http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Harburg, Daniel V. (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Bioresorbable silicon electronic sensors for the brain
Kang, Seung-Kyun,Murphy, Rory K. J.,Hwang, Suk-Won,Lee, Seung Min,Harburg, Daniel V.,Krueger, Neil A.,Shin, Jiho,Gamble, Paul,Cheng, Huanyu,Yu, Sooyoun,Liu, Zhuangjian,McCall, Jordan G.,Stephen, Manu Nature Publishing Group, a division of Macmillan P 2016 Nature Vol.530 No.7588
<P>Many procedures in modern clinical medicine rely on the use of electronic implants in treating conditions that range from acute coronary events to traumatic injury(1,2). However, standard permanent electronic hardware acts as a nidus for infection: bacteria form biofilms along percutaneous wires, or seed haematogenously, with the potential to migrate within the body and to provoke immune-mediated pathological tissue reactions(3,4). The associated surgical retrieval procedures, meanwhile, subject patients to the distress associated with re-operation and expose them to additional complications(5-8). Here, we report materials, device architectures, integration strategies, and in vivo demonstrations in rats of implantable, multifunctional silicon sensors for the brain, for which all of the constituent materials naturally resorb via hydrolysis and/or metabolic action(9-12), eliminating the need for extraction. Continuous monitoring of intracranial pressure and temperature illustrates functionality essential to the treatment of traumatic brain injury(2,13); the measurement performance of our resorbable devices compares favourably with that of non-resorbable clinical standards. In our experiments, insulated percutaneous wires connect to an externally mounted, miniaturized wireless potentiostat for data transmission. In a separate set-up, we connect a sensor to an implanted (but only partially resorbable) data-communication system, proving the principle that there is no need for any percutaneous wiring. The devices can be adapted to sense fluid flow, motion, pH or thermal characteristics, in formats that are compatible with the body's abdomen and extremities, as well as the deep brain, suggesting that the sensors might meet many needs in clinical medicine.</P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
