http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Mi-Sook Dong,Suk-Kyung Chang,Hyun-Jung Kim,Elizabeth M. J. Gillam,F. Peter Guengerich,Young In Park 한국환경성돌연변이발암원학회 2002 한국환경성돌연변이·발암원학회지 Vol.22 No.3
Resveratrol is known to have potent cancer chemopreventive activity against tumorigenesis caused by 7,12-dimethylbenz[α]anthracene (DMBA) which is known to be oxidized to reactive products by cytochrome P450 1B1 (CYP1B1). The effects of resveratrol on the activity of recombinant human P450 1 family enzymes, expressed in Escherichia coli membranes with human NADPH-P450 reductase, were determined by measuring alkoxyresorufin O-dealkylation activity, e.g., ethoxyresorufin O-deethylation (EROD) CYP1A1, methoxyresorufin O-demethylation (MROD), CYP1A2, benzyloxyresorufin-O-debenzylation (BROD), CYP1B1. Resveratrol<br/> inhibited CYP1B1 and CYP1A1 activities in a dose-dependent manner with IC50 values of 59 and 10 μM for EROD activity and 1.8 and 30 μM for BROD activity, respectively. Resveratrol had only weak inhibitory effect on CYP1A2 activity (IC50 values of 0.44 mM for EROD and >2 mM for MROD). Furthermore, resveratrol did not affect NADPH-P450 reductase activity significantly. Resveratrol inhibited the CYP1B1-dependent EROD activity with a Ki of 28 μM in a non-competitive type manner. These results suggest that resveratrol-derived inhibition of CYP1B1 and CYP1A1 activities may contribute to the suppression of DMBA inducible tumorigenesis observed in extrahepatic tissues.