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RISS 인기검색어
- 검색키워드
- 저자 : I. Nagy (검색결과 5 건)
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Howaida I. Abd-Alla,Nagwa M. M. Shalaby,Manal A. Hamed,Nagy Saba El-Rigal,Samira N. Al-Ghamdi,Jalloul Bouajila 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.1
Three sesquiterpene lactones [two germacranolides (micranthin and sintenin) and one guaianolide (4b,10adihydroxy- 5b,7b,8bH-guaia-1,11(13)dien-12,8a-olide)] and four derivatives of 3-methoxy flavones (santin, quercetagetin- 3,6,30-trimethyl ether, quercetagetin-3,6-dimethyl ether, and 5,7 dihydroxy 3,30,40-trimethoxy flavone) were isolated from the ethyl acetate extract (EAE) of the aerial parts of Achillea biebersteinii Afan. (Asteraceae). Evaluation of protective and therapeutic effects of EAE against ethanol-induced gastric ulcer in rats was carried. Antiulcer activity evaluation was done through measuring ulcer indices, stomach acidity, gastric volume and lesion counts. Oxidative stress markers; malondialdehyde, glutathione and superoxide dismutase were also estimated. The work was extended to determine the histopathological assessment of the stomach. Gastric ulcer exhibited a significant elevation of the ulcer index and oxidative stress markers. The extract attenuated these increments and recorded protective and therapeutic effects against gastric ulcer. Hyperglycaemia increases the mucosal susceptibility to ulcerogenic stimuli and predisposes gastric ulceration. In vitro a-amylase inhibitory assay was applied to evaluate the post prandial antihyperglycaemia activity. The result showing that the EAE has the ability to reduce starch-induced postprandial glycaemic excursions by virtue of potent intestinal a-amylase inhibitory activity. These findings demonstrated the remarkable potential of A. biebersteinii as valuable source of antiulcer agent with post prandial hyperglycaemia lowering effect.
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P. Bartal,J. Hamar,I. Nagy,H. Funato,Y. Nishida 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5
Today’s society is more energy-hungry than ever. Despite the progress made both on research and technological level and the wide acceptance of energy efficient and “green” technologies and innovations, the global energy consumption figures are on the rise. It is not sufficient to have efficient consumers, the various conversion stages along the distribution network have to be highly efficient too, in order to minimize losses. Another problem in the way of optimum efficiency is the wide range of voltages required by the actual loads. The paper proposes a way for improving the efficiency in the DC/DC converter field by selecting automatically the number of turned on or off converters supplying the current consumer just connected to the DC bus. Several DC/DC converters equipped with intelligence are connected in parallel to the DC bus and only the number of converters required to ensure optimum efficiency will be in operation at a given time. This is possible due to the intelligent agent based digital control implemented into the microcontroller driving the converters. The decisions leading to optimal operation will be taken by the communicating agents through negotiations. Furthermore, the converters will be able to gather information on the load they serve. This will make it possible to determine the voltage level and current requirements of the load, adjusting the operation of the converter(s) to it. After simulation a demonstration unit has been built in the lab, using four converters connected in parallel. Results from simulation and laboratory measurements are presented.
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Gene network and canonical pathway analysis in prostatecancer: a microarray study
Hakan Savli,Attila Szendrӧi,Imre Romics,Balint Nagy 생화학분자생물학회 2008 Experimental and molecular medicine Vol.40 No.2
The molecular mechanism playing a role in the development of prostate cancer (PCA) is not well defined. We decided to determine the changes in gene expression in PCA tissues and to compare them to those in noncancerous samples. Prostate tissue samples were collected by needle biopsy from 21 PCA and 10 benign prostate hyperplasic (BPH) patients. Total RNA was isolated, cDNA was synthesized, and gene expression levels were determined by microarray method. In the progression to PCA, 738 up-regulated and 515 downregulated genes were detected in samples. Analysis using Ingenuity Pathway Analysis (IPA) software revealed that 466 network and 423 functions-pathways eligible genes were up-regulated, and 363 network and 342 functions-pathways eligible genes were down-regulated. Up-regulated networks were identified around IL-1β and insulin-like growth factor-1 (IGF-1) genes. The NFKB gene was centered around two upand down-regulated networks. Up-regulated canonical pathways were assigned and four of them were evaluated in detail: acute phase response, hepatic fibrosis, actin cytoskeleton, and coagulation pathways. Axonal guidance signaling was the most significant down-regulated canonical pathway. Our data provide not only networks between the genes for understanding the biologic properties of PCA but also useful pathway maps for future understanding of disease and the construction of new therapeutic targets. The molecular mechanism playing a role in the development of prostate cancer (PCA) is not well defined. We decided to determine the changes in gene expression in PCA tissues and to compare them to those in noncancerous samples. Prostate tissue samples were collected by needle biopsy from 21 PCA and 10 benign prostate hyperplasic (BPH) patients. Total RNA was isolated, cDNA was synthesized, and gene expression levels were determined by microarray method. In the progression to PCA, 738 up-regulated and 515 downregulated genes were detected in samples. Analysis using Ingenuity Pathway Analysis (IPA) software revealed that 466 network and 423 functions-pathways eligible genes were up-regulated, and 363 network and 342 functions-pathways eligible genes were down-regulated. Up-regulated networks were identified around IL-1β and insulin-like growth factor-1 (IGF-1) genes. The NFKB gene was centered around two upand down-regulated networks. Up-regulated canonical pathways were assigned and four of them were evaluated in detail: acute phase response, hepatic fibrosis, actin cytoskeleton, and coagulation pathways. Axonal guidance signaling was the most significant down-regulated canonical pathway. Our data provide not only networks between the genes for understanding the biologic properties of PCA but also useful pathway maps for future understanding of disease and the construction of new therapeutic targets.
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Wall to liquid mass transport and diffusion controlled corrosion in fixed bed reactors
M.H. Abdel-Aziz,M. Bassyouni,I.A.S. Mansour,A. Nagi 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.5
The diffusion controlled corrosion at the inner wall of a fixed bed reactor was studied in terms of the wall to liquid mass transfer coefficient. Variables studied are solution flow rate, physical properties, and packing size and geometry. The effect of drag reducing polymers on the rate of mass transfer and on the rate of corrosion was studied. The presence of the drag reducing polymer decreased the rate of both mass transfer and corrosion by a factor ranging from 8.92% to 39.47%. All variables were correlated by dimensionless equations. Possible applications of these data in heat transfer were highlighted. 2013 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V.
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