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Effect of norgalanthamine on renal injury induced by carbon tetrachloride in mice
Nayeon Yang,Myungsoon Ko,Minhwa Jang,Eunjun Jang,Dowook Yu,Wootaek Hong,Seongbeom Bae,Jieun Ryoo,Taekyun Shin,Meejung Ahn 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Norgalanthamine is a major component of Crinum asiaticum var. japonicum that exhibits several biological activities. This study evaluated the anti-inflammatory and anti-oxidative properties of norgalanthamine in mice with carbon tetrachloride (CCl4)-induced renal injury. Norgalanthamine (1 and 10 mg/kg) was orally administered to mice for 7 or 14 days, after which renal injury was induced by CCl4 (1.5 ml/kg, i.p.). The vehicle and positive controls consisted of phosphate-buffered saline and silymarin (100 mg/kg), respectively. In CCl4-injured mice, norgalanthamine pretreatment significantly reversed the increases in serum alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels, and the decrease in the serum glucose level. The histopathological evaluation and Iba-1 immunoreactivity also supported the protective effects of norgalanthamine against CCl4-induced kidney injury. These results suggest that norgalanthamine ameliorates oxidative renal injury, possibly through reducing enhancing antioxidant enzymes, and suppressing infiltrated macrophages.