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인삼(人蔘) 각(各) Fraction이 Nembutal, Chlorpromazine 및 Reserpine 투여(投與)로 인(因)한 Mouse체온하강(體溫下降)에 미치는 영향(影響)
홍사악(Hong, Sa-Ack),조항영(Cho, Hang-Young),홍순근(Hong, Soon-Keun) 대한약리학회 1969 대한약리학잡지 Vol.5 No.2
Saponin, essential oil, fat oil and alkaloidal fraction were fractionated from the ethanol extract of fanax ginseng. Effect of each fraction of Panax ginseng upon the temperature response induced by reserpine, chlorpromazine and nembutal was investigated in mice, so as to secure some hidden facets of each fraction of Panax ginseng acting upon central nervous system. The authors could arrive at some results, that is: (1) Inhibitory effect of Panax ginseng upon temperature decline induced by nembutal and chlorpromazine and potentiating action upon hyperthermia induced by reserpine reside mainly in saponin fraction and slightly in essential oil fraction. (2) The effect of Ginseng saponin on temperature response in nice seems to be related with the liberation of serotonin and histamine.
Mitochondria의 Calcium Uptake에 미치는 Ouabain의 영향
홍사악(Hong, Sa-Ack),박찬웅(Park, Chan-Woong),김명석(Kim, Myung-Suk),정명희(Chung, Myung-Hee) 대한약리학회 1972 대한약리학잡지 Vol.8 No.1
Many studies on the mechanism of the inotropic action of cardiac glycosides have shown the possible intimate relationship between the mobilization of intracellular calcium and inotropic effect. Evidence obtained from recent studies suggests that cardiac glycosides may increase the intracellular Ca<sup>++</sup> concentration through the release of this ion from cellular or intracellular membrane. It seemed imperative to study the effect of ouabain on the interaction between mitochondria and Ca<sup>++</sup>, because mitochondria are known to have a rather powerful Ca<sup>++</sup> pump mechanism which may have an important role on the regulation of intracellular Ca<sup>++</sup> concentration. The present investigations was made into the effect of ouabain on Ca<sup>++</sup> untake of mitochondria in the presence of ATP and its dependence on K<sup>+</sup> and Na<sup>+</sup> in the medium. The results are summarized as follows: 1. The rate of rise in the turbidity of superprecipitation was solely influenced by ionic strength of the medium, not by the species of ion, i.e. Na<sup>+</sup> or K<sup>+</sup>. The higher ionic strength suppressed and the lower enhanced the rate of superprecipitation respectively. 2. No effect of ouabain was found on the rate of superprecipitation. 3. Mitochondria depressed the rate of superpretipitation, and the depressed rate of superprecipitation by mitochondria was reversed by ouabain, and the degree of this reversal was almost identical in Na<sup>+</sup> and K<sup>+</sup> medium. 4. Ca<sup>++</sup> uptake of mitochondria was inhibited by ouabain in the presence of ATP and the degree of inhibition showed the dose-response manner in terms of concentration of ouabain. 5. In the absence of ATP, mitochondria took or the Ca<sup>++</sup> in initial period but released it later. Such uptake and release of Ca<sup>++</sup> was not influenced by ouabain. 6. It is suggested that intracellular calcium mobilization by ouabain through the action upon the mitochondria was due to inhibition on ATP-dependent Ca<sup>++</sup> uptake by this agent, not to the action upon so called binding.
人蔘, 桔梗, 및 遠志 Saponin에 對한 毒性比較 (第一報)
洪思岳,李容采,金濟勳,金暎洙,金東秀,李哲和,李恒振,韓大燮,宋雄奎,高桂珣 中央醫學社 1963 中央醫學 Vol.5 No.6
As a preliminary study on Panax ginseng, the saponin fraction of Panax ginseng, Platycodon grandiflorun and Polygala tenuifolia were extracted and purified to compare with toxicities in animals. Gypsophila saponin was used as the standard. Following were the results; 1) In fish the toxicities of saponins less intense from Ginseng and Platycodon were, while those of Polygala and Gypsophila were remarkable. 2) Hemolytic action of Ginseng saponin in defibrinized blood of cows, guinea pigs rabbits and rats was weak, which, however, was increased in order of Platycodi, Gypsophila and Polygala. 3) LP5n in mouse were; 275±52.0mg/kg. with Ginseng, 367-1-52.05mg/kg. with Paltycodi, 111.9±23.0mg/kg. with Gypsophila and 31.05±4.55mg/kg. with Polygala respectively.
Anthraquinone 誘導體를 含有한 2,3生藥의 潟下作用
洪思岳 中央醫學社 1961 中央醫學 Vol.1 No.8
In Polygonaceae family R'ieum undulatum L., Rumex japonicus Houttuyn and Reynoutria elliptica (kuidzumi) migo, the Anthraquinone amounts are determined quantitatively, and comparative pharmacological effects are obtained by the observation of several experimental animals such as albino mice, albino rats, rabbits and dogs. . Among Rheum undulatum L., Rumex Japonicus Houttuyn, and Reynoutria elliptica, Rheum. undulatum L. contained the large amount of anthraquinone, and next Rumex japonicus Houttuyn and the least Reynoutria elliptica. Reynoutria elliptica has greater toxicity than the others. The effect of cathartic action of these crude drugs are not proportional to anthraquinone content, The effect of cathartic action of Rheum undulatum L. on a given rabbits required large amount than the other animals, and its effect is prominent. But the effect of cathartic action on a given dog required the least amount and is prominent in the action of Rheum undulatum L.
홍사악,Hong, Sa-Ack 대한약리학회 1981 대한약리학잡지 Vol.17 No.2
The effects of Panax ginseng and Acanthopanax on egg production of hens are studied. The hens are fed with three dose levels of ethnaol extract of Panax ginseng and Acanthopanax for 24 months. The weight of each egg and number of egg production per month were compared between control group and treated group. The average weight of egg was not influenced by treatment of Panax ginseng and Acanthopanax. The number of egg production in control group was markedly decreased during cold season (from November to March). Panax ginseng and Acanthopanax markedly improve the egg production during cold season compared with control group.