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Age-related differences in the pathogenesis of chronic rhinosinusitis
Cho, S.H.,Hong, S.J.,Han, B.,Lee, S.H.,Suh, L.,Norton, J.,Lin, D.,Conley, D.B.,Chandra, R.,Kern, R.C.,Tan, B.K.,Kato, A.,Peters, A.,Grammer, L.C.,Schleimer, R.P. Mosby 2012 The Journal of allergy and clinical immunology Vol.129 No.3
Although chronic rhinosinusitis (CRS) significantly affects the quality of life of elderly people, the inflammatory mechanisms of chronic rhinosinusitis in the elderly have not been well studied. This study demonstrates that despite the higher severity of CRS observed in elderly patients, they had lower eosinophilic cationic protein compared to non-elderly CRS patients. In addition, S100A8/9 was significantly decreased in CRS with aging process, suggesting that epithelial barrier dysfunction may continue to play an important role in the pathogenesis of CRS while eosinophilic inflammation may subside with age.