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Synthesis of certain thiaxanthones as potential schistosomicidal agents
El-Kerdawy, M.M.,El-Eman, A.A.,El-Subbagh, H.I. The Pharmaceutical Society of Korea 1986 Archives of Pharmacal Research Vol.9 No.1
Twenty nine substituted thiaxanthone derivatives were synthesized for schistosomicidal evaluation. The compounds, 1-morpholino-4-methyl-6-nitrothiaxanthone and 1-(2-diethyl-aminoethyl-amino)-4 methyl-6-nitrothiaxanthone dipicrate were found to possess promising schistosomicidal activity against Schistosoma mansoni in mice.
Synthesis of Substituted Arylazothioxanthones as Potential Schistosomicidal Agents
El-Kerdawy, M.M.,El-Emam, A.A.,El-Subbagh, H.I.,Abushanab, E. The Pharmaceutical Society of Korea 1989 Archives of Pharmacal Research Vol.12 No.1
A series of 1-chloro-4-methyl-6-arylazo-9H-thioxanthen-9-ones were synthesized and schistosomicidal activity evaluated. It was found that, 1-chloro-4-methyl-6-(2-hydroxy-1-naphthylazo)-9H-thioxanthen-9-one possessed a promising activity against Schisto-soma mansoni in mice.
El-Subbagh, H.I.,El-Emam, A.A.,El-Ashmawy, M.B.,Shehata, I.A. The Pharmaceutical Society of Korea 1990 Archives of Pharmacal Research Vol.13 No.1
Reaction of 2-formyl-4H-thieno [2, 3-b] benzothiopyran-4-one (1) with different heterocyclic amines afforded the corresponding Schiff's bases (2-4). Diethyl malonate, ethyl cyanoacetate and malononitrile were reached with 1 to afford compounds 5, 7 and 8, respectively. Compound 5 was cyclized to the pyrazolidin-3, 4-dione (6) by the action of hydrazine hydrate, whereas compound 7 was utilized for the synthesis of the thiazolin-4 one derivatives (9-13).
El-Subbagh, H.I.,Yousif, M.Y.,El-Eman, A.A.,El-Kerdawy, M.M. The Pharmaceutical Society of Korea 1989 Archives of Pharmacal Research Vol.12 No.2
A convenient route is reported for the synthesis of certain series of 4H-thieno[2,3-b][1]benzothiopyran-4-ones, carrying various substituents at position 2 such as arylazomethines (7,8), thiazolidin-4-ones (9-13), ${\alpha},\;{\beta}-unsaturated$ ketones (16,17), 2-pyridones (19-23), tetrahydrothiophen-4-ones (24,28), and nitroalkenes (29,30), as potential schistosomicidal or antihistaminic agents.