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      • KCI등재

        An Ellipse-Shaped Leaky-Wave Antenna Array for X-Band Aerial Landing System

        Basir Shahid,Sarfraz Mubashar,Ghauri Sajjad A.,Mohammad Nooh Bany 한국전자파학회 2022 Journal of Electromagnetic Engineering and Science Vol.22 No.3

        In this paper, an antenna array for the X-band aerial landing system has been proposed. The proposed antenna is an ellipse-shaped leakywave array radiating in slow mode wave and has a scanning range of 75° for different inter-element spacing. Four antenna arrays were designed: two with 60 elements and two with 30 elements each, all operating from 9.3 GHz to 12.3 GHz providing a gain of 30 dBi and 20 dBi, respectively. To verify the performance, a 15-element sub-array having an overall size of 210 mm × 30 mm and achieving a total gain of 17 dBi was fabricated and tested. The proposed sub-array was fabricated using Rogers Duroid5880 (<i>εr</i> = 2.2 and h = 1.575 mm). It has been shown through comparison of radiation patterns that measured and simulation results are in good agreement.

      • Clinical Profile, Treatment and Survival Outcome of Testicular Tumors: A Pakistani Perspective

        Bhatti, Abu Bakar Hafeez,Ahmed, Irfan,Ghauri, Rashid Khan,Saeed, Qamar,Mir, Khurram Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

        Background: Testicular cancer management is considered a marvel of modern science with excellent treatment results. Pakistan has a distinct ethnic variation and geographic distribution but data regarding clinical presentation of testicular tumors and their management is under reported. The objective of this study was to determine clinical profile, treatment modalities and survival outcome of testicular tumors in the Pakistani population. Materials and Methods: A retrospective review of patients who received treatment for testicular cancer at Shaukat Khanum Cancer Hospital from January 2009 to December 2012 was performed. Patient demographics, clinical features at presentation and treatment modalities were assessed. For categorical variables chi square test was used. Survival was calculated using Kaplan Meier survival curves and Log rank test was employed to determine significance. Results: The most common tumor was mixed germ cell tumor in 49% patients. For all tumor variants except seminoma, stage III was the most common clinical stage at presentation. Majority of patients with non seminomatous germ cell tumors presented in the15-30 year age group as compared to seminoma which was most prevalent in the 30-40 year age group. Orchiectomy followed by chemotherapy was the most common treatment modality in 80% patients. Expected 5 year survival for seminomas and non-seminomatous germ cell tumors was 96% and 90% respectively which was not significantly different (p=0.2). Conclusions: Despite a distinct clinical profile of testicular tumors in Pakistani population, survival is comparable with published reports.

      • KCI등재

        DSCE: Comparative Analysis of Heuristic Computational Techniques

        Nooh Bany Muhammad,Sajjad A. Ghauri,Mubashar Sarfraz,Adnan Aftab 대한전자공학회 2021 IEIE Transactions on Smart Processing & Computing Vol.10 No.3

        A frequency-selective fast-fading channel degrades the performance of a signal as it introduces inter-symbol interference (ISI) and inter-carrier interference (ICI). Equalization is the process of eliminating ISI and ICI by adaptively updating the tap weights of the FIR filter. The work presented utilizes various heuristic computational techniques (HCTs) to adaptively update the weights for doubly selective channel equalization (DSCE). Various HCTs are also compared, including genetic algorithms (GAs), particle swarm optimization (PSO), differential evolution (DE), cat swarm optimization (CSO), bee colony optimization (BCO), hybrid GA-PSO (HGP), and the cuckoo search algorithm (CSA). Extensive simulations were performed in MATLAB, and the simulation results show that PSO outperforms the other HCTs in terms of computational time complexity and FoM.

      • KCI등재

        Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells

        Jingjing Wang,Qi Su,Qing Wu,Kun Chen,Asmat Ullah,Mohsin Ahmad Ghauri,Yanmin Zhang 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.11

        Hepatocellular carcinoma (HCC) is one of themost common tumor types globally. Despite the progressmade in surgical procedures and therapeutic options, HCCremains a considerable cause of cancer-related mortality. In this study, we investigated the antitumor eff ects of sanguinarine(Sang) on HCC and its potential mechanisms. Our fi ndings showed that Sang impairs the acidic environmentof lysosomes by inhibiting cathepsin D maturation. Inaddition, Sang inhibited the formation of autolysosomes inRFP-GFP-LC3 transfected cells, subsequently suppressinglate mitophagy. Sang also induced reactive oxygen species(ROS)-dependent autophagy and apoptosis in HCC cells,which was signifi cantly attenuated following treatment witha ROS scavenger. Further investigation using autophagyinhibitors revealed that sanguinarine-induced mitochondrialdysfunction and mitophagy led to mitochondrial apoptosisin HCC cells. Immunohistochemical staining of sanguinarine-treated xenograft samples revealed that it initiated andblocked autophagy. In summary, our fi ndings suggest thatin HCC cells, Sang impairs lysosomal function and inducesROS-dependent mitophagy and apoptosis.

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