http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Haemmerle, Monika (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Role of ADP receptors on platelets in the growth of ovarian cancer
Cho, Min Soon,Noh, Kyunghee,Haemmerle, Monika,Li, Dan,Park, Hyun,Hu, Qianghua,Hisamatsu, Takeshi,Mitamura, Takashi,Mak, Sze Ling Celia,Kunapuli, Satya,Ma, Qing,Sood, Anil K.,Afshar-Kharghan, Vahid American Society of Hematology 2017 Blood Vol.130 No.10
<P>We investigated the effect of platelets on ovarian cancer and the role of adenosine diphosphate (ADP) receptors (P2Y12 and P2Y1) on platelets in the growth of primary ovarian cancer tumors. We showed that in murine models of ovarian cancer, a P2Y12 inhibitor (ticagrelor) reduced tumor growth by 60% compared with aspirin and by 75% compared with placebo. In P2Y12(-/-) mice, the growth of syngeneic ovarian cancer tumors was reduced by >85% compared with wild-type (WT) mice. In contrast, there was no difference in tumor growth between P2Y1(-/-) and WT mice. Reconstitution of hematopoiesis in irradiated P2Y12(-/-) mice by hematopoietic progenitor cells from WT mice (WT -> P2Y12(-/-)) restored tumor growth in P2Y12(-/-) mice. Finally, knockdown of ecto-apyrase (CD39) on ovarian cancer cells increased tumor growth in tumor-bearing mice. Although in the absence of platelets, ADP, the P2Y12 inhibitor, recombinant apyrase, or knockdown of CD39 did not affect cancer cell proliferation, in the presence of platelets, the P2Y12 inhibitor and recombinant apyrase reduced and knockdown of CD39 increased platelet-enhanced cancer cell proliferation. These results suggest that P2Y12 on platelets and ADP concentration at the interface between cancer cells and platelets affect the growth of primary ovarian cancer tumors in mice. If additional studies in mice and in pilot human trials confirm our results, inhibition of P2Y12 might be a new therapeutic option that can be used in adjuvant to the traditional surgery and chemotherapy in patients with ovarian cancer.</P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
