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Rukiye Sevinc Ozakar,Mehmet Semih Bingol,Mehmet Cemal Adıguzel,Emrah Ozakar 한국고분자학회 2022 폴리머 Vol.46 No.6
Many studies have reported that the widespread use and abuse of antibiotics have led to the emergence of multidrug-resistant bacteria, a significant weakness of current antibiotic therapy. Therefore, the present scenario motivates scientists to develop biocompatible nanoparticles (Nps) that apply better antibacterial effects and biocompatible properties, including cost-effectiveness. The aim of this study was to evaluate the antibacterial effect of boron nitride (BN) and chitosan coated BN-Nps using different surfactants. In this regard, the potential antibacterial activity of prepared chitosan-coated and non-coated BN-Nps have been investigated against nine reference bacteria strains. BN-Nps and chitosan-coated BN-Nps were successfully developed and characterized. Nps determined that showed high zeta potential values (between -20.1 mV and +59.2 mV). Antimicrobial resistance results indicated that formulations of BN-Nps with negative zeta potential were found to be effective compared to chitosan-coated BN-Nps with high positive zeta potential. These findings emphasize the future availability of BN-Nps formulation providing antibacterial activity.