Prediction of exploration targets based on integrated analyses of source rock and simulated hydrocarbon migration direction: a case study from the gentle slope of Shulu Sag, Bohai Bay Basin, northern China

Changqing Ren,Fugui He,Xianzhi Gao,Dongsheng Wu,Wenli Yao,Jianzhang Tian,Huiping Guo,Yuanxin Huang,Li Wang,Han Feng,Junwei Li 한국지질과학협의회 2019 Geosciences Journal Vol.23 No.6

The Shulu Sag which is a rifted sag with NNE trend is located in the south of Jizhong Depression, Bohai Bay Basin, northern China. The gentle slope and three troughs are situated in the west and east of the sag, respectively. Both of the lower part of Shasan Member (Es3x) and the lower part of Shayi Member (Es1x) act as source rocks in this sag. Researches on the type, quantity, quality and thermal maturity of the respective organic matter have been conducted using Rock-Eval pyrolysis data. Type II is the dominant kerogen in Es1x of all troughs. However, Type II1 and III is the dominant kerogen in Es3x of Middle-Southern and Northern trough, respectively. TOC (total organic carbon) and pyrolysis S2 (hydrocarbon) values suggest that the Es1x source rocks in Middle-Southern and Northern trough are fair to good and poor to fair generative potential of hydrocarbon, separately. The Es3x source rocks in Middle-Southern and Northern trough possess fair to excellent and poor to fair generative potential of hydrocarbon, individually. Tmax (pyrolysis temperature at maximum S2) values indicate that most of Es3x samples are thermally mature, but all Es1x samples are thermally immature. Under large scale condition, the hydrocarbon secondary migration in the upper part of Shasan Member (Es3s), Shaer Member (Es2) and the upper part of Shayi Member (Es1s) have been simulated using fluid potential model with Arcgis 9.3 software. The simulation results reveal the direction of hydrocarbon secondary migration and the distribution of hydrocarbon migration-accumulation units (HMAUS), and also suggest that the hydrocarbon migration direction is obviously controlled by nose-like structure belts where most of hydrocarbons accumulate. That shows high reliability because they are consistent with the hydrocarbon exploration result in this area. On the basis of integrated analyses of source rocks and hydrocarbon migration direction, the following five areas in the gentle slope are identified to be the preferred hydrocarbon accumulation area: Taijiazhuang area, northern and southern Xicaogu area, as well as northern and southern Leijiazhuang area. It is considerably helpful to reduce the risk in hydrocarbon exploration of Shulu Sag.

Hierarchical Control of Yaw Stability and Energy Efficiency for Distributed Drive Electric Vehicles

Jing Changqing,Shu Hongyu,Song Yitong,Guo Cheng 한국자동차공학회 2021 International journal of automotive technology Vol.22 No.5

A dual-layer energy-efficient control strategy is proposed for distributed drive electric vehicles to reduce energy consumption during cornering maneuvers and improve vehicle stability. The hierarchical control strategy consists of two energy-saving schemes. The first-layer energy-efficient scheme combines an active front steering (AFS) system and direct yaw moment control (DYC) to improve vehicle stability and reduce total energy consumption. An extended Kalman filter observer is proposed to estimate lateral forces and side-slip angle. The second-layer energy-efficient scheme adopts a multiobjective driving/braking torque allocation algorithm to achieve minimum energy consumption while maintaining vehicle stability. A friction ellipse constraint and an actuator constraint are considered. Furthermore, the effect of the actuator restraint on the vehicle’s yaw stability in a high-speed cornering maneuver is studied. Finally, the proposed control strategy is evaluated in MATLAB and the CarSim platform. The results demonstrate that the actuator constraint has a great influence on vehicle stability during high-speed cornering maneuvers. In addition, compared with a conventional control strategy, the dual-layer energy-efficient control strategy can reduce energy consumption by 29.5 % and 28.8 % for the dual lane change maneuver and high-speed snake steering maneuver, respectively. The proposed control strategy can effectively enhance the vehicle’s handing performance during high-speed cornering maneuvers.

Design and analysis of an origami-inspired deployable grasping manipulator

Xin Guo,Changqing Gao,Hailin Huang,Bing Li,Yingxue Yao,Guanglu Jia 한국생산제조학회 2018 한국생산제조시스템학회 학술발표대회 논문집 Vol.2018 No.10

HYDROGEN PRODUCTION FROM CHICKEN MANURE BY SUPERCRITICAL WATER GASIFICATION IN A FLUIDIZED BED REACTOR

Wen Cao,Changqing Cao,Liejin Guo,Hui Jin,Xiangdong Yao 한국신재생에너지학회 2015 AFORE Vol.2015 No.11

Clinical Study of Acupotomy Treatment for Tarsal Tunnel Syndrome

Fu Xinyi,Lee Mira,Guo Changqing 대한침구의학회 2020 대한침구의학회지 Vol.37 No.2

Background: Compared with conventional closed therapy, acupotomy has the advantages of lower cost, convenient application, and better single and long-term effects. The aim of this study was to explore the clinical effect of acupotomy in the treatment of Tarsal Tunnel syndrome.Methods: There were 80 patients enrolled into the study who were randomly assigned to either the acupotomy or closed therapy group, with 40 patients in each group. The acupotomy group was treated once every 6 days, on 3 occasions for the duration of treatment, and the closed therapy group was treated twice a week, for 3 weeks as the course of treatment. The effects of treatment were analyzed and evaluated according to the standard of curative effect.Results: The “cure rate” of the number of patients in the acupotomy group whose symptoms had completely disappeared (13 patient out of 39) was higher than the closed therapy group (1 patient out of 39), and this difference was significant (<i>p</i> < 0.01). The number of patients in the acupotomy group who did not benefit from the therapy (5 patients) was significantly lower than the closed therapy group (15 patients; <i>p</i> < 0.05). The total number of patients in the acupotomy group who benefitted from the therapy (34 patients) resulted in an effective rate of 87.18%, which was higher than the closed therapy group (24 patients; 61.53%). The difference was statistically significant (<i>p</i> < 0.05).<br/>Conclusion: Acupotomy is effective in the treatment of Tarsal Tunnel syndrome, was superior to traditional closed therapy, and is worthy of clinical application.

Comparison of overfed Xupu and Landes geese in performance, fatty acid composition, enzymes and gene expression related to lipid metabolism

Liu Xu,Li Peng,He Changqing,Qu Xiangyong,Guo Songchang 아세아·태평양축산학회 2020 Animal Bioscience Vol.33 No.12

Objective: The aim of this study was to compare overfeeding performance, fatty acid composition, blood chemistry, enzymes and genes expression overfed Xupu and Landes geese. Methods: Sixty male Xupu geese (80 d) and Landes geese (80 d) were selected. After a period of one-week of pre-overfeeding, Xupu and Landes geese were overfed three meals of 550 and 350 g/d, respectively, of a high-carbohydrate diet in the first week of the overfeeding period. The next week, geese were given four meals of 1,200 and 850 g/d, respectively, over 8 to 14 d. Finally, geese were given five meals of 1,600 and 1,350 g/d, respectively, for the last two weeks. Results: After overfeeding for 28 d: Compared with Landes geese, Xupu geese liver weight and liver-to-body weight ratio decreased (p<0.05), while final weight, slaughter weight, total weight gain, abdominal fat weight, and feed-to-liver weight ratio increased (p<0.05). The levels of elaidic acid (C18:1t9), oleic acid (C18:1n-9), eicosenoic acid, and arachidonic acid in the liver of Xupu geese significantly increased (p<0.05), and the levels of myristic acid and stearic acid significantly decreased (p<0.05), while methyleicosanoate acid significantly increased (p<0.05). Xupu geese had higher plasma concentrations of triglyceride and very low density lipoprotein cholesterol (p<0.05), and decreased activities of alanine aminotransferase, aspartate aminotransferase, and lipase (LPS) (p<0.05). Landes geese had higher LPS activity (p<0.05), but lower cholinesterase activity (p<0.05) when compared with Xupu geese. The mRNA expression levels of fatty acid dehydrogenase (FADS) gene, elongase of long-chain fatty acid 1 (ELOVL1) gene, ELOVL5, and acyl-Co A: cholesterol acyltransferase 2 (ACAT2) gene were significantly upregulated (p<0.05) in Landes goose when compared with Xupu geese. Conclusion: This study demonstrates that the liver production performance of Landes geese was better than that of Xupu geese to some extent, which may be closely related to LPS activity, as well as the expression of FADS, ELOVL1, ELOVL5, and ACAT2.

Assessment of the Cytotoxic and Apoptotic Effects of Chaetominine in a Human Leukemia Cell Line

Jing-Yun Yao,Ruihua Jiao,Changqing Liu,Yupeng Zhang,Wan-Guo Yu,Yan-Hua Lu,Renxiang Tan 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.2

Chaetominine is a quinazoline alkaloid originating from the endophytic fungus Aspergillus fumigatus CY018. In this study, we showed evidence that chaetominine has cytotoxic and apoptotic effects on human leukemia K562 cells and investigated the pathway involved in chaetominine-induced apoptosis in detail. Chaetominine inhibited K562 cell growth, with an IC50 value of 35 nM, but showed little inhibitory effect on the growth of human peripheral blood mononuclear cells. The high apoptosis rates, morphological apoptotic features, and DNA fragmentation caused by chaetominine indicated that the cytotoxicity was partially caused by its pro-apoptotic effect. Under chaetominine treatment, the Bax/Bcl-2 ratio was upregulated (from 0.3 to 8), which was followed by a decrease in mitochondrial membrane potential, release of cytochrome c from mitochondria into the cytosol, and stimulation of Apaf-1. Furthermore, activation of caspase-9 and caspase-3, which are the main executers of the apoptotic process, was observed. These results demonstrated that chaetominine induced cell apoptosis via the mitochondrial pathway. Chaetominine inhibited K562 cell growth and induced apoptotic cell death through the intrinsic pathway, which suggests that chaetominine might be a promising therapeutic for leukemia.

Acupotomy for Lumbar disc herniation

Chen Xilin,Fu Xinyi,Luo Zhichao,Xin Wenshan,Wang Quangui,Lee Mira,Guo Changqing 대한침구의학회 2020 대한침구의학회지 Vol.37 No.3

Background: The aim of this study was to examine whether the effects of acupotomy therapy were beneficial for the treatment of protrusion of lumbar intervertebral disc. Methods: The number of patients (n = 80) were equally assigned into treatment group and control group. Treatment group was given acupotomy therapy twice a week, and control group was given acupuncture 3 times a week, for 4 weeks. The beneficial effect and changes in score of the Japan Orthopedic Association (JOA) for low back pain were observed. Results: Among 40 cases in the treatment group, there were 25 (62.5%) with an excellent effect, 13 (32.5%) with good effect, 1 (2.5%) with a medium effect and 1 (2.5%) with poor effect, with the total experiencing an excellent/good effect of 95.0%. Among 40 cases in the control group, there were 11 (27.5%) with an excellent effect, 17 (42.5%) with good effect, 10 (25.0%) with a medium effect, and 2 (5.0%) with poor effect, with an excellent/good rate of 70.0%. The result of the rank sum test showed Z = -4.923, p < 0.05 in the comparison, indicating a significantly better outcome following acupotomy compared with acupuncture. JOA scores increased in both groups after treatment (p < 0.05), which was more significant in the acupotomy treatment group (p < 0.05). Conclusion: Acupotomy therapy has a beneficial effect on protrusion of lumbar intervertebral disc.

Sterically hindered amine-functionalized MCM-41 composite for efficient carbon dioxide capture

Fei Gao,Cailin Ji,Shougui Wang,Weiwen Wang,Jipeng Dong,Changqing Guo,Yuwen Gao,Guanghui Chen 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.8

A new adsorbent based on sterically hindered amine for efficient CO2 capture was prepared. Mesoporoussilicon MCM-41 was modified by sterically hindered amine AMPD (2-amino-2-methyl-1,3-propanediol) in differentAMPD loadings by a facile solid-state self-assembly approach. The physicochemical properties of the MCM-41@AMPDcomposites were analyzed using XRD, BET, FT-IR and SEM, and the composites were investigated for the CO2 captureperformance, including CO2 capture capacity, adsorption selectivity and cycling stability. Characterization analysesshowed that the AMPD active components were successfully incorporated and well dispersed into the mesoporous siliconMCM-41 surfaces. Adsorption results suggest that the modification by the active ingredient AMPD can significantlyimprove the CO2 capture performance. The MCM-41@AMPD material with an AMPD loading of 7mmol∙g1MCM-41 support exhibits a good CO2 adsorption capacity and CO2 adsorption selectivity, and shows excellent cyclingstability. Furthermore, the isosteric heat of CO2 adsorption on the MCM-41@AMPD-7 material was evaluated by theClausius-Clapeyron equation, and the value was 34-78 kJ∙mol1.

Glucocorticoid-induced expansion of classical monocytes contributes to bone loss

Liu Pei,Gao Youshui,Luo Pengbo,Yu Hongping,Guo Shang,Liu Fuyun,Gao Junjie,Xu Jianzhong,Wang Shengdian,Zhang Changqing 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Classical monocytes are commonly involved in the innate inflammatory response and are the progenitors of osteoclasts. Excess endogenous glucocorticoids (GCs) can increase the levels of classical monocytes in blood and bone marrow. The role of this cell population in high-dose exogenous GC-induced osteoporosis (GIOP) remains to be elucidated. In this study, GIOP was established in rats and mice by daily methylprednisolone injection, and monocyte subsets were analyzed by flow cytometry. We demonstrated that classical monocytes accumulate in bone marrow during GIOP. Similarly, the monocyte proportion among bone marrow nucleated cells was also increased in patients with steroid treatment history. We sorted classical monocytes and analyzed their transcriptional profile in response to GCs by RNA sequencing. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed that classical monocytes isolated from GC-treated rats exhibited osteoclast differentiation potential. Deletion of classical monocytes by clodronate liposome treatment prevented GIOP via inhibition of osteoclastogenesis and restoration of CD31HiendomucinHi vessels. Regarding the molecular mechanism, classical monocytes express high levels of glucocorticoid receptors. In vitro treatment with GCs increased both the percentage and absolute number of monocytes and promoted their proliferation. In summary, classical monocytes mediated GC-induced bone loss and are a potential target for therapeutic intervention in GIOP treatment.