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제3요추횡돌기증후군의 생체역학적, 해부생리학적, 신경화학적관점의 고찰과 의의
Kim Jaeseok,Gwon Goeun,Kim Hongik,Lee Joohyun,Choi Sungwoon 대한침도의학회 2023 대한침도의학회지 Vol.7 No.2
Background: The third lumbar transverse process syndrome refers to local tenderness and other symptoms accompanied by pain in the lower back, hips, and legs due to chronic damage to muscles, fascia, and other soft tissues attached to third lumbar transverse pro- cess. The third lumbar transverse process syndrome was proposed in acupotomology, and the third lumbar transverse process syndrome accounts for a large part of low back pain. We investigated the importance of third lumbar transverse process syndrome from view of biomechanical, anatomical physiology, and neurochemical. Methods: We searched and organized of literature on third lumbar process syndrome through pubmed, google scholar & CNKI. Results: The effects of acuptomy treatment were examined from three perspectives. From a biomechanics point of view, Acupotomy treatment relieves abnormal tension in soft tis- sues and stimulates recovery. From anatomical physiology point of view, acupotomy treat- ment into fascia can improve blood flow and normalize wrinkles and elasticity to restore the normal function of the fascia. From a neurochemistry point of view, acupotomy treat- ment reduces the high concentration of NO produced by iNOS and promotes the repair of soft tissue, also reduces chronic pain by lowering TNF- α and IL-1β serum levels. Conclusion: The finding of this paper will help to provide understanding of biomechanical, anatomical, and neurochemical perspectives of the third lumbar transverse process Syn- drome and It’s significance.
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Lee, Seung Ho,Piao, Huiyan,Cho, Yong Chan,Kim, Se-Na,Choi, Goeun,Kim, Cho Rim,Ji, Han Bi,Park, Chun Gwon,Lee, Cheol,Shin, Chong In,Koh, Won-Gun,Choy, Young Bin,Choy, Jin-Ho National Academy of Sciences 2019 Proceedings of the National Academy of Sciences Vol.116 No.24
<P><B>Significance</B></P><P>We propose an implantable multireservoir device equipped with stimulus-responsive membrane to allow for on-demand and pulsatile drug delivery. The stimulus-responsive membrane is made of a thermosensitive polymer, POSS(MEO<SUB>2</SUB>MA-co-OEGMA), and photothermal nanoparticles of reduced graphene oxide. Each of the drug reservoirs is filled with the same amount of human growth hormone and capped with the stimulus-responsive membrane. Therefore, when implanted in living animals, the device herein can deliver drug reproducibly by rupturing a stimulus-responsive membrane only at the times of near-infrared irradiation applied from the outside body without showing complications.</P><P>Implantable devices for on-demand and pulsatile drug delivery have attracted considerable attention; however, many devices in clinical use are embedded with the electronic units and battery inside, hence making them large and heavy for implantation. Therefore, we propose an implantable device with multiple drug reservoirs capped with a stimulus-responsive membrane (SRM) for on-demand and pulsatile drug delivery. The SRM is made of thermosensitive POSS(MEO<SUB>2</SUB>MA-co-OEGMA) and photothermal nanoparticles of reduced graphene oxide (rGO), and each of the drug reservoirs is filled with the same amount of human growth hormone (hGH). Therefore, with noninvasive near-infrared (NIR) irradiation from the outside skin, the rGO nanoparticles generate heat to rupture the SRM in the implanted device, which can open a single selected drug reservoir to release hGH. Therefore, the device herein is shown to release hGH reproducibly only at the times of NIR irradiation without drug leakage during no irradiation. When implanted in rats with growth hormone deficiency and irradiated with an NIR light from the outside skin, the device exhibits profiles of hGH and IGF1 plasma concentrations, as well as body weight change, similar to those in animals treated with conventional s.c. hGH injections.</P>
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