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Antimicrobial and Cytotoxic Activity of Endophytic Fungi from Lagopsis supina
Zhang Dekui,Sun Weijian,Xu Wenjie,Ji Changbo,Zhou Yang,Sun Jingyi,Tian Yutong,Li Yanling,Zhao Fengchun,Tian Yuan 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.4
In this study, five endophytic fungi belonging to the Aspergillus and Alternaria genera were isolated from Lagopsis supina. The antimicrobial activity of all fungal fermented extracts against Staphylococcus and Fusarium graminearum was tested using the cup-plate method. Among them, Aspergillus ochraceus XZC-1 showed the best activity and was subsequently selected for large-scale fermentation and bioactivity-directed separation of the secondary metabolites. Four compounds, including 2- methoxy-6-methyl-1,4-benzoquinone (1), 3,5-dihydroxytoluene (2), oleic acid (3), and penicillic acid (4) were discovered. Here, compounds 1 and 4 displayed anti-fungal activity against F. graminearum, F. oxysporum, F. moniliforme, F. stratum, Botrytis cinerea, Magnaporthe oryzae, and Verticillium dahliae with diverse MIC values (128–512 μg/ml), which were close to that of the positive control antifungal, actidione (64–128 μg/ml). Additionally, compounds 1 and 4 also exhibited moderate antibacterial activity against S. aureus, Listeria monocytogenes, Escherichia coli, and Salmonella enterica, with low MIC values (8–64 μg/ml). Moreover, compounds 1 and 4 displayed selective cytotoxicity against cancer cell lines as compared with the normal fibroblast cells. Therefore, this study proposes that the endophytic fungi from L. supina can potentially produce bioactive molecules to be used as lead compounds in drugs or agricultural antibiotics.
Qianqian Guo,Wen Jing,Shangzeng Cheng,Zhanggen Huang,Dekui Sun,Yaqin Hou,Xiaojin Han 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.11
To determine the role of sulfur groups formed on activated carbon (AC) in the selective catalytic reduction (SCR) of NO with NH3, coal-based AC was modified by H2SO4 under various conditions and then treated in N2 atmosphere at 400 oC. The resulting carbons were characterized by N2 adsorption, elemental analysis, temperature programmed desorption and X-ray photoelectron spectroscopy, and tested for the SCR of NO with NH3 in the temperature range of 30-250 oC. Results reveal that H2SO4 modification has little effect on the textural properties, but promotes the formation of sulfur and oxygen groups. The sulfur groups incorporated by H2SO4 modification are mainly sulfonic groups and then sulfates. In particular, these sulfur groups play a predominant role in improving NH3 adsorption and then enhancing the SCR activity of modified carbons above 150 oC. However, the contribution of oxygen groups to NO reduction is very limited under the conditions employed in this work.