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김우완,천희식,장상동 慶南大學校 附設 工業技術硏究所 2003 硏究論文集 Vol.21 No.1
멀티캐스트 및 실시간 오디오/비디오 스트리밍 어플리케이션과 같은 새로운 커뮤니케이션 트렌드로 인하여 인터넷상에서 non-TCP 트래픽이 증가하는 추세에 있다. 이러한 어플리케이션은 TCP-friendly기준에 따르는 혼잡 제어를 거의 수행하고 있지도 않으며, 유효 대역폭을 웹 브라우저, FTP, 이메일 클라이언트 등과 같이 TCP를 기반으로 하는 어플리케이션과 공평하게 공유하지도 않는다. 그러므로 지금과 같은 추세로 나아간다면 인터넷은 TCP 트래픽의 Starvation과 Congestion Collapse를 발생시킬 가능성이 높다. 이를 위해 TCP 플로우와의 공존을 지원하는 TCP-friendly프로토콜이 개발되고 있다. 본 논문에서는 TCP friendliness를 위한 현재의 접근 방법을 살펴보고, 각각의 특징을 알아보기로 한다. 그리고 유니캐스트 및 멀티캐스트에 관한 여러 혼잡 제어 프로토콜을 상세히 살펴보기로 한다. Non-TCP traffic on the Internet is on an increasing trend due to new communication patterns such as multicast and real-time audio/video streaming applications. These applications inherently do not perform congestion control in accordance with TCP-friendly standard criteria, nor share valid bandwidth with TCP-based applications like Web Browsers, FTP. E-mail Clients, etc. This means that current drift on the Internet may produce a high possibility of starvation and congestion collapse of TCP traffic. To deal with the unwanted situation such as congestion collapse and starvation, many TCP-friendly protocols supporting non-TCP flows in keeping pace with TCP ones are proposed and still being developed. This paper comprehensively surveys current approaches to TCP-friendliness and their properties in detail in order to systematically aid researches in TCP congestion controls that are the subject of wide attention.
DAB Converter Based on Unified High-Frequency Bipolar Buck-Boost Theory for Low Current Stress
Jia-rong Kan,Yao-dong Yang,Yu Tang,Dong-chun Wu,Yun-ya Wu,Jiang Wu 전력전자학회 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.2
This paper proposes a unified high-frequency bipolar buck-boost (UHFBB) control strategy for a dual-active-bridge (DAB), which is derived from the classical buck and boost DC/DC converter. It can achieve optimized current stress of the switches and soft switching in wider range. The UHFBB control strategy includes multi-control-variables, which can be achieved according to an algorithm derived from an accurate mathematical model. The design method for the parameters, such as the transformer turns ratio and the inductance, are shown. The current stress of the switches is analyzed for selecting an optimal inductor. The analysis is verified by the experimental results within a 500W prototype.
DAB Converter Based on Unified High-Frequency Bipolar Buck-Boost Theory for Low Current Stress
Kan, Jia-rong,Yang, Yao-dong,Tang, Yu,Wu, Dong-chun,Wu, Yun-ya,Wu, Jiang The Korean Institute of Power Electronics 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.2
This paper proposes a unified high-frequency bipolar buck-boost (UHFBB) control strategy for a dual-active-bridge (DAB), which is derived from the classical buck and boost DC/DC converter. It can achieve optimized current stress of the switches and soft switching in wider range. The UHFBB control strategy includes multi-control-variables, which can be achieved according to an algorithm derived from an accurate mathematical model. The design method for the parameters, such as the transformer turns ratio and the inductance, are shown. The current stress of the switches is analyzed for selecting an optimal inductor. The analysis is verified by the experimental results within a 500W prototype.
Dong, Wei-Wei,Zhao, Jinhua,Zhong, Fei-Liang,Zhu, Wen-Jing,Jiang, Jun,Wu, Songquan,Yang, Deok-Chun,Li, Donghao,Quan, Lin-Hu The Korean Society of Ginseng 2017 Journal of Ginseng Research Vol.41 No.4
Background: In general, after Panax ginseng is administered orally, intestinal microbes play a crucial role in its degradation and metabolization process. Studies on the metabolism of P. ginseng by microflora are important for obtaining a better understanding of their biological effects. Methods: In vitro biotransformation of P. ginseng extract by rat intestinal microflora was investigated at $37^{\circ}C$ for 24 h, and the simultaneous determination of the metabolites and metabolic profile of P. ginseng saponins by rat intestinal microflora was achieved using LC-MS/MS. Results: A total of seven ginsenosides were detected in the P. ginseng extract, including ginsenosides Rg1, Re, Rf, Rb1, Rc, Rb2, and Rd. In the transformed P. ginseng samples, considerable amounts of deglycosylated metabolite compound K and Rh1 were detected. In addition, minimal amounts of deglycosylated metabolites (ginsenosides Rg2, F1, F2, Rg3, and protopanaxatriol-type ginsenosides) and untransformed ginsenosides Re, Rg1, and Rd were detected at 24 h. The results indicated that the primary metabolites are compound K and Rh1, and the protopanaxadiol-type ginsenosides were more easily metabolized than protopanaxatriol-type ginsenosides. Conclusion: This is the first report of the identification and quantification of the metabolism and metabolic profile of P. ginseng extract in rat intestinal microflora using LC-MS/MS. The current study provided new insights for studying the metabolism and active metabolites of P. ginseng.
Wu, Dong-Ming,Zhang, Peng,Xu, Guang-Chao,Tong, Ai-Ping,Zhou, Cong,Lang, Jin-Yi,Wang, Chun-Ting Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4
Pemetrexed is an antifolate agent which has been used for treating malignant pleural mesothelioma and non small lung cancer in the clinic as a chemotherapeutic agent. In this study, pemetrexed inhibited cell growth and induced G1 phase arrest in the A549 cell line. To explore the molecular mechanisms of pemetrexed involved in cell growth, we used a two-dimensional polyacrylamide gel electrophoresis (2-DE) proteomics approach to analyze proteins changed in A549 cells treated with pemetrexed. As a result, twenty differentially expressed proteins were identified by ESI-Q-TOF MS/MS analysis in A549 cells incubated with pemetrexed compared with non-treated A549 cells. Three key proteins (GAPDH, HSPB1 and EIF4E) changed in pemetrexed treated A549 cells were validated by Western blotting. Accumulation of GAPDH and decrease of HSPB1 and EIF4E which induce apoptosis through inhibiting phosphorylation of Akt were noted. Expression of p-Akt in A549 cells treated with pemetrexed was reduced. Thus, pemetrexed induced apoptosis in A549 cells through inhibiting the Akt pathway.
( Chih Chun Hsieh ),( Dong Yih Lin ),( Wei Te Wu ) 대한금속재료학회 ( 구 대한금속학회 ) 2007 METALS AND MATERIALS International Vol.13 No.5
The dispersion strengthening behavior of the σ phase in 304 modified stainless steel as hot-rolled at 1073 K has been investigated in this study. The morphology, quantity and chemical composition of the σ phase were analyzed using optical microscopy (OM), X-ray diffractometry (XRD), ferritscope (FS), and image analysis (IA). The amounts of σ phase in the stainless steels increased gradually at 1073 K as the reduction ratio increased from 0% to 75%. The XRD analyses showed that a higher reduction ratio enhanced the conversion of δ-ferrite (110) to σ phase (542). The σ phase was precipitated homogeneously at the recrystallized ferrite grains when the reduction ratio was increased from 0% to 75%.
Wen, Chun-Jie,Wu, Lan-Xiang,Fu, Li-Juan,Shen, Dong-Ya,Zhang, Xue,Zhang, Yi-Wen,Yu, Jing,Zhou, Hong-Hao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Estrogens are considered the major breast cancer risk factor, and the carcinogenic potential of estrogens might be attributed to DNA modification caused by derivatives formed during metabolism. $17{\beta}$-estradiol ($E_2$), the main steroidal estrogen present in women, is metabolized via two major pathways: formation of 2-hydroxyestradiol (2-OH $E_2$) and 4-hydroxyestradiol ($4-OH\;E_2$) through the action of cytochrome P450 (CYP) 1A1 and 1B1, respectively. Previous reports suggested that $2-OH\;E_2$ has putative protective effects, while $4-OH\;E_2$ is genotoxic and has potent carcinogenic activity. Thus, the ratio of $2-OH\;E_2/4-OH\;E_2$ is a critical determinant of the toxicity of $E_2$ in mammary cells. In the present study, we investigated the effects of berberine on the expression profile of the estrogen metabolizing enzymes CYP1A1 and CYP1B1 in breast cancer MCF-7 cells. Berberine treatment produced significant induction of both forms at the level of mRNA expression, but with increased doses produced 16~ to 52~fold greater induction of CYP1A1 mRNA over CYP1B1 mRNA. Furthermore, berberine dramatically increased CYP1A1 protein levels but did not influence CYP1B1 protein levels in MCF-7 cells. In conclusion, we present the first report to show that berberine may provide protection against breast cancer by altering the ratio of CYP1A1/CYP1B1, could redirect $E_2$ metabolism in a more protective pathway in breast cancer MCF-7 cells.
( Chih Chun Hsieh ),( Tao Chih Chang ),( Dong Yih Lin ),( Ming Che Chen ),( Wei Te Wu ) 대한금속재료학회 ( 구 대한금속학회 ) 2007 METALS AND MATERIALS International Vol.13 No.5
The purpose of this study is to investigate the precipitation characteristics of σ phase in the fusion zone of stainless steel welds at various welding passes during a tungsten arc welding (GTAW) process. The morphology, quantity, and chemical composition of the δ-ferrite and σ phase were analyzed using optical microscopy (OM), a ferritscope (FS), a X-ray diffractometer (XRD), scanning electron microscopy (SEM), an electron probe micro-analyzer (EPMA), and a wavelength dispersive spectrometer (WDS), respectively. Massive δ-ferrite was observed in the fusion zone of the first pass welds during welding of dissimilar stainless steels. The σ phase precipitated at the inner δ-ferrite particles and decreased δ-ferrite content during the third pass welding. The σ and δ phases can be stabilized by Si element, which promoted the phase transformation of δ→σ + γ2 in the fusion zone of the third pass welds. It was found that the σ phase was a Fe-Cr-Si intermetallic compound found in the fusion zone of the third pass welds during multi-pass welding.