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RISS 인기검색어
- 검색키워드
- 저자 : Esra Maltaş (검색결과 3 건)
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Mevlüt Bayrakcı,Esra Maltaş,Şengül Yiğiter,Mustafa Özmen 한국고분자학회 2013 Macromolecular Research Vol.21 No.9
This article is the first report showing the human serum albumin (HSA) binding studies by using a new magnetite nanoparticle containing azacrown ether moieties via solid-liquid extraction process. The structure of the newly prepared magnetite nanoparticle was clarified by using attenuated total reflectance (ATR) infrared spectroscopy,scanning electron microscopy (SEM), UV-vis and elemental analysis. Analytic results indicated that modification of the surface of the magnetite nanoparticles with azacrown ether derivative was successfully carried out. The protein binding studies exhibited that the modified magnetite nanoparticles could be efficiently used for the binding of the human serum albumin (HSA) in aqueous solutions via non-covalent interaction between crown ether cavity and amino group of the protein.
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Fatih Ozcan,Esra Maltas Cagil 한국고분자학회 2024 Macromolecular Research Vol.32 No.4
In this work, new pH-sensitive hexagonal boron nitride–polysaccharides nanosystems were produced using sol–gel method. These hybrid sol–gel systems include β-cyclodextrin (β-CD), dextrin (Dex), shellac wax (Wax), and polyethylene glycol which were synthesized with hexagonal boron nitride (h-BN) by coupling of triethyl orthosilicate and donepezil. The release studies of DNP from each sol–gel systems were studied using buffers at various pH levels such as 2.2, 4.0, 6.0, 7.4, and 8.6. The release percentages of the drug were calculated by regression equations of the DNP which has maximum fluorescence intensity at 325 and 387 nm excitation and emission wavelengths. These new sol–gel hexagonal boron nitride systems were characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, and scanning electron microscopy analysis. According to the results. The sol–gel systems with polysaccharide-based dextrin (h-BN–Dex) and shellac wax (h-BN–Wax) were more available at a pH levels of 6, 7.4, and 8.6 for the release of DNP.
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Kubra Yilmaz,Ilkay Hilal Gubbuk,Esra Maltas Cagil 한국고분자학회 2024 Macromolecular Research Vol.32 No.1
A new pH stimuli drug carrier platform was fabricated based on amine modified sporopollenin for targeted and controlled drug delivery. For this purpose, human serum albumin (HSA) was immobilized on 3-aminopropyltrimethoxysilane functionalized sporopollenin (Sp-APTS). Then, irinotecan (IR) was loaded to the albumin modified sporopollenin at various pH levels (2.2, 4.0, 6.0, 7.4, and 9.0). The release studies of irinotecan from drug loaded sporopollenin systems were carried out by using buffers at various pH levels such as 2.2, 4.0, 6,0, 7.4, and 9.0. The loading and release amount of IR were determined by using fluorescence spectroscopy. the results showed that the maximum loading pH was pH 4.0 with 23.44 μg. we evaluate the results in terms of the controlled release, the systems are more controllable towards basic region after pH 4.0 depends on time and pH level. Characterization of the systems was run by using thermal gravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) analysis. One of the biodegradable biopolymers, polysaccharide based controlled drug delivery system makes the pharmaceutical formulation more bioavailable in cancer therapy.
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