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Endocrine-specific NIR fluorophores for adrenal gland targeting
Ashitate, Yoshitomo,Levitz, Andrew,Park, Min Ho,Hyun, Hoon,Venugopal, Vivek,Park, GwangLi,El Fakhri, Georges,Henary, Maged,Gioux, Sylvain,Frangioni, John V.,Choi, Hak Soo The Royal Society of Chemistry 2016 Chemical communications Vol.52 No.67
<P>The adrenal glands (AGs) are relatively small yet require definitive identification during their resection, or more commonly their avoidance. To enable image-guided surgery involving the AGs, we have developed novel near-infrared (NIR) fluorophores that target the AGs after a single intravenous injection, which provided dual-NIR image-guided resection or avoidance of the AGs during both open and minimally-invasive surgery.</P>