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Healy, Kevin D.,Hodgson, Louis,Kim, Tai-Young,Shutes, Adam,Maddileti, Savitri,Juliano, Rudolph L.,Hahn, Klaus M.,Harden, T. Kendall,Bang, Yung-Jue,Der, Channing J. Wiley Subscription Services, Inc., A Wiley Company 2008 Molecular carcinogenesis Vol.47 No.5
<P>Expression of the tumor suppressor deleted in liver cancer-1 (DLC-1) is lost in non-small cell lung (NSCLC) and other human carcinomas, and ectopic DLC-1 expression dramatically reduces proliferation and tumorigenicity. DLC-1 is a multi-domain protein that includes a Rho GTPase activating protein (RhoGAP) domain which has been hypothesized to be the basis of its tumor suppressive actions. To address the importance of the RhoGAP function of DLC-1 in tumor suppression, we performed biochemical and biological studies evaluating DLC-1 in NSCLC. Full-length DLC-1 exhibited strong GAP activity for RhoA as well as RhoB and RhoC, but only very limited activity for Cdc42 in vitro. In contrast, the isolated RhoGAP domain showed 5- to 20-fold enhanced activity for RhoA, RhoB, RhoC, and Cdc42. DLC-1 protein expression was absent in six of nine NSCLC cell lines. Restoration of DLC-1 expression in DLC-1-deficient NSCLC cell lines reduced RhoA activity, and experiments with a RhoA biosensor demonstrated that DLC-1 dramatically reduces RhoA activity at the leading edge of cellular protrusions. Furthermore, DLC-1 expression in NSCLC cell lines impaired both anchorage-dependent and -independent growth, as well as invasion in vitro. Surprisingly, we found that the anti-tumor activity of DLC-1 was due to both RhoGAP-dependent and -independent activities. Unlike the rat homologue p122RhoGAP, DLC-1 was not capable of activating the phospholipid hydrolysis activity of phospholipase C-δ1. Combined, these studies provide information on the mechanism of DLC-1 function and regulation, and further support the role of DLC-1 tumor suppression in NSCLC. © 2007 Wiley-Liss, Inc.</P>
Autologous Microvascular Breast Reconstruction
Healy, Claragh,Ramakrishnan, Venkat Korean Society of Plastic and Reconstructive Surge 2013 Archives of Plastic Surgery Vol.40 No.1
Autologous microvascular breast reconstruction is widely accepted as a key component of breast cancer treatment. There are two basic donor sites; the anterior abdominal wall and the thigh/buttock region. Each of these regions provides for a number of flaps that are successfully utilised in breast reconstruction. Refinement of surgical technique and the drive towards minimising donor site morbidity whilst maximising flap vascularity in breast reconstruction has seen an evolution towards perforator based flap reconstructions, however myocutaneous flaps are still commonly practiced. We review herein the current methods of autologous microvascular breast reconstruction.
Autologous Microvascular Breast Reconstruction
Claragh Healy,Venkat Ramakrishnan 대한성형외과학회 2013 Archives of Plastic Surgery Vol.40 No.1
Autologous microvascular breast reconstruction is widely accepted as a key component of breast cancer treatment. There are two basic donor sites; the anterior abdominal wall and the thigh/buttock region. Each of these regions provides for a number of flaps that are successfully utilised in breast reconstruction. Refinement of surgical technique and the drive towards minimising donor site morbidity whilst maximising flap vascularity in breast reconstruction has seen an evolution towards perforator based flap reconstructions, however myocutaneous flaps are still commonly practiced. We review herein the current methods of autologous microvascular breast reconstruction.
Experience of ReCell in Skin Cancer Reconstruction
Onur Gilleard,Ciaran Healy,Nicholas Segaren 대한성형외과학회 2013 Archives of Plastic Surgery Vol.40 No.5
The ReCell system (Avita Medical) is a cell culture product that allows the immediate processing of a small split-thickness skin biopsy to produce a complete population of cells including keratinocytes, melanocytes, Langerhans cells and fibroblasts. This series is the first to highlight the reconstructive applications of ReCell following ablative skin cancer surgery. The ReCell system was utilized for three patients following skin cancer excision. In two cases, the cells were applied to forehead flap donor sites following nasal reconstruction. In one case, the cells were applied to the calvarial periosteum following wide local excision of a melanoma scar. Assessment of the treated area was performed using the patient and observer scar assessment scale after 1 year. The Patient and Observer Scar Assessment Scale (POSAS) scores for the 2 patients treated with ReCell following forehead flap surgery were 22 and 32. The score for the patient that underwent wide local excision of a melanoma scar was 45. The absence of a donor site, accelerated healing and the satisfactory aesthetic appearance of the mature scars in this series suggest that ReCell may play a useful role in reconstruction following skin cancer excision.
( Joo Yeon Jin ),( Melanie Healy ) 한국체육학회 2015 국제스포츠과학 학술대회 Vol.2015 No.1
Background/Purpose: Physical education (PE) is considered a primary vehicle that positively influences physical activity (PA) behavior of children and adolescents because early PA habits are more likely carried into adulthood (Erwin et al., 2013; Sallis et al., 2012). Thus, well physically educated youths may have stronger intentions to participate in PA than their counterparts who didn`t have quality PE. However, there have been no research efforts to investigate the influence of PE on the intention-PA relationship in youths. The purpose of this study was to examine if past PA behavior in high school PE moderates the relationship of current implementation intention (II) and PA levels among college students. Method: A total of 332 college students from a university in Midwest of the United States participated in this study. Participants` II and past PA in high school PE were assessed using paper questionnaires, and HJ-720IT pedometers (Omron healthcare, Bannockburn, IL) were used for 7 days to monitor participants` PA levels (i.e., step counts). Results: A multiple regression using PROCESS (a computational procedure for SPSS that implements moderation analysis) showed significant moderation effect of past PA behavior in high school PE (p<.05) on the relationship of II and PA levels in college students, after accounting for II and PA behavior in high school PE. When divided to three groups, II significantly predicted PA only in participants with low (p<.001) or medium (p<.01) levels of PA participation in PE, but not high group. Conclusions: Study findings indicate that school PE is imperative to promote youths` PA, but intentional behavioral change may not be adequate to increase PA levels for those who were very active in high school PE. Additional strategies, such as reminders, self-monitoring, and awareness of cues would be necessary for this subgroup.