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Jia-Feng Wu,Hsu-Heng Yen,Horng-Yuan Wang,Ting-An Chang,Chung-Hsin Chang,Chen-Wang Chang,Te-Hsin Chao,Jen-Wei Chou,Yenn-Hwei Chou,Chiao-Hsiung Chuang,Wen-Hung Hsu,Tzu-Chi Hsu,Tien-Yu Huang,Tsung-I Hung 대한장연구학회 2024 Intestinal Research Vol.22 No.3
Crohn’s disease (CD) is a chronic, fluctuating inflammatory condition that primarily affects the gastrointestinal tract. Although the incidence of CD in Taiwan is lower than that in Western countries, the severity of CD presentation appears to be similar between Asia and the West. This observation indicates the urgency for devising revised guidelines tailored to the unique reimbursement system, and patient requirements in Taiwan. The core objectives of these updated guidelines include the updated treatment choices and the integration of the treat-to-target strategy into CD management, promoting the achievement of deep remission to mitigate complications and enhance the overall quality of life. Given the diversity in disease prevalence, severity, insurance policies, and access to medical treatments in Taiwan, a customized approach is imperative for formulating these guidelines. Such tailored strategies ensure that international standards are not only adapted but also optimized to local contexts. Since the inception of its initial guidelines in 2017, the Taiwan Society of Inflammatory Bowel Disease (TSIBD) has acknowledged the importance of continuous revisions for incorporating new therapeutic options and evolving disease management practices. The latest update leverages international standards and recent research findings focused on practical implementation within the Taiwanese healthcare system.
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Inverse Analysis of Inconel 718 Laser-Assisted Milling to Achieve Machined Surface Roughness
Yixuan Feng,Tsung-Pin Hung,Yu-Ting Lu,Yu-Fu Lin,Fu-Chuan Hsu,Chiu-Feng Lin,Ying-Cheng Lu,Xiaohong Lu,Steven Y. Liang 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.19 No.11
This manuscript proposes an inverse analysis method for the machined surface roughness in laser-assisted milling on Inconel 718. The method solves the forward problem considering the tool profile and the elastic recovery of machined surface and applies the variance-based recursive method to guide the updating mechanism of process parameters to match the measurements. Subsequently, the inverse analysis identifies four process parameters of feed per tooth, tool tip radius, minimum cutting thickness, and tool tip angle, and finds the optimal solution for target performance, the surface roughness. The measurements are collected under the single beam coaxial laser-assisted milling spindle. The proposed modified Kalman filter algorithm introduces the gain coefficient G when updating the process parameters to improve robustness and accuracy. The inverse analysis is conducted on all measurements, and the average error of target performance is 0.460% when the laser is on and 0.394% when the laser is off. The average difference of process parameters is less than 5%, and the selection process is done in 50 loops within a minute. Therefore, the proposed inverse analysis model is robust, adaptive to different initial guesses and measurements, highly accurate, and saves computation time.
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A GPU-based Two Dimensional Flood Simulation System
Kuo-Chan Hung,Chih-Yung Feng,Kun-Huai Cheng,Pei-Cheng Tsao1,Hung-Kwai Chen 한국방재학회 2016 Journal of Disaster Management Vol.1 No.1
Abstract A GPU-based flood simulation system is developed in this research. The system comprises two main components: a GPU-lized two bdimensional flood simulation model named GLMRT and a web-GIS user interface. GLMRT is designed and constructed with following features. First, GLMRT is constructed based on Lattice Boltzmann method(LBM) and two dimensional shallow water equations. Second, GLMRT is combined with sink/source terms including excess rainfall and pump-like drainage. Third, a dry-wet boundary determining mechanism is considered in GLMRT. Fourth, real DEM data can be used in simulating water movement on the land surface. Finally, GPU accelerated technique is integrated into GLMRT to overcome the issue of time cost in calculation. The web-GIS based user interface is built based on cloud platform to assist data flow organization and real time simulation. The interface integrates real DEM data and receives precipitation estimation products from the Taiwan Typhoon and Flood Research Institute(TTFRI) and Central Weather Bureau(CWB). The simulation results would be displayed on the web-GIS via file and database transfer. Besides, a real time rendering technique based on real time simulation is developed, too. The real time rendering technique displays the simulation results via memory on GPU device and eliminates the time cost in data output. GLMRT solves a 800-second simulation of Zengwen Reservoir virtual dam break with 2,046x1,525 DEM grids (40 m resolution) within 140.11 seconds on the NVIDIA Tesla K20c. Compare to the 60,919 seconds computation time on the Intel?? Xeon?? CPU X5650 2.66GHz, the GLMRT gets a speedup of 438x. On the other hand, using GLMRT alone to simulate a 12-hour rainfall duration induced inundation would spend about 1.2 hours, which can provide buffer time for the requirement of flood prevention operation. Abstract A GPU-based flood simulation system is developed in this research. The system comprises two main components: a GPU-lized two bdimensional flood simulation model named GLMRT and a web-GIS user interface. GLMRT is designed and constructed with following features. First, GLMRT is constructed based on Lattice Boltzmann method(LBM) and two dimensional shallow water equations. Second, GLMRT is combined with sink/source terms including excess rainfall and pump-like drainage. Third, a dry-wet boundary determining mechanism is considered in GLMRT. Fourth, real DEM data can be used in simulating water movement on the land surface. Finally, GPU accelerated technique is integrated into GLMRT to overcome the issue of time cost in calculation. The web-GIS based user interface is built based on cloud platform to assist data flow organization and real time simulation. The interface integrates real DEM data and receives precipitation estimation products from the Taiwan Typhoon and Flood Research Institute(TTFRI) and Central Weather Bureau(CWB). The simulation results would be displayed on the web-GIS via file and database transfer. Besides, a real time rendering technique based on real time simulation is developed, too. The real time rendering technique displays the simulation results via memory on GPU device and eliminates the time cost in data output. GLMRT solves a 800-second simulation of Zengwen Reservoir virtual dam break with 2,046x1,525 DEM grids (40 m resolution) within 140.11 seconds on the NVIDIA Tesla K20c. Compare to the 60,919 seconds computation time on the Intel?? Xeon?? CPU X5650 2.66GHz, the GLMRT gets a speedup of 438x. On the other hand, using GLMRT alone to simulate a 12-hour rainfall duration induced inundation would spend about 1.2 hours, which can provide buffer time for the requirement of flood prevention operation.
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Proteomic analysis of amino acid metabolism differences between wild and cultivated Panax ginseng
Hang Sun,Fangbing Liu,Liwei Sun,Jianzeng Liu,Manying Wang,Xuenan Chen,Xiaohao Xu,Rui Ma,Kai Feng,Rui Jiang 고려인삼학회 2016 Journal of Ginseng Research Vol.40 No.2
Background: The present study aimed to compare the relative abundance of proteins and amino acid metabolites to explore the mechanisms underlying the difference between wild and cultivated ginseng (Panax ginseng Meyer) at the amino acid level. Methods: Two-dimensional polyacrylamide gel electrophoresis and isobaric tags for relative and absolute quantitation were used to identify the differential abundance of proteins between wild and cultivated ginseng. Total amino acids in wild and cultivated ginseng were compared using an automated amino acid analyzer. The activities of amino acid metabolism-related enzymes and the contents of intermediate metabolites between wild and cultivated ginseng were measured using enzyme-linked immunosorbent assay and spectrophotometric methods. Results: Our results showed that the contents of 14 types of amino acids were higher in wild ginseng compared with cultivated ginseng. The amino acid metabolism-related enzymes and their derivatives, such as glutamate decarboxylase and S-adenosylmethionine, all had high levels of accumulation in wild ginseng. The accumulation of sulfur amino acid synthesis-related proteins, such as methionine synthase, was also higher in wild ginseng. In addition, glycolysis and tricarboxylic acid cycle-related enzymes as well as their intermediates had high levels of accumulation in wild ginseng. Conclusion: This study elucidates the differences in amino acids between wild and cultivated ginseng. These results will provide a reference for further studies on the medicinal functions of wild ginseng.
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Iterative Symbol Decoding of Variable-Length Codes with Convolutional Codes
Hung-Tsai Wu,Chun-Feng Wu,Wen-Whei Chang 한국통신학회 2016 Journal of communications and networks Vol.18 No.1
In this paper, we present a symbol-level iterative sourcechanneldecoding (ISCD) algorithm for reliable transmission ofvariable-length codes (VLCs). Firstly, an improved source a posterioriprobability (APP) decoding approach is proposed for packetizedvariable-length encoded Markov sources. Also proposed is arecursive implementation based on a three-dimensional joint trellisfor symbol decoding of binary convolutional codes. APP channeldecoding on this joint trellis is realized by modification of theBahl-Cocke-Jelinek-Raviv algorithm and adaptation to the nonstationaryVLC trellis. Simulation results indicate that the proposedISCD scheme allows to exchange between its constituent decodersthe symbol-level extrinsic information and achieves high robustnessagainst channel noises.
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Hung The Nguyen,이변우,Lan The Nguyen,Yong-Feng Yan,Kyu-Jong Lee 한국작물학회 2007 Journal of crop science and biotechnology Vol.10 No.1
Nitrogen management at the panicle initiation stage (PI) should be fine-tuned for securing a concurrent high yield and high quality rice production. For calibration and testing of the recommendation models of N topdressing rates at PI for target grain yield and protein content of rice, three split-split-plot design experiments including five rice cultivars and various N rates were conducted at the experimental farm of Seoul National University, Korea from 2003 to 2005. Data from the first two years of experiments were used to calibrate models to predict grain yield and milled-rice protein content using shoot fresh weight (FW), chlorophyll meter value (SPAD), and the N topdressing rate (Npi) at PI by stepwise multiple regression. The calibrated models explained 85 and 87% of the variation in grain yield and protein content, respectively. The calibrated models were used to recommend Npi for the target protein content of 6.8%, with FW and SPAD measured for each plot in 2005. The recommended N rate treatment was characterized by an average protein content of 6.74% (similar to the target protein content), reduced the coefficient of variation in protein content to 2.5% (compared to 4.6% of the fixed rate treatment), and increased grain yield. In the recommended N rate treatments for the target protein content of 6.8%, grain yield was highly dependent on FW and SPAD at PI. In conclusion, the models for N topdressing rate recommendation at PI were successful under present experimental conditions. However, additional testing under more variable environmental conditions should be performed before universal application of such models. Nitrogen management at the panicle initiation stage (PI) should be fine-tuned for securing a concurrent high yield and high quality rice production. For calibration and testing of the recommendation models of N topdressing rates at PI for target grain yield and protein content of rice, three split-split-plot design experiments including five rice cultivars and various N rates were conducted at the experimental farm of Seoul National University, Korea from 2003 to 2005. Data from the first two years of experiments were used to calibrate models to predict grain yield and milled-rice protein content using shoot fresh weight (FW), chlorophyll meter value (SPAD), and the N topdressing rate (Npi) at PI by stepwise multiple regression. The calibrated models explained 85 and 87% of the variation in grain yield and protein content, respectively. The calibrated models were used to recommend Npi for the target protein content of 6.8%, with FW and SPAD measured for each plot in 2005. The recommended N rate treatment was characterized by an average protein content of 6.74% (similar to the target protein content), reduced the coefficient of variation in protein content to 2.5% (compared to 4.6% of the fixed rate treatment), and increased grain yield. In the recommended N rate treatments for the target protein content of 6.8%, grain yield was highly dependent on FW and SPAD at PI. In conclusion, the models for N topdressing rate recommendation at PI were successful under present experimental conditions. However, additional testing under more variable environmental conditions should be performed before universal application of such models.
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Feng-Xue Jin,Xiao-Bo Xie,Shi-Dong Ji,Hong-Guang Ju,Jung-Pil Suh,Hung-Goo Hwang,Sang-Nag Ahn 한국작물학회 2008 한국작물학회 학술발표대회 논문집 Vol.2008 No.10
Grain weight (GW) or grain size is the most important target not only as a major component of grain yield, but also associated with the cooking quality in rice breeding program. In a previous study, two loci for grain weight, gw8 and gw9, have been fine map to about 306.4kb and 37.4kb, respectively, in backcross populations derived from a cross between the Korean japonica cultivar Hwaseongbyeo and Oryza rufipigon (IRGC 105491). Both O.rufipogon alleles increased GW in the Hwaseongbyeo background despite the fact that O. rufipogon was the small-seeded parent. To test the effect of pyramiding the QTLs for grain weight, an F2 population consisted of 226 individuals was developed derived from the cross between the two QTLs (gw8 and gw9), and used MAS to select nearly isgenic lines for two QTLs and a pyramiding line. Molecular genotyping of F2 population revealed the existence of interaction between gw8 and gw9. Moreover, the interaction was also confirmed by phenotypic analysis of four QTL-NILs. The results suggest that epistasis interaction is important genetic basis in determining yield traits in rice.
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3.2-kW 9.7-GHz Polarization-maintaining Narrow-linewidth All-fiber Amplifier
Hang Liu,Yujun Feng,Xiaobo Yang,Yao Wang,Hongming Yu,Jue Wang,Wanjing Peng,Yanshan Wang,Yinhong Sun,Yi Ma,Qingsong Gao,Chun Tang 한국광학회 2024 Current Optics and Photonics Vol.8 No.1
We present a Yb-doped narrow-linewidth polarization-maintaining (PM) all-fiber amplifier that achieves a high mode-instability (MI) threshold, high output power, and 9.7-GHz spectral linewidth. Six wavelength-multiplexed laser diodes are used to pump this amplifier. First, we construct a high-power fiber amplifier based on a master oscillator-power amplifier (MOPA) configuration for experiments. Subsequently, we examine the MI threshold by individually pumping the amplifier with wavelengths of 976, 974, 981, 974, and 981 nm respectively. The experimental results demonstrate that the amplifier exhibits a high MI threshold (>3.5 kW) when pumped with a combination of wavelengths at 974 and 981 nm. Afterward, we inject an optimized phase-modulated seed with a nearly flat-top spectrum into this amplifier. Ultimately, laser output of 3.2 kW and 9.7 GHz are obtained.
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