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Elastin-Based Rubber-Like Hydrogels
Desai, Malav S.,Wang, Eddie,Joyner, Kyle,Chung, Tae Won,Jin, Hyo-Eon,Lee, Seung-Wuk American Chemical Society 2016 Biomacromolecules Vol.17 No.7
<P>We developed rubber-like elastomeric materials using a natural elastin derived sequence and genetic engineering to create precisely defined elastin-like polypeptides. The coiled elastin-like polypeptide chains, which behave like entropic springs, were cross-linked using an end-to-end tethering scheme to synthesize simple hydrogels with excellent extensibility and reversibility. Our hydrogels extend to strains as high as 1500% and remain highly resilient with elastic recovery as high as 94% even at 600% strain, significantly exceeding any other protein-based valuable as elastomeric hydrogels for designing extremely robust scaffolds useful for tissue engineering.</P>
Microscopic Study of Hydroxyapatite Dissolution As Affected by Fluoride Ions
Kwon, Ki-Young,Wang, Eddie,Nofal, Michel,Lee, Seung-Wuk American Chemical Society 2011 Langmuir Vol.27 No.9
<P>Fluoride ions play a critical role in preventing tooth decay. We investigated the microscopic effects of fluoride ions on hydroxyapatite (100) surface dissolution using in situ atomic force microscopy. In the presence of 10 mM NaF, individual surface step retraction velocities decreased by about a factor of 5 as compared to NaF-free conditions. Importantly, elongated hexagonal etch pits, which are characteristic of (100) surface dissolution, were no longer observed when NaF was present. The alteration of pit shape is more distinct at a higher NaF concentration (50 mM) where triangular etch pits evolved during dissolution. Furthermore, in a fluoride concentration typical for tap water (10 μM), we observed roughening of individual step lines, resulting in the formation of scalloped morphologies. Morphological changes to individual steps across a wide range of fluoride concentrations suggest that the cariostatic capabilities of fluoride ions originate from their strong interactions with molecular steps.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2011/langd5.2011.27.issue-9/la200325d/production/images/medium/la-2011-00325d_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/la200325d'>ACS Electronic Supporting Info</A></P>
Biomimetic Self-Templated Hierarchical Structures of Collagen-Like Peptide Amphiphiles
Jin, Hyo-Eon,Jang, Jaein,Chung, Jinhyo,Lee, Hee Jung,Wang, Eddie,Lee, Seung-Wuk,Chung, Woo-Jae American Chemical Society 2015 NANO LETTERS Vol.15 No.10
<P>Developing hierarchically structured biomaterials with tunable chemical and physical properties like those found in nature is critically important to regenerative medicine and studies on tissue morphogenesis. Despite advances in materials synthesis and assembly processes, our ability to control hierarchical assembly using fibrillar biomolecules remains limited. Here, we developed a bioinspired approach to create collagen-like materials through directed evolutionary screening and directed self-assembly. We first synthesized peptide amphiphiles by coupling phage display-identified collagen-like peptides to long-chain fatty acids. We then assembled the amphiphiles into diverse, hierarchically organized, nanofibrous structures using directed self-assembly based on liquid crystal flow and its controlled deposition. The resulting structures sustained and directed the growth of bone cells and hydroxyapatite biominerals. We believe these self-assembling collagen-like amphiphiles could prove useful in the structural design of tissue regenerating materials.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2015/nalefd.2015.15.issue-10/acs.nanolett.5b03313/production/images/medium/nl-2015-03313d_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl5b03313'>ACS Electronic Supporting Info</A></P>
Selective and Sensitive TNT Sensors Using Biomimetic Polydiacetylene-Coated CNT-FETs
Kim, Tae Hyun,Lee, Byung Yang,Jaworski, Justyn,Yokoyama, Keisuke,Chung, Woo-Jae,Wang, Eddie,Hong, Seunghun,Majumdar, Arun,Lee, Seung-Wuk American Chemical Society 2011 ACS NANO Vol.5 No.4
<P>Miniaturized smart sensors that can perform sensitive and selective real-time monitoring of target analytes are tremendously valuable for various sensing applications. We developed selective nanocoatings by combining trinitrotoluene (TNT) receptors bound to conjugated polydiacetylene (PDA) polymers with single-walled carbon nanotube field-effect transistors (SWNT-FET). Selective binding events between the TNT molecules and phage display derived TNT receptors were effectively transduced to sensitive SWNT-FET conductance sensors through the PDA coating layers. The resulting sensors exhibited an unprecedented 1 fM sensitivity toward TNT in real time, with excellent selectivity over various similar aromatic compounds. Our biomimetic receptor coating approach may be useful for the development of sensitive and selective micro- and nanoelectronic sensor devices for various other target analytes.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2011/ancac3.2011.5.issue-4/nn103324p/production/images/medium/nn-2010-03324p_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn103324p'>ACS Electronic Supporting Info</A></P>