정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Doo`s SACSIH 수술과 전자궁적출술후 환자와 배우자가 느끼는 심신의학적인 면에서의 비교연구

두재균(JK Doo),이민아(MA Lee),박경배(KB Park),채규정(GJ Chae),김관식(KS Kim),안석문(SM Ahn),유은영(EY Yoo),김난경(NK Kim),나미옥(MO Na) 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.2

Since November 18 of 1992, we have undertaken a comparative study concerning the patients and their spouses at least five months after the operation. We chose 31 patients who were operated by Koos SACSIH operation and the same number of the patients who and psychsomatic aspects occured after each operation. And we cmae to the following conclusion: 1 Of the patients subjective complaints, weight gain was the highest after Koos SACSIH:32.3%; decrease in sexual desire was the highest after TAH: 29.1%. 2. 51.6% of the patient after Koos SACSIH had no complaint of pelvic pain and lumbago and 32.3% after TAH. 3. 19.3% of the patients after Koos SACSIH complain of decrease in sexual desire and 32.3% after TAH. 4. 33.3% of the patients in their forties after Koos SACSIH had coital frequency less than once in 2 weeks and 78.9% after TAH(PP

Facile and fast Na-ion intercalation employing amorphous black TiO_2-x/C composite nanofiber anodes

Lee, Na-Won,Jung, Ji-Won,Lee, Jun-Seo,Jang, Hye-Yeon,Kim, Il-Doo,Ryu, Won-Hee Elsevier 2018 ELECTROCHIMICA ACTA Vol.263 No.-

<P><B>Abstract</B></P> <P>Structural and electronic modification of titanium oxide (TiO<SUB>2</SUB>) nanomaterials induced by the co-introduction of fully disordered glass phase and oxygen vacancies can lead to remarkable advances in the electrode performance in emerging energy storage systems. We report on the effective co-creation of fully amorphous nanofibers (NFs) composed of black TiO<SUB>2-x</SUB> and conductive carbons throughout the NF structure, and evaluate the materials as potential anodes in sodium-ion batteries. The black TiO<SUB>2-x</SUB> nanofiber is successfully fabricated by electrospinning a precursor solution followed by a two-step sequential thermal treatment in an air and reducing atmosphere. The NF electrode could deliver approximately two-fold higher 2nd discharge capacity and an excellent kinetic performance even under high rates compared to that delivered by anatase-structured white TiO<SUB>2</SUB> NFs used as reference, because of (i) an inherent free volume in the glass phase corresponding to the enlarged Na<SUP>+</SUP> sites, (ii) increased electrical conductivity (low bandgap) resulting from the presence of Ti<SUP>3+</SUP>, (iii) introduction of conductive carbon agents around the TiO<SUB>2-x</SUB> domain, and (iv) one-dimensional NF feature allowing numerous Na<SUP>+</SUP> reaction sites at the electrochemical interface. We also elucidate the morphological and structural changes in the nanofibers after discharge and charge by <I>ex-situ</I> characterizations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We succeed in co-creating amorphous nanofiber structure composed of black TiO<SUB>2-x</SUB> and conductive carbons. </LI> <LI> Black TiO<SUB>2-x</SUB>/carbon nanofibers are prepared by electrospinning followed by a two-step thermal treatment. </LI> <LI> Black TiO<SUB>2-x</SUB>/carbon nanofiber delivers excellent electrochemical performance compared to those of anatase TiO<SUB>2</SUB> nanofiber. </LI> <LI> The benefits and reaction mechanism of the black TiO<SUB>2-x</SUB>/carbon nanofiber anode in the Na-ion cell operation is elucidated. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Single-Chip 마이크로 콘트롤러를 이용한 이상 전류 검출기

김경렬,나채동,문학룡,유두영 崇實大學校 生産技術硏究所 1993 論文集 Vol.23 No.-

The development of the measurement technology has occupied an important position of not only the electrical, electronic but also scientific technology sphere. In the past, the abnormal current detector was used by the analog method, had many the trouble and the inconvenience of measurement, dissatisfied the accuracy and had difficulty in storing, preserving the data. In this paper, these are improved by using single-chip microcontroller which detects the abnormal current and saves in back-up RAM after digitizing. For the efficient management, processing of the memory, it was used the index method. The data in the memory can be transmitted to the personal computer by the serial communication, and also be independently transmitted by the parallel communication to the personal computer which is interfaced with. The software to control system components are structured in assembly language and C language, in order to process and analyze the software is used in C language.

Caustic에서의 음장특성

김두현,나정열 한양대학교 이학기술연구소 2000 이학기술연구지 Vol.2 No.

실제 해양에서 동일한 수심과 거리에서 둘 이상의 음선이 교차하여 형성되는 Caustic에서는 무한대의 음압을 나타내는 이론과는 달리 주변지역과 비교하여 비슷하거나 다소 높은 정도의 음압을 나타낸다. 모델에서는 여러 가지 approximation을 이용하여 caustic에서의 음압을 계산하고 있다. 음선 모델(ray model)에서 계산되는 caustic에서의 음압은 causic에 의한 -π/2만큼의 위상변화는 caustic위치에서의 음압뿐만 아니라 그 이후 지역의 음압에도 영향을 미친다. caustic에 의한 위상변화를 고려한 경우의 음압은 위상변화를 고려하지 않은 경우의 음압과 비교하여 증감을 반복하였다. 따라서 incoherent propagation loss가 coherent propagation loss의 거리에 따른 평균값과 유사한 값을 나타냄을 고려하면 caustic위치에서 incoherent summation을 이용한 전달손실 계산이 가능함을 알 수 있다. In the real ocean, contrary to a theory, pressure at caustic which means a place that more than two rays cross on very close time is similar to near caustic region. Ray model calculates this pressure by using lots of approximation method. Because pressure at caustic is approximated through phase shift of ray which touch the caustic as much as -π/2 on the ray which already have passed through a caustic are affect not only pressure of caustic birthplace but also pressure of behind of caustic birthplace. At caustic birthplace pressure which considered phase shift due to caustic is fluctuated compare with that unconsidered phase shift. So, if we consider that incoherent propagation loss is close to range averaged coherent propagation loss, incoherent summation can be used to calculate a propagation loss even at a caustic birthplace.

사무직 근로자의 경력개발 지원 현황 및 요구 분석 : 중소기업과 대기업의 비교를 중심으로

이찬,정철영,나승일,김진모,강두천 한국농업교육학회 2008 농업교육과 인적자원개발 Vol.40 No.2

이 연구의 목적은 우리나라 대기업 및 중소기업의 사무직 근로자 경력개발 지원 현황 및 교육 요구를 분석하고 경력개발 지원의 필요성 및 시사점을 도출하는데 있다. 따라서, 기업체 인사교육담당지들을 대상으로 사무직 근로자 직무교육 현황, 사무직 근로자의 역량수준 및 요구, 직무교육이 필요한 사무직의 업무활동분야 국가차원에서의 시무직 분야별 교육과정 개발 요구 등에 대한 요구분석을 실시하였다. 구체적인 연구 결과는 다음과 같다. 첫째, 대부분의 기업은 전문역량을 보유한 근로자를 선호하는 것으로 나타났다. 둘째, 사무직 근로자의 경우 직위가 올라갈수록 전문가 수준에 근접한 직무역량이 필요한 것으로 나타났다. 셋째, 전체 응답기업의 74.9%가 직무교육을 실시하고 있다고 응답하였고 근로자 1인당 연평균 직무교육 시간은 49시간으로 나타났다. 넷째, 전체 응답기업의 64.8%는 외부 위탁교육을 실시하는 것으로 나타났으며, 특히 중소기업이 대기업에 비해 위탁교육 의존도가 더 높은 것으로 드러났다. 다섯째, 승계계획(succession plan)은 전체 응답기업의 25.7%만이 도입 · 운영하고 있는 것으로 나타났다. 여섯째, 국가가 사무직 근로자의 직무능력 향상을 위해 교육과정을 개발하는 것에 대해서는 전체 응답기업의 69.7%가 긍정적으로 인식하였고, 가장 우선적으로 개발해야 할 교육과정으로는 전체 응답기업의 60.8%가 인사 · 노무 분야를 선정하였다. 마지막으로, 국가가 사무직 근로자를 대상으로 한 교육과정을 개발할 경우 전체 응답기업의 58.5%가 해당 교육과정에 근로자를 참여시킬 것이라고 응답하였다. 이를 통하여 ①사무직 근로자들의 일반역량과 전문역량을 모두 강화할 수 있는 전략적 접근의 필요성,②중소기업을 중심으로 사무직 근로자의 직무역량을 강화할 수 있는 직무 교육 확대 및 지원방안 요구, ③경력개발제도의 도입 · 운영의 필요성, ④국가가 가장 우선적으로 개발해야할 교육과정으로 도출된 인사 · 노무, 마케팅, 회계 분야에 있어서는 직무분석, 환경분석, 학습과제 분석 등의 실시를 제언하였다. The purpose of this study was to analyze training needs and current situation of career development of office workers in small-medium sized enterprises and large corporations to find initiatives for supporting career development in Korea. The survey was conducted to HR practitioners in small-medium sized enterprises and large corporations about training situation of office workers, competency level of office workers, areas in need of training, and needs of curriculum development from government subsidized programs. Findings from this study was as follows. First, most of the companies prefer workers with job professional competencies. Second, expert level job competency was required for office workers as they got promoted. Third, 74.9% of responding companies was conducting job training and average training hours per year for workers were 49 hours. Forth, 64.8% of responding companies was conducting outsourcing training. Especially for small and medium sized companies, they tended to more rely on outsourcing training. Fifth, only 25.7% of responding companies was conducting succession plan. Sixth, 69.7% of responding companies reacted positively about developing government-directed training program. Finally, if the Korean government develops training curriculum for office workers, 58.5% of the responding companies answered that they would have their employees take the training programs. In short, ① Needs of strategic approach for strengthening general competencies and professional competencies for office workers, ② Request of supporting policy for strengthening job competencies of office workers focusing on small and medium sized enterprises, ③ Neccessity of introduction and operation of career development system, ④ Operating task analysis, job analysis, environment analysis in the field of HR, Labor, Marketing, Accounting which needs to be developed in advance by the Korean government were suggested.

영아에서 발생한 골수섬유증 1례

최성민,이동석,권경배,김두권,김나연,원유흥,이준희,권영무 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

특발성 골수섬유증은 만성 골수증식성 질환의 하나로 말초혈액도말에서 백적아구증, 부동변형적혈구 눈물방울세포 소견을 보이며, 골수 생검상 망상 섬유와 교원섬유로 구성된 섬유조직이 증가하는 골수의 섬유화 소견을 보이며, 골수외 조혈작용으로 인한 대상적 비장·간장 종대를 특징으로 하는 소아에서는 극히 드문 질환이다. 저자들은 본원에 복부종괴와 안면창백으로 입원하였던 8개월된 남아에서 임상증상, 말초혈액검사, 골수생검에서 특발성 골수섬유증으로 진단되어 Methylprednisolone 대량 정주 요법으로 치료하였으나 진단7개월만에 패혈증과 심부전으로 사망했던 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Idiopathic myelofibrosis is a chronic myeloproliferative disorder characterized by anemia, leukoerythroblastosis, anisopoikilocytosis, tear-drop cell, extramedullary hematopoiesis with hepatosplenomegaly and varying degrees of myelofibrosis of bone marrow. The mean age is about 60 years, and pediatric cases are rare. We experienced a case of idiopathic myelofibrosis in a 8 months old male who was presented with pallor, huge splenomegaly, leukoerythroblastosis in peripheral blood, myelofibrosis in bone marrow biopsy. We presented a case of idiopathic myelofibrosis with brief review of the literatures.

메티실린 내성 황색 포도상구균에서 vancomycin과 gentamicin병용의 항균력 상승효과 : Gentamicin 감수성에 따른 영향

김양수,김은옥,이상오,김백남,류지소,배직현,우준희,김미나,정두련,박수진 대한감염학회 1998 감염 Vol.30 No.2

배 경 : Vancomycin은 메티실린 내성 황색 포도상구균(methicillin-resistant Staphylococcus aureus, MRSA) 감염치료 시 선택 약제이다. 그러나, MRSA에 의한 심내막염과 같은 심부감염에서는 vancomycin 단독치료로 실패하는 경우가 흔히 보고되고 있다. MRSA에서 vancomycin과 aminoglycoside 병용의 상승효과에 대하여는 기존의 연구가 많지 않았다. 따라서 본 연구에서는 MRSA에서 vancomycin과 gentamicin 병합 시 상승효과가존재하는지를 알아보고, 만일 상승효과가 있다면 이를 예측할 수 있는 gentamicin의 최소억제농도를 밝히고자 하였다. 방 법 : 임상검체로부터 분리된 MRSA균주 중 무작위로 51균주를 선택하여 한천 희석법으로 gentamicin에 대한 최소 억제농도를 측정하였다. 이들 중 다양한 최소억제농도를 가지는 25균주에 대하여 vancomicin에 대한 최소억제농도와 최소살균농도를 측정하여 vancomycin에 대한 내약성(tolerance)여부를 조사하였고, vancomicin과 gentamicin 단독 및 병합에 대한 "time-kill 연구"를 시행하였다. 결 과 : MRSA 51균주에 대한 gentamicin의 최소억제농도는 4μg/mL 이하에서 512μg/mL 이상의 범위였으며, 7균주(13.7%)에서 감수성을 보였고 나머지 44균주(86.3%)는 내성이었다. 선택된 25균주의 MRSA 모두가 vancomycin에 감수성을 보였으나 16균주(64.0%)는 vancomycin에 tolerance를 보였다. Time kill 측정에서 약물 상호 작용의 분석이 가능하였던 18균주 중 5균주(27.8%)에서 상승효과가 관찰되었으며 나머지 13균주(72.2%)는 상호 무관한 작용을 보였다. 상승효과를 보인 5균주 모두가 gentamicin 최소억제농도 32μg/mL 이하이었으며, gentamicin 최소억제농도가 64μg/mL 이상인 균주 중 상승 작용을 보인 균주는 없었다. 결 론 : 메티실린 내성 황색 포도상구균의 대부분은 gentamicin에 내성을 보이지만, gentamicin에 내성이 있는 경우라도 gentamicin 최소억제농도가 32μg/mL 이하라면 vancomicin과 gentamicin을 병합 치료하여 상승효과를 기대할 수 있을 것으로 생각된다. Background : Vancomycin is the drug of choice for the treatment of infections caused by methicillin-resistant Staphylococcus aureus(MRSA). However, vancomycin monotherapy of deep-seated staphylococcal infection may be associated with poor bacteriological response. Limited data suggest that vancomycin-gentamicin combination therapy is effective against MRSA. In this study, we evaluated the vancomycin-gentamicin synergism against MRSA and also investigated whether gentamicin susceptibility may affect the synergism. Materials and Methods : The 51 strains of MRSA were obtained from patients at the Asan Medical Center from 1995 to 1996. The minimal inhibitory concentrations(MICs) of gentamicin were determined by the agar dilution method. The 25 strains with various levels of gentamicin MICs were chosen for time-kill studies. The MICs and minimal bactericidal concentrations(MBCs) of vancomycin were defined to determine vancomycin tolerance. Time-kill curves were established with vancomycin, gentamicin, and a combination of both. Results : Gentamicin MICs ranged from 4 to 512 μg/mL. Only 7 of the 51 strains were gentamicin-susceptible and 44 were resistant. All of the 25 strains chosen were susceptible to vancomycin, but 16 of them showed tolerance. Vancomycin-gentamicin synergism was demonstrated in 5 of the 18 strains, in which the analysis of drug interaction was possible. In the remaining 13 strains, vancomycin and gentamicin interacted in a nonsynergistic manner. In all strains that showed synergism, the MICs of gentamicin were below 32 μg/mL. No synergism was demonstrated in strains with gentamicin MICs above 64 μg/mL. Conclusions : Although most of MRSA strains are resistant to gentamicin, synergistic interaction between vancomycin and gentamicin may be expected when the MIC of gentamicin is below 32 μg/mL.

Paeonol inhibits anaphylactic reaction by regulating histamine and TNE-α

Kim, Sung Hoon,Kim, Seung-Ae,Park, Mi-Kyung,Kim, Seung-Hyung,Park, Young-Doo,Na, Ho-Jeong,Kim, Hyung-Min,Shin, Min-Kyu,Ahn, Kyoo-Seok WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Paconol, a major phenolic component of Moutan Cortex, was known to have antiaggregatory, antioxidant and antiinflammatory activities. In the present study, we tried to elucidate thc effects of paconol on anaphylactic reaction and its mode of action. Paconol significantly inhibited histamine release from the rat peritoneal mast cells (RPMCs) treated with compound 48/80, a mast cell degranulator. The release of tumor necrosis factor (TNF)-α mast cell activating cytokine was significantly suppressed in RBL-2H3 mast cells pretreated with anti-dinitrophenyl (DNP) immunoglobulin E (lgE) in a dose-dependent manner. Paconol significantly inhibited lgE production in B cells activated by anti-CD40 mAb, recombinant interlcukin-4 (rIL-4) and recombinant histamine releasing factor (rHRF). Paconol effectively downregulated the expression of IL-4 in the activated B cells by reverse transcription polymerase chain reaction (RT- PCR). We also confirmed that paconol effectivcly inhibited anaphylactic shock in mice by 90% at a dose of 0.5 mg/mouse versus PBS treated control 2 h after the i.p. injection of compound 48/80. These results suggest that paconol has antianaphylatic activity by regulating histamine and TNF-α.

Influence of Local Myocardial Infarction on Endothelial Function, Neointimal Progression, and Inflammation in Target and Non-Target Vascular Territories in a Porcine Model of Acute Myocardial Infarction

Kim, Hyun Kuk,Kim, Han Byul,Lee, Joo Myung,Kim, Sung Soo,Bae, In Ho,Park, Dae Sung,Park, Jun-Kyu,Shim, Jae Won,Na, Joo-Young,Lee, Min Young,Kim, Joong Sun,Sim, Doo Sun,Hong, Young Joon,Nam, Chang-Wook KOREAN ACADEMY OF MEDICAL SCIENCE 2019 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.34 No.19

<P><B>Background</B></P><P>Patients with acute myocardial infarction (AMI) have worse clinical outcomes than those with stable coronary artery disease despite revascularization. Non-culprit lesions of AMI also involve more adverse cardiovascular events. This study aimed to investigate the influence of AMI on endothelial function, neointimal progression, and inflammation in target and non-target vessels.</P><P><B>Methods</B></P><P>In castrated male pigs, AMI was induced by balloon occlusion and reperfusion into the left anterior descending artery (LAD). Everolimus-eluting stents (EES) were implanted in the LAD and left circumflex (LCX) artery 2 days after AMI induction. In the control group, EES were implanted in the LAD and LCX in a similar fashion without AMI induction. Endothelial function was assessed using acetylcholine infusion before enrollment, after the AMI or sham operation, and at 1 month follow-up. A histological examination was conducted 1 month after stenting.</P><P><B>Results</B></P><P>A total of 10 pigs implanted with 20 EES in the LAD and LCX were included. Significant paradoxical vasoconstriction was assessed after acetylcholine challenge in the AMI group compared with the control group. In the histologic analysis, the AMI group showed a larger neointimal area and larger area of stenosis than the control group after EES implantation. Peri-strut inflammation and fibrin formation were significant in the AMI group without differences in injury score. The non-target vessel of the AMI also showed similar findings to the target vessel compared with the control group.</P><P><B>Conclusion</B></P><P>In the pig model, AMI events induced endothelial dysfunction, inflammation, and neointimal progression in the target and non-target vessels.</P>