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Deyu Li,Qin Tong,Yuane Lian,Zhizhong Chen,Yaru Zhu,Weimei Huang,Yang Wen,Qiongyao Wang,Shumei Liang,Man Li,Jianjing Zheng,Zhenhua Liu,Huanxin Liu,Linlang Guo 대한암학회 2021 Cancer Research and Treatment Vol.53 No.4
Purpose Drug resistance is one of the main causes of chemotherapy failure in patients with small cell lung cancer (SCLC), and extensive biological studies into chemotherapy drug resistance are required. Materials and Methods In this study, we performed lncRNA microarray, in vitro functional assays, in vivo models and cDNA microarray to evaluate the impact of lncRNA in SCLC chemoresistance. Results The results showed that KCNQ1OT1 expression was upregulated in SCLC tissues and was a poor prognostic factor for patients with SCLC. Knockdown of KCNQ1OT1 inhibited cell proliferation, migration, chemoresistance and promoted apoptosis of SCLC cells. Mechanistic investigation showed that KCNQ1OT1 can activate transforming growth factor-β1 mediated epithelial-to-mesenchymal transition in SCLC cells. Conclusion Taken together, our study revealed the role of KCNQ1OT1 in the progression and chemoresistance of SCLC, and suggested KCNQ1OT1 as a potential diagnostic and prognostic biomarker in SCLC clinical management.
Analytical and numerical analysis for unbonded flexible risers under axisymmetric loads
Guo, Yousong,Chen, Xiqia,Wang, Deyu Techno-Press 2016 Ocean systems engineering Vol.6 No.2
Due to the structural complexity, the response of a flexible riser under axisymmetric loads is quite difficult to determine. Based on equilibrium conditions, geometrical relations and constitutive equations, an analytical model that can accurately predict the axisymmetric behavior of flexible risers is deduced in this paper. Since the mutual exclusion between the contact pressure and interlayer gap is considered in this model, the influence of the load direction on the structural behavior can be analyzed. Meanwhile, a detailed finite element analysis for unbonded flexible risers is conducted. Based on the analytical and numerical models, the structural response of a typical flexible riser under tension, torsion, internal and outer pressure has been studied in detail. The results are compared with experimental data obtained from the literature, and good agreement is found. Studies have shown that the proposed analytical and numerical models can provide an insightful reference for analysis and design of flexible risers.
Lewen Zhang,Deyu Guo,Jing Wu 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.8
The stability of the rocky slope is a systematic problem under the combined action of many complex and changeable factors. In this paper, a comprehensive evaluation model based on VIKOR and binary semantics is proposed, and the stability of the rocky slope is predicted and evaluated. Fristly, according to the damage mechanism and the failure process of the slope rock mass, eight influence factors, such as rock cohesion, internal friction angle, and seismic intensity, are selected as the evaluation indexes for the rocky slope stability forecast. The rocky slope stability evaluation index system has been established. Secondly, a stability forecast model of the rocky slope based on VIKOR and the binary semantics method is proposed. The visualization window and the software system of the prediction model are realized by the Python 3.5 software. Finally, the software is applied to the stability evaluation of the rocky slopes, such as Jinping I Hydropower Station and Longtan Hydropower Station. The result shows that: 1) The visual window and the software operating system of the rocky slope stability forecast model, as well as the evaluation index system replacement button are realized, which improve the calculation efficiency of the sample data and the practicability and applicability of the software system. 2) The calculation results of the rocky slope stability prediction model based on VIKOR and the binary semantics method proposed in this paper are more consistent with the actual engineering situation, and more accurate than the prediction results obtained by other evaluation methods. 3) The proposed software system of the rocky slope stability is also suitable for other geotechnical engineering such as tunnels and coal mines, and which has a good prospect of the engineering application.