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- 저자 : Epplein, Meira (검색결과 1 건)
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Validation of a Blood Biomarker for Identification of Individuals at High Risk for Gastric Cancer
Epplein, Meira,Butt, Julia,Zhang, Yang,Hendrix, Laura H.,Abnet, Christian C.,Murphy, Gwen,Zheng, Wei,Shu, Xiao-Ou,Tsugane, Shoichiro,Qiao, You-lin,Taylor, Philip R.,Shimazu, Taichi,Yoo, Keun-Young,Par American Association for Cancer Research 2018 Cancer Epidemiology, Biomarkers & Prevention Vol.27 No.12
<P><B>Background:</B></P><P><I>Helicobacter pylori</I> is the leading cause of gastric cancer, yet the majority of infected individuals will not develop neoplasia. Previously, we developed and replicated serologic <I>H. pylori</I> biomarkers for gastric cancer risk among prospective cohorts in East Asia and now seek to validate the performance of these biomarkers in identifying individuals with premalignant lesions.</P><P><B>Methods:</B></P><P>This cross-sectional study included 1,402 individuals from Linqu County screened by upper endoscopy. <I>H. pylori</I> protein-specific antibody levels were assessed using multiplex serology. Multivariable-adjusted logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for prevalent intestinal metaplasia, indefinite dysplasia, or dysplasia, compared with superficial or mild atrophic gastritis.</P><P><B>Results:</B></P><P>Compared with individuals seronegative to Omp and HP0305, individuals seropositive to both were seven times more likely to have precancerous lesions (OR, 7.43; 95% CI, 5.59–9.88). A classification model for precancerous lesions that includes age, smoking, and seropositivity to <I>H. pylori</I>, Omp, and HP0305 resulted in an area under the curve (AUC) of 0.751 (95% CI, 0.725–0.777), which is significantly better than the same model, including the established gastric cancer risk factor CagA (AUC, 0.718; 95% CI, 0.691–0.746, <I>P</I><SUB>difference</SUB> = 0.0002).</P><P><B>Conclusions:</B></P><P>The present study of prevalent precancerous gastric lesions provides support for two new serum biomarkers of gastric cancer risk, Omp and HP 0305.</P><P><B>Impact:</B></P><P>Our results support further research into the serological biomarkers Omp and HP0305 as possible improvements over the established virulence marker CagA for identifying individuals with precancerous lesions in East Asia.</P>
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