http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jian Wang,Qiong Niu,Ning Shi,Chengxia Liu,Haifeng Lian,Jiancheng Li,Kun Li,K. Li 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.3
Drug resistance remains to be one of the major challenges in clinical treatment of gastric cancer (GC). Accumulating evidences have highlighted the involvement of long non-coding RNA (lncRNA) in carcinogenesis, chemoresistance, and metastasis. NEAT1, a recently identified lncRNA, was identified as an oncogene to regulate carcinogenesis. This present study aimed to investigate the role of NEAT1 in the drug resistance in GC. Our study found that NEAT1 expression was significantly upregulated in relapsed GC patients and cisplatin (CDDP)-resistant cell lines compared with primary GC patients and parental GC cell lines. NEAT1 upregulation was largely companied with the induction of P-gp. Overexpression of NEAT1 significantly increased the expression of several drug-resistance proteins, thereby compromising the sensitivity of GC cells to CDDP. In contrast, NEAT1 knockdown by RNAi did the opposite. Therefore, lncRNA NEAT1 is an important modulator for drug resistance of GC via promoting the expression of P-gp and other associated proteins.