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- 저자 : Guimei Pang (검색결과 2 건)
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Gallic Acid Ameliorates Cognitive Impairment Caused by Sleep Deprivation through Antioxidant Effect
Pang Xiaogang,Xu Yifan,Xie Shuoxin,Zhang Tianshu,Cong Lin,Qi Yuchen,Liu Lubing,Li Qingjun,Mo Mei,Wang Guimei,Du Xiuwei,Shen Hui,Li Yuanyuan 한국뇌신경과학회 2023 Experimental Neurobiology Vol.32 No.4
Sleep deprivation (SD) has a profound impact on the central nervous system, resulting in an array of mood disorders, including depression and anxiety. Despite this, the dynamic alterations in neuronal activity during sleep deprivation have not been extensively investigated. While some researchers propose that sleep deprivation diminishes neuronal activity, thereby leading to depression. Others argue that short-term sleep deprivation enhances neuronal activity and dendritic spine density, potentially yielding antidepressant effects. In this study, a two-photon microscope was utilized to examine the calcium transients of anterior cingulate cortex (ACC) neurons in awake SD mice in vivo at 24-hour intervals. It was observed that SD reduced the frequency and amplitude of Ca2+ transients while increasing the proportions of inactive neurons. Following the cessation of sleep deprivation, neuronal calcium transients demonstrated a gradual recovery. Moreover, whole-cell patch-clamp recordings revealed a significant decrease in the frequency of spontaneous excitatory post-synaptic current (sEPSC) after SD. The investigation also assessed several oxidative stress parameters, finding that sleep deprivation substantially elevated the level of malondialdehyde (MDA), while simultaneously decreasing the expression of Nuclear Factor erythroid 2-Related Factor 2 (Nrf2) and activities of Superoxide dismutase (SOD) in the ACC. Importantly, the administration of gallic acid (GA) notably mitigated the decline of calcium transients in ACC neurons. GA was also shown to alleviate oxidative stress in the brain and improve cognitive impairment caused by sleep deprivation. These findings indicate that the calcium transients of ACC neurons experience a continuous decline during sleep deprivation, a process that is reversible. GA may serve as a potential candidate agent for the prevention and treatment of cognitive impairment induced by sleep deprivation.
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Load Allocation Strategy for Command and Control Networks based on Interdependence Strength
Bo Chen,Guimei Pang,Zhengtao Xiang,Hang Tao,Yufeng Chen 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.9
Command and control networks(C2N) exhibit evident multi-network interdependencies owing to their complex hierarchical associations, interleaved communication links, and dynamic network changes. However, the existing command and control networks do not consider the effects of dependent nodes on the load distribution. Thus, we proposed a command and control networks load allocation strategy based on interdependence strength. First, a new measure of interdependence strength was proposed based on the edge betweenness, which was followed by proposing the inter-layer load allocation strategy based on the interdependence strength. Eventually, the simulation experiments of the aforementioned strategy were designed to analyze the network invulnerability with different initial load capacity parameters, allocation model parameters, and allocation strategies. The simulation indicates that the strategy proposed in this study improved the node survival rate of the interdependent command and control networks model and successfully prevented cascade failures.
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