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RISS 인기검색어
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- 저자 : Feiyi Yang (검색결과 3 건)
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Impact of Grafting Density on the Self-Assembly and Hydrophilicity of Succinylated Collagen
Wenxin Wang,Feiyi Shu,Lingyu Pan,Shanshan Huang,Xiao Tu,Ping Li,Siman Li,Yuanyuan Li,Chengzhi Xu,Yang Sun,Juntao Zhang,Haibo Wang 한국고분자학회 2020 Macromolecular Research Vol.28 No.6
Modification of protein could give their new functionality but would affect their intrinsic property and activity. In this paper, a series of succinylated collagen (SCol(n/1)) (n≥1) were prepared by modification of collagen with succinic anhydride at different molar ratio to amino groups amount of collagen. The impact of grafting density on the intrinsic self-assembly and additional hydrophilicity of succinylated collagen was explored. The results revealed that excessive grafting density of succinylated collagen would improve their hydrophilicity but weaken their self-assembly property, although the triple helix of collagen could be reserved after succinylation. SCol(1/1) (grafting density of 17%) with self-assembly property and good hydrophilicity was chosen to compare with native collagen. Compared to native collagen, thermostability of SCol(1/1) decreased slightly, however, SCol(1/1) could form softer hydrogel, which was more favorable for the proliferation of NIH/3 T3. The present work would help us to further understand the importance of grafting density for the design of modified collagen with intrinsic self-assembly property and additional new functionality.
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Preparation of nano aluminum nitride powders by polymer network method
Ning Zhang,Tingting Fu,Feiyi Yang,Hongmin Kan,Xiaoyang Wang,Haibo Long,Liuyan Wang 한양대학교 세라믹연구소 2014 Journal of Ceramic Processing Research Vol.15 No.2
In this work, aluminum nitrate (Al(NO3)3), active carbon and C12H22O11 were used as raw materials. The nano aluminum nitride powders (AlN) were synthesis by polymer network method. Aluminum nitride (AlN) exhibits high thermal conductivity, low dielectric permittivity and good electric insulativity. It has a very high synthetic temperature, however, results in a high cost. The aim of this investigation is to develop a new method of fabricating ultra-fine AlN powders to lower the synthetic temperature of AlN. The influences of different carbon sources and the synthetic temperature on fabricating AlN powders via polymer network method were investigated, and the mechanism of AlN formation was also identified. The results indicated that as using sucrose (C12H22O11) as the carbon source, the optimum synthetic process condition for fabricating ultrafine AlN powders was at 1500 °C for 2 h. Comparing with the mechanical ball-milling method, the temperature of synthesizing AlN powders was lowered about 100 °C. Furthermore, the size of as-synthesized AlN was finer from 50 nm to 80 nm.
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Chen Chao,Du Shiyu,Zhong Wu,Liu Kunguo,Qu Lihua,Chu Feiyi,Yang Jingjing,Han Xin 나노기술연구협의회 2022 Nano Convergence Vol.9 No.52
Chemoresistance remains a huge challenge for effective treatment of non-small cell lung cancer (NSCLC). Previous studies have shown Chinese herbal extracts possess great potential in ameliorating tumor chemoresistance, however, the efficacy is clinically limited mainly because of the poor tumor-targeting and in vivo stability. The construction of nano-delivery systems for herbal extracts has been shown to improve drug targeting, enhance therapeutic efficacy and reduce toxic and side effects. In this study, a folic acid (FA)-modified nano-herb micelle was developed for codelivery of pristimerin (PRI) and paclitaxel (PTX) to enhance chemosensitivity of NSCLC, in which PRI could synergistically enhance PTX-induced growth inhibition of A549 cancer cell. PTX was firstly grafted with the FA-linked polyethylene glycol (PEG) and then encapsulated with PRI to construct the PRI@FA-PEG-PTX (P@FPP) nano-micelles (NMs), which exhibited improved tumor-targeting and in vivo stability. This active-targeting P@FPP NMs displayed excellent tumor-targeting characteristics without obvious toxicity. Moreover, inhibition of tumor growth and metastasis induced by P@FPP NMs were significantly enhanced compared with the combined effects of the two drugs (PRI in combination of PTX), which associated with epithelial mesenchymal transition inhibition to some extent. Overall, this active-targeting NMs provides a versatile nano-herb strategy for improving tumor-targeting of Chinese herbal extracts, which may help in the promotion of enhancing chemosensitivity of NSCLC in clinical applications.
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