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EFFECT OF PURIFIED ALGINATE MICROCAPSULES ON THE REGENERATION OF CHONDROCYTES
Hwang, Ji Hye,Kim, On You,Kim, A Ram,Bae, Ji Yeon,Jeong, Su Mi,Shim, Jung Bo,Yoon, Kun Ho,Lee, Dongwon,Khang, Gilson National Taiwan University 2012 Biomedical engineering Vol.24 No.3
<P> Adult articular cartilage tissue has poor capability of self-repair. Therefore, a variety of tissue engineering approaches are motivated by the clinical need for articular repair. Alginate has been used as a biomaterial for cartilage regeneration. The alginate is a natural polymer that is extracted from seaweeds and purification. However, the main drawback is the immune rejection in vivo. To overcome this problem, we have developed the biocompability of alginate using modified Korbutt method. After alginate was purified, purified alginate microcapsules were used in cartilage regeneration. Chondrocytes were seeded in purified and nonpurified alginate microcapsules, and then cell viability, proliferation and phenotype were analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assay. Reverse transcriptase-polymerase chain reaction (RT-PCR) was conducted to confirm mRNA expression on collagen type I and collagen type II for chondrocytes phenotype. Hematoxylin and eosin (H&E) and Safranin-O histological staining showed tissue growth at the interface during the first 10 days. In this study, chondrocytes in purified alginate microcapsules had higher cell viability, proliferation and more phenotype expression than those in nonpurified alginate microcapsules. The results suggest that the purified alginate microcapsule is useful for cartilage regeneration. </P>
Cho, Sujin,Hwang, On,Lee, Iljea,Lee, Gayoung,Yoo, Donghyuck,Khang, Gilson,Kang, Peter M.,Lee, Dongwon WILEY‐VCH Verlag 2012 Advanced Functional Materials Vol.22 No.19
<P><B>Abstract</B></P><P>Hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>) is one of essential oxygen metabolites in living organisms, but is generated in large amounts during inflammatory responses. Therefore, H<SUB>2</SUB>O<SUB>2</SUB> has great potential as diagnostic and therapeutic markers of several inflammatory and life‐threatening diseases. Here, chemiluminescent and antioxidant micelles are reported as novel theranostic agents for H<SUB>2</SUB>O<SUB>2</SUB>‐associated inflammatory diseases. The chemiluminescent micelles composed of amphiphilic block copolymer Pluronic F‐127, hydroxybenzyl alcohol‐incorporated copolyoxalate (HPOX) and fluorescent dyes perform peroxalate chemiluminescence reactions to detect H<SUB>2</SUB>O<SUB>2</SUB> as low as 100 nM and image H<SUB>2</SUB>O<SUB>2</SUB> generated in inflamed mouse ankles. The micelles encapsulating HPOX reduce the generation of reactive oxygen species in lipopolysaccharide (LPS)‐activated macrophages by scavenging overproduced H<SUB>2</SUB>O<SUB>2</SUB> and releasing antioxidant hydroxybenzyl alcohol (HBA). They also exert inhibitory effects on H<SUB>2</SUB>O<SUB>2</SUB>‐induced apoptosis. HPOX‐based chemiluminescent and antioxidant micelles have great potential as a theranostic agent for H<SUB>2</SUB>O<SUB>2</SUB>‐associated inflammatory diseases.</P>
Cho, Sujin,Hwang, On,Lee, Iljea,Lee, Gayoung,Yoo, Donghyuck,Khang, Gilson,Kang, Peter M.,Lee, Dongwon WILEY‐VCH Verlag 2012 Advanced Functional Materials Vol.22 No.19
<P>Chemiluminescent micelles contain polyoxalate and fluorophore in the core and are capable of performing a peroxalate chemiluminescence reaction with hydrogen peroxide. Hydrogen peroxide is generated in large amounts during inflammatory responses. As reported by Dongwon Lee and co‐workers on page 4038, diffusion of hydrogen peroxide into the interior of chemiluminescent micelles initiates the peroxalate chemiluminescence reaction and subsequent light emission, allowing the detection of inflammatory diseases. </P>
대청호의 일차생산과 가두리양어장 및 유역으로부터의 유기물부하량
황길순,김동섭,허우명,김범철 ( Gilson Hwang,Dong Sup Kim,Woo Myung Heo,Bomchul Kim ) 한국하천호수학회 1994 생태와 환경 Vol.27 No.4
The total input of organic carbon into Lake Daechung was determined by measuring the primary production of phytoplankton, the organic carbon loading from the watershed, and the fecal discharge from netcage fishfarming. Primary productivity was estimated by photosynthesis-irradiance (P-I) model method using C-14 uptake. The loading from the watershed and output of organic carbon were determined by measuring COD of four main inlet streams and outflowing water. The discharge from fishfarms was estimated from the amount of fishfeed applied annually and the rate of COD discharge per unit weight of fishfeed. Daily productivity at the dam site and the fishfarm site was 200-900 and 200-2500mgC/m^2/day, respectively, falling in the range of meso-eutrophic lakes. The assimilation number at the fishfarm site was higher than that of the dam site, which seems to be the results of large nutrients discharge from the fishfarms. The organic carbon loading from the watershed, primary production, discharge from fishfarms were determined to be 4702, 11666, 794tC/yr, respectively. Most of organic carbon(68%) was contributed by autochthonous primary production of phytoplankton. Therefore, BOD removal of sewage in the watershed can not improve water quality of this lake, and phosphorus removal and subsequent phytoplankton reduction should be the major target to control for better water quality.