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Anti-apoptotic and anti-inflammatory activity of Gentiana lutea root extract
Teresa Cafaro,Veronica Carnicelli,Giovanni Caprioli,Filippo Maggi,Giuseppe Celenza,Mariagrazia Perilli,Argante Bozzi,Gianfranco Amicosante,Fabrizia Brisdelli 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.4
Gentiana lutea roots have been widely used in the traditional medicine, especially for their stomachic properties. In this study, the effect of G. lutea root methanol extract on SH-SY5Y cell survival and on anti-proliferative activity of pro-apoptotic agents was evaluated. In neuroblastoma cell line SH-SY5Y, the extract did not exhibit any cytotoxic activity, but protected cells from vinblastine-induced apoptosis. In the combined treatment with 200 μg/ml extract plus 0.1 μM vinblastine, extract significantly increased cell survival, reduced the percentage of apoptotic cells and decreased caspase-3 activity if compared with the vinblastine alone treatment. The anti-apoptotic activity of the extract was associated to the down-regulation of Sirt-1 protein and to the increase of anti-apoptotic Bcl-2 protein expression and intracellular GSH levels. Since the apoptosis modulation was evidenced on a neuroblastoma cell line, G. lutea extract could have a promising potential as a neuroprotective agent. Moreover, G. lutea root extract exhibited anti-inflammatory activity, since it inhibited LPS-induced expression of TNF-α in macrophage RAW264.7 cells.
Correction to: Anti-apoptotic and anti-inflammatory activity of Gentiana lutea root extract
Teresa Cafaro,Veronica Carnicelli,Giovanni Caprioli,Filippo Maggi,Giuseppe Celenza,Mariagrazia Perilli,Argante Bozzi,Gianfranco Amicosante,Fabrizia Brisdelli 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.3