,Min, Hyeyoung,Bang, Jung-Wook,Park, Hyunjeong,Bang, Sa Ik,Cho, Daeho National Hellenic Research Foundation 2011 Oncology reports Vol.25 No.1

<P>Intratumoral hypoxia has been correlated with distant metastatic potential. Two hypoxia inducible factors (HIFs), HIF-1관 and HIF-2관, are induced by hypoxia, and high expression of these proteins has been correlated to angiogenesis and distant metastasis. Thymosin 관4 (T관4) is frequently highly expressed in cancer, and this overexpression correlates with malignant progression. The objective of this study was to investigate the clinical correlation of HIF-관 with T관4 and the intracellular functional roles of T관4 on HIF-관 activation. We examined HIF-1관, HIF-2관 and T관4 expressions in clinical human breast carcinoma (n=70) by immunohistochemistry. We show that high expression of HIF-1관 and HIF-2관 strongly correlates with T관4 expression (P??.0001) and overexpression of T관4 correlates significantly with patients with lymph node metastasis (P<0.05) of human breast cancer. Additionally, we demonstrate that hypoxia up-regulates intracellular T관4 protein, which then affects HIF-관 activity, which is the key in regulating VEGF expression. We confirmed that hypoxia-induced intracellular T관4 and HIF-관 activities were reduced by interference of T관4 expression using T관4 shRNA lentivirus. Vascular epidermal growth factor (VEGF)-A, a well-recognized lymphangiogenic cytokine, was also down-regulated, but VEGF-C and VEGF-D expressions were not affected. These findings suggest that the overexpression of T관4 is strongly associated with HIF-1관 and HIF-2관 expression and is also clinicopathologically involved with lymph node metastatic potential of breast cancer through the modulation of HIF-관activation and induction of VEGF-A. Ultimately, these results highlight T관4 as a potentially therapeutic target in malignant cancers.</P>

Insufficient Knowledge of Korean Gastroenterologists Regarding the Vaccination of Patients with Inflammatory Bowel Disease

( Yoon Suk Jung ),( Jung Ho Park ),( Hong Joo Kim ),( Yong Kyun Cho ),( Chong Il Sohn ),( Woo Kyu Jeon ),( Byung Ik Kim ),( And Dong Il Park ) 대한소화기학회 2014 Gut and Liver Vol.8 No.3

Background/Aims: There is an increased risk for inflammatory bowel disease (IBD) patients to develop infections due to the use of immunomodulators and biologics. Several infections are preventable by immunizations. This study investigated the knowledge and awareness of Korean gastroenterologists regarding the vaccination of patients with IBD. Methods: A self-reported questionnaire was sent by e-mail to the faculty members of tertiary hospitals. Gastroenterologists were asked ten questions regarding the immunization of patients with IBD. A total of 56 gastroenterologists completed the questionnaire. Results: A majority of gastroenterologists (>60%) had rarely or never recorded an immunization history from their patients with IBD. Moreover, 50% to 70% of the gastroenterologists did not know that live vaccines should be avoided in immunosuppressed patients. The most commonly mentioned resistance to vaccinations was “the lack of concern and knowledge regarding vaccination.” Gastroenterologists more frequently asked about the immunization history of influenza, pneumococcal, hepatitis A, and hepatitis B vaccines and recommended these vaccines more often than others. Conclusions: Korean gastroenterologists’ awareness and knowledge regarding the vaccination of patients with IBD were very poor. Intensive educational programs on immunization guidelines directed toward gastroenterologists who care for patients with IBD are required to ensure that these patients receive the necessary vaccinations.