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Differential microRNA Expression by Solexa Sequencing in the Sera of Ovarian Cancer Patients
Ji, Ting,Zheng, Zhi-Guo,Wang, Feng-Mei,Xu, Li-Jian,Li, Lu-Feng,Cheng, Qi-Hui,Guo, Jiang-Feng,Ding, Xian-Feng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4
MicroRNAs are a class of small noncoding RNA which play important regulatory roles in a variety of cancers. MiRNA-specific expression profiles have been reported for several pathological conditions. In this study, we combined large scale parallel Solexa sequencing to identify 11 up-regulated miRNAs and 19 down-regulated miRNAs with computational techniques in the sera of ovarian cancer patients while using healthy serum as the control. Among the above, four miRNAs (miR-22, miR-93, miR-106b, miR-451) were validated by quantitative RT-PCR and found to be significantly aberrantly expressed in the serum of ovarian cancer patients (P<0.05). There were no significant differences between samples from cancer stage I/II and III/IV. However, the levels of miR-106b (p=0.003) and miR-451 (p=0.007) were significantly different in those patients under and over 51 yearsof age. MiR-451 and miR-93 were also specific when analyzed with reference to different levels of CA125. This study shows that Solexa sequencing provides a promising method for cancer-related miRNA profiling, and selectively expressed miRNAs could be used as potential serum-based biomarkers for ovarian cancer diagnosis.
( Feng Yun Gong ),( Ding Yu Zhang ),( Jiang Guo Zhang ),( Li Li Wang ),( Wei Li Zhan ),( Jun Ying Qi ),( Jian Xin Song ) 생화학분자생물학회(구 한국생화학분자생물학회) 2014 BMB Reports Vol.47 No.4
To gain insights into the effect of MexB gene under the short interfering RNA (siRNA), we synthesized 21 bp siRNA duplexes against the MexB gene. RT-PCR was performed to determine whether the siRNA inhibited the expression of MexB mRNA. Changes in antibiotic susceptibility in response to siRNA were measured by the E-test method. The efficacy of siRNAs was determined in a murine model of chronic P. aeruginosa lung infection. MexB-siRNAs inhibited both mRNA expression and the activity of P. aeruginosa in vitro. In vivo, siRNA was effective in reducing the bacterial load in the model of chronic lung infection and the P. aeruginosa-induced pathological changes. MexB-siRNA treatment enhanced the production of inflammatory cytokines in the early infection stage (P < 0.05). Our results suggest that targeting of MexB with siRNA appears to be a novel strategy for treating P. aeruginosa infections. [BMB Reports 2014; 47(4): 203-208]
SOME INEQUALITIES AND ABSOLUTE MONOTONICITY FOR MODIFIED BESSEL FUNCTIONS OF THE FIRST KIND
Guo, Bai-Ni,Qi, Feng Korean Mathematical Society 2016 대한수학회논문집 Vol.31 No.2
By employing a refined version of the $P{\acute{o}}lya$ type integral inequality and other techniques, the authors establish some inequalities and absolute monotonicity for modified Bessel functions of the first kind with nonnegative integer order.
TWO NEW PROOFS OF THE COMPLETE MONOTONICITY OF A FUNCTION INVOLVING THE PSI FUNCTION
Guo, Bai-Ni,Qi, Feng Korean Mathematical Society 2010 대한수학회보 Vol.47 No.1
In the present paper, we give two new proofs for the necessary and sufficient condition $\alpha\leq1$ such that the function $x^{\alpha}[lnx-\psi(x)]$ is completely monotonic on (0,$\infty$).
Guo, Miao,Liu, Chao,Qi, Feng-Jie,Zhang, Xiu-Mei,Ren, Li-Li,Liu, Yi-Meng,Meng, Zhi-Chao,Zhu, Zhi-Tu,Xiao, Jian-Ying Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
Aim: To investigate the expression of protein kinase $CK2{\alpha}$ ($CK2{\alpha}$) in human thyroid disease and its relationship with thyroid cancer metastasis. Materials and Methods: Using immunohistochemistry we measured the expression of $CK2{\alpha}$ in 76 benign and malignant human thyroid cancer tissues, including 10 pairs of papillary carcinoma tissues with or without lymph node cancerous metastasis and similarly 10 pairs of lymph nodes. Results: The expression of $CK2{\alpha}$ was found to be higher in thyroid carcinoma cases (papillary carcinoma, follicular carcinoma, anaplastic carcinoma and medullary carcinoma) than in ones such as chronic lymphocytic thyroiditis, nodular goiter and adenoma. These findings were also confirmed by RT-PCR and Western blotting. More strikingly, elevated expression of $CK2{\alpha}$ in thyroid papillary carcinoma tissues was not only significantly associated with lymph node cancerous metastasis and clinical stage of thyroid cancers; but also correlated with epithelial-mesenchymal transition (EMT) and high tenascin C (TNC) expression. In addition, EMT and high TNC expression in thyroid carcinoma tissues was significantly associated with lymph node cancerous metastasis. Conclusions: Elevated expression of nuclear $CK2{\alpha}$ is a poor prognosis indicator in lymph node cancerous metastasis of human thyroid cancers.
SIMPLIFYING AND FINDING ORDINARY DIFFERENTIAL EQUATIONS IN TERMS OF THE STIRLING NUMBERS
Qi, Feng,Wang, Jing-Lin,Guo, Bai-Ni The Kangwon-Kyungki Mathematical Society 2018 한국수학논문집 Vol.26 No.4
In the paper, by virtue of techniques in combinatorial analysis, the authors simplify three families of nonlinear ordinary differential equations in terms of the Stirling numbers of the first kind and establish a new family of nonlinear ordinary differential equations in terms of the Stirling numbers of the second kind.
Guo, Bai-Ni,Qi, Feng Korean Mathematical Society 2011 대한수학회지 Vol.48 No.3
A class of functions involving divided differences of the psi and tri-gamma functions and originating from Kershaw's double inequality are proved to be completely monotonic. As applications of these results, the monotonicity and convexity of a function involving the ratio of two gamma functions and originating from the establishment of the best upper and lower bounds in Kershaw's double inequality are derived, two sharp double inequalities involving ratios of double factorials are recovered, the probability integral or error function is estimated, a double inequality for ratio of the volumes of the unit balls in $\mathbb{R}^{n-1}$ and $\mathbb{R}^n$ respectively is deduced, and a symmetrical upper and lower bounds for the gamma function in terms of the psi function is generalized.
Guo, Kai,Jiang, Naibin,Qi, Huanhuan,Feng, Zhipeng,Wang, Yang,Tan, Wei Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.6
The tubes in a heat exchanger, such as a steam generator (SG), are subjected to crossflow, and interaction between tubes and supports can happen, which can cause fretting wear of tubes. Although many experiments and models have been established, some detailed mechanisms are still not sufficiently clear. In this work, more attention is paid to obtain the regulation of impact and sliding in the complex process and many factors, such as excitation forces and clearances. The responses and contact forces were analyzed to obtain clear understanding of the influences of these factors. Room temperature tests in the air were established. The results show that the effect of clearance on the normal work rate is not monotonous and instead has two peaks. The force ratio can influence the normal work rate by changing the distribution of contact angles, which can result in higher sliding in the contact process. Fretting wear tests are conducted, and the wear surfaces are analyzed by a scanning electron microscope (SEM) and energy dispersive X-ray spectrometer (EDX). The results of this work can serve as a reference for impactsliding contact analysis between AVBs and tubes in steam generators.