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Use of aglepristone for the treatment of P4 induced insulin resistance in dogs
Enrico Bigliardi,Carla Bresciani,Daniela Callegari,Francesco Di Ianni,Giorgio Morini,Enrico Parmigiani,Ezio Bianchi 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.2
Insulin resistance (IR) in dogs is suspected whenhyperglycemia is present despite administration of insulindoses greater than 1.0 to 1.5 UI/kg. IR is caused by increasesin counter regulatory hormones concentrations (glucagon,glucocorticoids, catecholamines and growth hormone). Thisstudy was conducted to investigate the use of aglepristone(RU 46534), a P4 receptor antagonist, for the treatment of IRdiabetes mellitus in bitches during the luteal phase. Allanimals were treated with porcine insulin zinc suspension(Caninsulin) and aglepristone (Alizin) 10 mg/kgsubcutaneously at day 1, 2, 9 and 17 from diagnosis. At day5, no significant variation in glycemia was shown. At day 12and 20, serum glucose concentrations were significant lower(p < 0.05). From day 12 the insulin dose was reduced to 0.8IU BID. Insulin was reduced in the following weeks andglycemia was controlled.