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RISS 인기검색어
- 검색키워드
- 저자 : Dhivakar, Mani (검색결과 2 건)
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Rathika, Chinniah,Murali, Vijayan,Dhivakar, Mani,Kamaraj, Raju,Malini, Ravi Padma,Ramgopal, Sivanadham,Balakrishnan, Karuppiah Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.5
Background: Human leukocyte antigen (HLA) genes have been implicated in cervical cancer in several populations. Objectives: To study the predispositions of HLA alleles/haplotypes with cervical cancer. Materials and Methods: Clinically diagnosed and PAP smear confirmed cervical cancer patients (n 48) and age matched controls (n 47) were genotyped for HLA-A,-B,-DRB1* and DQB1* alleles by PCR-SSP methods. Results: The frequencies of alleles DRB1*04 (OR=2.57), DRB1*15 (OR=2.04), DQB1*0301 (OR=4.91), DQB1*0601 (OR=2.21), B*15 (OR=13.03) and B*07 (OR=6.23) were higher in cervical cancer patients than in the controls. The frequencies of alleles DRB1*10 (OR=0.22) and B*35 (OR=0.19) were decreased. Strong disease associations were observed for haplotypes DRB1*15-DQB1*0601 (OR=6.56; p< $3.5{\times}10^{-4}$), DRB1*14-DQB1*0501 (OR=6.51; p<0.039) and A*11-B*07 (OR=3.95; p<0.005). The reduced frequencies of haplotypes DRB1*10-DQB1*0501 (OR=0.45), A*03-B*35 (OR=0.25) and A*11-B*35 (OR= 0.06) among patients suggested a protective association. HLA-C* typing of 8 patients who possessed a unique three locus haplotype 'A*11-B*07-DRB1*04' (8/48; 16.66%; OR=6.51; p<0.039) revealed the presence of a four locus haplotype 'A*11-B*07-C*01-DRB1*04' in patients (4/8; 50%). Amino acid variation analysis of susceptible allele DQB1*0601 suggested 'tyrosine' at positions ${\beta}9$ and ${\beta}37$ and tyrosine-non-tyrosine genotype combination increased the risk of cervical cancer. Conclusions: Strong susceptible associations were documented for HLA alleles B*15, B*07, DRB1*04, DRB1*15, DQB1*0301, DQB1*0601 and haplotypes DRB1*15-DQB1*0601 and DRB1*14-DQB1*0501. Further, protective associations were evidenced for alleles B*35 and DRB1*10 and haplotypes A*11-B*35 and DRB1*10-DQB1*0501 with cervical cancer in South India.
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K. Yuvaraj,M. Sakthivel,M. Dhivakar Karthick,T. Pradeep,M. Veerapathran,S. Gowtham 한양대학교 청정에너지연구소 2024 Journal of Ceramic Processing Research Vol.25 No.2
An attempt was undertaken to elevate the efficacy of Engineered Cementitious Composites (ECC) mixes by inclusion ofsilica fume alongside mono fiber and hybrid fiber in this study. Totally, six mixes were prepared with low modulus and highmodulus fiber. The initial three mixtures consist of mono fiber engineered cementitious composites (MFECC), incorporatingPoly Vinyl Alcohol (PVA), Polypropylene (PP), and Glass fiber, each with a 2% volume fraction. The remaining three mixtureswere formulated as hybrid fiber engineered cementitious composites (HFECC), combining PVA (1%) and PP (1%), PP (1%)and Glass (1%), and lastly, PVA (1%) and Glass (1%). In addition, all six mixtures were consistently maintained with a fixedcomposition comprising 40% silica fume, 30% fly ash, 80% M-sand, a water-to-binder ratio of 0.35, and 1% superplasticizer. The findings suggest that within the examined compositions, MFECC reinforced with 2.0% PVA fiber and HFECC reinforcedwith 1% PVA fiber and 1% glass fiber exhibit more significant strength characteristics than other mixtures.
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