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양파(Allium cepa L.) 추출물이 Tyrosinase 유전자 발현에 미치는 효과
조남철,윤연희,이혜진,손현정,김양경,최근희,나명석,조영권,이황희,진종언 한국식품영양학회 2001 韓國食品營養學會誌 Vol.14 No.3
Melanin 생성에 관여하는 tyrosinase 유전자의 발현을 억제하는 물질을 탐색하고자 tyrosinase promoter를 지닌 Bl6 mouse melanoma cell해 앙파 methanol 추출물을 처리한 바 양파 methanol 추풀물은 10.0㎍/ml, 100.0 ㎍/ml, 1.0 ㎎/ml의 농도에서 대조군에 비해서 약 15%, 23% 57%의 억제효과를 나타냈으며 세포생존율은 1.0 ㎍/ml, 10.0 ㎍/ml, I00.0 ㎍/ml, 1.0㎎/ml의 농도에서 약 126 %, 92%. 85%, 64%로서 세포독성이 낮게 나타났다. Ethyl acetate, butyl alcohol, 그리고 물 용매 분획물은 tyrosinase 유전자의 발현물 억제하는 효과가 없었지만 methylene chloride 용해 분획물은 10.0 ㎍/ml과 100.0 ㎍/ml의 농도에서 약 37%와 35%의 발현율을 나타냄으로서 대조군에 비해 크게 억제하였다. Onion(Allium cepa L,) extract by methanol repressed the expression of tyrosinase gene of B16 mouse melanoma cell containing tyrosinase promoter. 10.0 ㎍/ml, 100.0 ㎍/ml, 1.0 ㎎/ml of the extract repressed expression of tyrosinase gene about 15%, 23%, and 57%, respectively, compared with control. In the MTT assay, the same extract exhibited low cytotoxicity at 1.0 ㎍/ml, 10.0 ㎍/ml, 100.0 ㎍/ml, and 1.0 ㎎/ml, respectively. The fractions of ethyl acetate, butyl alcohol, and water did not showed the repressive effect on the expression of tyrosinase gene, but the fraction of methylene chloride repressed highly at 10.0 ㎍/ml and 100.0 ㎍/ml.
Hyejin Lee,Jinhee Kim,Jun Yeon Park,Ki Sung Kang,Joeng Hill Park,Gwi Seo Hwang 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.3
Background: Heat-processed ginseng, sun ginseng (SG), has been reported to have improved therapeutic properties compared with raw forms, such as increased antidiabetic, anti-inflammatory, and antihyperglycemic effects. The aim of this study was to investigate the antiobesity effects of SG through the suppression of cell differentiation and proliferation of mouse 3T3-L1 preadipocyte cells and the lipid accumulation in Caenorhabditis elegans. Methods: To investigate the effect of SG on adipocyte differentiation, levels of stained intracellular lipid droplets were quantified by measuring the oil red O signal in the lipid extracts of cells on differentiation Day 7. To study the effect of SG on fat accumulation in C. elegans, L4 stage worms were cultured on an Escherichia coli OP50 diet supplemented with 10 mg/mL of SG, followed by Nile red staining. To determine the effect of SG on gene expression of lipid and glucose metabolism-regulation molecules, messenger RNA (mRNA) levels of genes were analyzed by real-time reverse transcription-polymerase chain reaction analysis. In addition, the phosphorylation of Akt was examined by Western blotting. Results: SG suppressed the differentiation of 3T3-L1 cells stimulated by a mixture of 3-isobutyl-1-methylxanthine, dexamethasone, and insulin (MDI), and inhibited the proliferation of adipocytes during differentiation. Treatment of C. elegans with SG showed reductions in lipid accumulation by Nile red staining, thus directly demonstrating an antiobesity effect for SG. Furthermore, SG treatment downregulated mRNA and protein expression levels of peroxisome proliferator-activated receptor subtype g(PPARg) and CCAAT/enhancer-binding protein-alpha (C/EBPa) and decreased the mRNA level of sterol regulatory element-binding protein 1c in MDI-treated adipocytes in a dose-dependent manner. In differentiated 3T3-L1 cells, mRNA expression levels of lipid metabolism-regulating factors, such as amplifying mouse fatty acid-binding protein 2, leptin, lipoprotein lipase, fatty acid transporter protein 1, fatty acid synthase, and 3-hydroxy-3-methylglutaryl coenzyme A reductase, were increased, whereas that of the lipolytic enzyme carnitine palmitoyltransferase-1 was decreased. Our data demonstrate that SG inversely regulated the expression of these genes in differentiated adipocytes. SG induced increases in the mRNA expression of glycolytic enzymes such as glucokinase and pyruvate kinase, and a decrease in the mRNA level of the glycogenic enzyme phosphoenol pyruvate carboxylase. In addition, mRNA levels of the glucose transporters GLUT1, GLUT4, and insulin receptor substrate-1 were elevated by MDI stimulation, whereas SG dose-dependently inhibited the expression of these genes in differentiated adipocytes. SG also inhibited the phosphorylation of Akt (Ser473) at an early phase of MDI stimulation. Intracellular nitric oxide (NO) production and endothelial nitric oxide synthase mRNA levels were markedly decreased by MDI stimulation and recovered by SG treatment of adipocytes. Conclusion: Our results suggest that SG effectively inhibits adipocyte proliferation and differentiation through the downregulation of PPARg and C/EBPa, by suppressing Akt (Ser473) phosphorylation and enhancing NO production. These results provide strong evidence to support the development of SG for antiobesity treatment.
Hyejin Hyeon,Boram Go,Ho Bong Hyun,Sung Chun Kim,Seon-A Yoon,So Yeon Oh,Yong-Hwan Jung,Young-Min Ham 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In this study, the essential oil (EO) and the major non-volatile metabolites in white flower buds of Magnolia denudata and violet flower buds of Magnolia liliiflora were analyzed using GC-MS and HPLC. The dominant EO compounds found in the flower buds were monoterpene hydrocarbons (MO), e.g. sabinene (15.8-14.6%), β-myrcene (17.2-9.9%), and β-pinene (12.9-7.7%). Univariate and multivariate analysis were subsequently performed to reveal the relationships between EO compounds and non-volatile metabolites in white and violet flower buds. The results revealed that most of monoterpenes and phenolic acids in the white flower buds, such as sabinene, β-pinene, and rutin, were found to be significantly higher compared to violet flower buds. Furthermore, hierarchical clustering analysis of correlation coefficients suggested a positive correlation between MO and phenolic compounds. Our findings revealed that the metabolic patterns of both EO and non-volatile compounds could reflect the metabolic characteristics of the different colored flower buds. Further studies will be conducted to investigate the biological activities derived from EO and non-volatile compounds.
Newly developed care food enhances grip strength in older adults with dysphagia: a preliminary study
Hyejin Han,Yoonhee Park,Hyeji Kwon,Yeseung Jeong,Soyoung Joo,Mi Sook CHO,Ju Yeon Park,Hee-Won Jung,Yuri Kim 한국영양학회 2023 Nutrition Research and Practice Vol.17 No.5
BACKGROUND/OBJECTIVES: Maintaining total muscle mass in the older adults with swallowing difficulty (dysphagia) is important for preser ving swallowing function. Increasing protein intake can help sustain lean body mass in the older adults. The aim of this study was to evaluate the effect of various high-protein texture-modified foods (HPTMFs) on muscle mass and perform dietar y assessment in ≥ 65-yrs-old patients with dysphagia. SUBJECTS/METHODS: Participants (n = 10) received the newly developed HPTMFs (average 595.23 ± 66.75 kcal/day of energy, 54.22 ± 6.32 g/day of protein) for 10 days. Relative hand- grip strength (RHS), mid-upper arm circumference (MUAC), body composition, mini nutritional assessment (MNA), mini dietar y assessment (MDA), and Euro Quality-of-Life questionnaire 5-dimensional classification (EQ-5D) were assessed. RESULTS: After 10 days, an increase in MUAC (26.36 ± 2.35 cm to 28.50 ± 3.17 cm, P = 0.013) and RHS (0.38 ± 0.24 kg/kg body weight to 0.42 ± 0.22 kg/kg body weight, P = 0.046) was obser ved. Although MNA, MDA, EQ-5D, subjective health status, muscle mass, and calf circumference showed a tendency to increase after inter vention, no significant differences were found. CONCLUSIONS: These results suggest that the HPTMFs can be used for improving the nutritional and health status in patients with dysphagia.
Hyejin Sim,Ji Hyeon Ahn,Jae-Chul Lee,Jung Hoon Choi,Ki Yeon Yoo,Choong Hyun Lee,Joon Ha Park,Tae-Kyeong Lee,Moo-Ho Won 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Angelica gigas Nakai root contains decursin which exerts beneficial properties such as anti-amnesic and anti-inflammatory activities. Until now, however, the neuroprotective effects of decursin against transient ischemic injury in the forebrain have been insufficiently investigated. Here, we revealed that post-treatment with decursin and the root extract saved pyramidal neurons in the hippocampus following transient ischemia for 5 minutes in gerbil forebrain. Through HPLC, we defined that decursin was contained in the extract as 7.3 ± 0.2%. Based on this, we post-treated with 350 mg/kg extract which is corresponding dosage of 25 mg/kg decursin that exerted neuroprotection in gerbil hippocampus against the ischemia. In addition, behavioral tests were conducted to evaluate ischemia-induced dysfunctions via tests of spatial memory and learning memory, and post-treatment with the extract and decursin attenuated ischemia-induced memory impairments. Furthermore, we carried out histochemistry, immunohistochemistry and double immunohistofluorescence. Pyramidal neurons located in the subfield cornu ammonis 1 (CA1) among the hippocampal subfields were dead at 5 days after the ischemia; however, treatment with the extract and decursin save the pyramidal neurons after ischemia. IgG, which is not found in the parenchyma in normal brain tissue, was apparently shown in CA1 parenchyma from 2 days after the ischemia, but IgG leakage was dramatically attenuated in the CA1 parenchyma treated with the extract and decursin. Furthermore, astrocyte end feet, which are a component of the blood-brain barrier (BBB), were severely damaged at 5 days after the ischemia, however, post-treatment with the extract and decursin dramatically attenuated the damage of the endfeet. Based on these findings, we suggest that Angelica gigas Nakai root containing decursin can be employed as pharmaceutical composition to develop therapeutic strategy for brain ischemic injury.
Yeon Tae Choi,Hyejin Kang,Min Han Kim 한국지방정부학회 2015 한국지방정부학회 학술대회자료집 Vol.2015 No.동계
The aim of this article is to examine the influence of the level of citizens’ usage of the G4C portal system on trust in central and local government agencies, as there is an ever-increasing belief that e-government service delivery through the civil petition service portal enhances the efficiency, transparency, and equity of public administration, and such enhancement leads to higher level of citizen satisfaction and compliance as well as greater trust in government. By analyzing the clickstream data collected from South Korean citizens having experiences using the G4C portal system, the relationship between e-government usage and trust in central and local government agencies was scrutinized. The results of the multi-regression analysis suggest that the citizens’ usage of the G4C portal has a catalytic effect on strengthening trust in government. That is, when more citizens experience the convenience of e-government, there is an overall increase of trust in government agencies, therefore, this study concludes that e-government is a powerful means to elevate citizens’ trust in government.