간세포암의 고주파 열치료 후 천자침 경로를 통한 전이 1례

조영완,박석주,진한영,김준영,이재익,강명주,박정하,윤정희,박성재,지삼룡,이연재,이상혁,설상영 인제대학교 2006 仁濟醫學 Vol.27 No.-

Radiofrequency ablation(RFA), as a form of minimally invasive therapy for hepatocellular carcinoma, has become an important treatment modality. Because of limitation of surgery, RFA has become standard therapy for hepatocellular carcinoma in some situations. But there are some complications of RFA such as bleeding, infection, hematoma, adjacent organ thermal damage including intestinal perforation, needle track seeding, and so on. There are few reports in the literature that systematically evaluate the incidence of needle tract seeding and its associated risk factors. And only 2 cases of needle tract seeding of hepatocellular carcinoma after RFA were reported in Korea. We report a case of needle tract seeding of hepatocellular carcinoma after RFA.

複合 韓藥劑 淸籬滋坎湯의 抗癌效果 및 作用機轉 糾明

Cho, Kyung-Sam,Kim, Si-Young,Park, Jai-Kyung,Choi, Seung-Hoon,Chung, Se-Young,Yoon, Hwi-Joong 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung Sam Cho¹Si Young Kim¹, Jai Kyung Park²,Seung Hoon Choi³,Se Young Chung⁴, Hwi Joong Yoon¹¹College of Medicine, ²East-West Medical Research Institute, ³College of Oriental Medicine, ⁴College of Pharmacology, Kyung Hee University,Seoul, Korea. The Anti-cancer Effect of Oriental Medicine Chung-Ri-Ja-Gam-Tang in the Mouse with Metastatic Lung Cancer. Proceedings of International Symposium on East-West Medicine, Seoul. 231-243, 1999.-The oriental medicine Chung-Ri-Ja-Gam-Tang is an herbal medicine which has been used for pulmonary diseases and known as having immune stimulatory effects. It has been known effective in lung cancer. So we studied the effects and the mechanisms of this herbal medicine it the mouse with metastatic lung cancer. The metastatic lung cancer of the mouse was produced with melnoma cell line(B16BL/6).5×10□/mouse tumor cells were injected intravenously to the CDF1 mouse via tail vein. The mice were divided 4 groups. The first group was treated with 50mg/kg extract of Chung-Ri-Ja-Gam-Tang per oral for 10 days after cancer cell injection, second group treated with saline after cancer cell injection, the third group with medicine without cancer cell, and the last group with saline only. After 10 days treatments some of the mice were scarificed and the lung and spleen was removed. The survival duration, weight change, the number of metastatic cancer nodule of the lung, the NK cell activity, the capacity of cytokines(INF-γ,INF-α,IL-2) production and the proliferation activities of mouse lymphocytes were measured. The surival times of the group 1 mice were longer and the weight loss was less than the group 2 significantly. The number of the metastatic nodule of the lung were decresed in the group 1 than the group 2. The production of INF-γ,was increase in group 2 than group 3 and 4, IL-2 production was increased in group 1 than group 2,3,4 significantly. There was no difference in TNF- α production and proliferation activity of lymphocyte in each group. The NK cell activity was significantly increased in group 1 than group 2,3,4. We conclude that the Chung-Ri-Ja-Gam-Tang has the effect of increasing the NK cell activity of the CDF1 mouse with metastatic lung cancer(B16BL/6). And it is suggested that the increased production of the IL-2 is the mechanisms of enhanced NK cell activity.

의자차 정추진 방식과 역추진 방식에서상지 근전도 신호와 생리적 부담지수의 비교

박은영,조상현,이충휘,이영희 大韓再活醫學會 1999 Annals of Rehabilitation Medicine Vol.23 No.3

등속성 운동 시 근전도 주파수 분석에서 얻은 피로지수의 특성

권오윤,이충휘,조상현,이영희,원종임,박정미 한국전문물리치료학회 2001 한국전문물리치료학회지 Vol.8 No.3

In rehabilitation programs involving muscle re-education and endurance exercise, it is necessary to confirm when fatigue occurs. It is also necessary to quantify fatigue, to confirm whether the muscle has been exercised sufficiently. In general, as fatigue occurs, the force-generating ability of the muscle is reduced. If the median frequency (MDF) obtained from electromyograrn (EMG) power spectrum is correlated highly with work, then the timing and degree of fatigue may be confirmed. This study examined the relationship between work and MDF obtained from the EMG power spectrum during repetitive isokinetic exercise. Surface EMG signals were collected from biceps brachii and vastus lateralis of 52 normal subjects (26 males, 26 females) at 120˚/sec and 60˚/sec while performing an isokinetic exercise. The exercise was finished at 25% of peak work. MDF data was obtained using a moving fast Fourier transformation (FPT), and random noise was removed using the inverse FPT, then a new MDF data was obtained from the main signal. There was a high correlation between work and MDF during repetitive isokinetic exercise in the biceps brachii and vastus lateralis of males and the biceps Brachii of temales (r=.50∼.77). However, there was a low correlation between work and MDF in the vastus lateralis of females (r=.06∼.19).

SWS 490A 강의 용접 열영향부 음향방출 특성에 대한 연구(1)

이장규,우창기,박성완,윤종희,조진호,김봉각,구영덕 한국공작기계학회 2004 한국생산제조학회지 Vol.13 No.4

The object of this study is to investigate the effect of compounded welding through the AE(Acoustic Emission) characteristics for weld HAZ(Heat Affected Zone) under the static tensile test. This study was carried out an SWS 490A, high tension steel for electric shield metal arc welding(SMAW), CO₂gas arc welding and TIG welding. Data displays are based on the measured parameters of the AE signals, along with environmental variables such as time and load. The accumulated AE event curve of HAZ definitely have the point of inflection subject to tensile test. The results of the tensile test of HAZ come out electric shield arc welding > CO₂ gas arc welding >TIG welding in case of single welding, but generally the tensile test of HAZ come out electric shield arc welding > TIG welding > CO₂ gas arc welding. These history plots give us useful and powerful information to analyze the results of material evaluation testing.

인천 인현동 호프집 화재 피해자 분석

최정태,안무업,안희철,최영미,정재봉,서정열,유기철,이삼우,박석현,조준휘,김성환,김아진,송근정 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Purpose : This study was conducted to develop field triage, transportation, distribution, and prehospital care at a fire disaster by analyzing the victims of the fore that broke out at a bar in Incheon. Method : We analyzed the cases of the victims of a fire in Incheon in Oct. 1999. We determined the primary care hospital, the arrival time, the burn size, the outcome, and the injury type from the medical records, the concerned organ records, and interviews with concerned persons. Result : The total number of victims was 137: 56 prehospital deaths, 1 hospital death, and 80 survivals. The Pearson correlation coefficient between the burn size and the severity was -0.175. There were 121(89.6%) cases of inhalation injury, 59 (43.7%) cases of flame burns, 66 (48.9%) cases of hypoxic brain damage, and 16 (11.9%) cases involving other types of injury. Conclusion : The causes of death of the fire victims were inhalation injury and hypoxic brain damage due to CO poisoning and other toxic inhalants. We propose the use of a simple triage and rapid treatment(START) system and a reassessment the delayed category in fire disasters.

음향방출 신호를 이용한 SWS 490A 고장력강의 접합성 평가에 대한 실험적 연구

이장규,우창기,윤종희,조진호,조대희,박성완,김봉각,구영덕 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

The object of this study is to investigate the effect of joinability by using acoustic emission (AE) signals and doing a pattern recognition for weld heat affected zone (HAZ) in tensile testing. This study was carried out an SWS 490A high tension steel for electric shielded metal arc welding (SMAW), CO₂ gas arc welding and TIG welding. And correspondingly, the root openings are 3, 4 and 2.8㎜. The results of the tensile test of weld HAZ come out electric shield arc welding > CO₂ gas arc welding > TIG welding in case of single welding. It is believed that this is a phenomenon where difference of its root opening or base metal thickness. Also, the technique of AE is ideally suited to study variables which control time and stress dependent fracture or damage process in metallic materials.

야생식물 중독의 임상 양상

옥택근,박찬우,조준휘,천승환,이승용,김성은,최기훈,배지훈,서정열,안희철,안무업,조병렬,김용훈,Ok, Taek-Gun,Park,, Chan-Woo,Cho, Jun-Hwi,Cheon, Seung-Whan,Lee, Seung-Young,Kim,, Sung-Eun,Choi, Ki-Hoon,Bae, Ji-Hoon,Seo, Jeong-Yeul,Ahn, Hee-Cheo 대한임상독성학회 2005 대한임상독성학회지 Vol.3 No.2

Purpose: With the recent boom in 'eating healthy', many adults are interested in dieting to prevent future diseases. However only well trained experts can distinguish between what are edible vegetables and herbs from their poisonous look-alikes. In cases where a patient unknowingly ingests a poisonous herb, is caught off guard by the poisonous side effects that occur because of their lack of knowledge of what they have ingested. This paper will focus on the need to educate the public about the risks involved with ingesting wild vegetables and herbs and study the emergency diagnosis and treatment of poisoned patients that enter the emergency room. Method: This study was done in the spring of 2004 (from March to May) in the Kangwon Young-Seo districts of Korea. 15 subjects used in this study, entered the emergency room showing signs of toxic symptoms. Data was collected by examining subject's records. Additional data was collected by collaborating with physicians in the hospital that diagnosed and treated the subjects. Identifying the poisonous vegetable or herb is the first step to proper diagnosis and treatment. Subjects admitted to the emergency room, underwent a battery of tests: laboratory examination, ECG, radiological exam and etc. Results: The demographics of the study encompassed subjects with the average age of $50{\pm}19$ years old. There were 10 men and 5 women. Common symptoms of this study included; gastrointestinal symptoms such as nausea, vomiting, epigastric pain and so on. In the case of Caltha palustris ingestion, additional symptoms were present; bradycardia and hypotension which lasted for a long time. While cases that ingested Scopolia parviflora had little effect on vital signs but manic episodes lasted for about three days. Veratrum patulum ingestion showed signs of bradycardia and hypotension but contrary to Caltha palustris recovery was shorten by treating with dopamine. However, dizziness, headache and paresthesia of the extremities continued for a long time. Finally Sium ninsi ingestion showed visual disturbance, paresthesia of the extremities, dizziness as their initial symptoms. Conclusion: The risks involved with ingesting wild plants without the proper knowledge can lead to serious side effects and steps need to be taken to educate the public. In addition, all emergency physicians need to have a working knowledge of the symptoms and signs associated with ingesting toxic wild plants and need to treat accordingly.

Comparison of the immunoreactivity of Trx2/Prx3 redox system in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia.

Yan, Bing Chun,Park, Joon Ha,Ahn, Ji Hyeon,Lee, Young Joo,Lee, Tae Hun,Lee, Choong Hyun,Cho, Jun Hwi,Kim, Myong Jo,Kim, Tae Young,Kang, Il-Jun,Won, Moo-Ho Kluwer Academic/Plenum Publishers 2012 Neurochem Res Vol.37 No.5

<P>In the present study, we compared the immunoreactivities and levels of Trx/prx redox system, thioredoxin 2 (Trx2), thioredoxin reductase 2 (TrxR2) and peroxiredoxin 3 (Prx3), as well as neuronal death in the hippocampal CA1 region between the adult and young gerbil after 5 min of transient cerebral ischemia. At 4 days post-ischemia, pyramidal neurons (about 90%) in the adult stratum pyramidale of the CA1 region showed 'delayed neuronal death (DND)'; however, at this time point, few pyramidal neurons showed DND in the young stratum pyramidale. At 7 days post-ischemia, about 56% of pyramidal neurons showed DND in the young stratum pyramidale. The immunoreactivities of all the antioxidants in the young sham-group were similar to those in the adult sham-group. At 4 days post-ischemia, the immunoreactivity of TrxR2, not Trx2 and Prx3 in the adult ischemia-group was dramatically decreased in CA1 pyramidal neurons. At this time point, the immunoreactivities of all the antioxidants in the young ischemia-group were apparently increased compared to the adult ischemia-group. From 7 days pots-ischemia, non-pyramidal cells showed the immunoreactivities of all the antioxidants in the ischemic CA1 region; however, in the young ischemia-groups, the immunoreactivities were much lower than those in the adult ischemia-groups. In brief, our results showed that the immunoreactivities of Trx2, TrxR2 and Prx3 were dramatically increased in CA1 pyramidal neurons of the young ischemia-groups at 4 days post-ischemia compared to those in the adult ischemia-groups induced by transient cerebral ischemia.</P>

Long-term Outcome of Microscopic Transsphenoidal Surgery for Prolactinomas as an Alternative to Dopamine Agonists

Park Kawngwoo,Park Kwang Hyon,Park Hye Ran,Lee Jae Meen,Kim Yong Hwy,Kim Dong-Young,Won Tae-Bin,Kong Sung Hye,Kim Jung Hee,Shin Chan Soo,Paek Sun Ha 대한의학회 2021 Journal of Korean medical science Vol.36 No.15

Background: Although long-term dopamine agonist (DA) therapy is recommended as a first-line treatment for prolactinoma, some patients may prefer surgical treatment because of the potential adverse effects of long-term medication, or the desire to become pregnant. This study aimed to determine whether surgical treatment of prolactinomas could be an alternative to DA therapy. Methods: In this retrospective study, 96 consecutive patients (74 female, 22 male) underwent primary pituitary surgery without long-term DA treatment for prolactinomas at a single institution from 1990 to 2010. All patients underwent primary surgical treatment in the microscopic transsphenoidal approach (TSA). Results: The median age and median follow-up period were 31 (16–73) years and 139.1 (12.2–319.6) months, respectively. An initial overall remission was accomplished in 47.9% (46 of 96 patients, 33 macroadenomas, and 13 microadenomas) of patients. DA dose reduction was achieved in all patients after TSA. A better remission rate was independently predicted by lower diagnostic prolactin levels and by a greater extent of surgical resection. Overall remission at the last follow-up was 33.3%, and the overall recurrence rate was 30.4%. The permanent complication rate was 3.1%, and there was no mortality. Conclusion: TSA can be considered a safe and potentially curative treatment for selective microprolactinomas as an alternative to treatment with a long-term DA.