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- 저자 : David Issadore (검색결과 2 건)
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Recent developments in scale-up of microfluidic emulsion generation via parallelization
Daeyeon Lee,Heon-Ho Jeong,David Issadore 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.6
Microfluidics affords precise control over the flow of multiphasic fluids in micron-scale channels. By manipulating the viscous and surface tension forces present in multiphasic flows in microfluidic channels, it is possible to produce highly uniform emulsion droplets one at a time. Monodisperse droplets generated based on microfluidics are useful templates for producing uniform microcapsules and microparticles for encapsulation and delivery of active ingredients as well as living cells. Also, droplet microfluidics have been extensively exploited as a means to enable highthroughput biological screening and assays. Despite the promise droplet-based microfluidics hold for a wide range of applications, low production rate (<<10mL/hour) of emulsion droplets has been a major hindrance to widespread utilization at the industrial and commercial scale. Several reports have recently shown that one way to overcome this challenge and enable mass production of microfluidic droplets is to parallelize droplet generation, by incorporating a large number of droplet generation units (N>>100) and networks of fluid channels that distribute fluid to each of these generators onto a single chip. To parallelize droplet generation and, at the same time, maintain high uniformity of emulsion droplets, several considerations have to be made including the design of channel geometries to ensure even distribution of fluids to each droplet generator, methods for large-scale and uniform fabrication of microchannels, device materials for mechanically robust operation to withstand high-pressure injection, and development of commercially feasible fabrication techniques for three-dimensional microfluidic devices. We highlight some of the recent advances in the mass production of highly uniform microfluidics droplets via parallelization and discuss outstanding issues.
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Jeong, Heon-Ho,Han, Syung Hun,Yadavali, Sagar,Kim, Junhyong,Issadore, David,Lee, Daeyeon American Chemical Society 2018 Chemistry of materials Vol.30 No.8
<P>Soft lithography-based droplet microfluidics has enabled production of highly uniform and complex emulsions. Although there is a significant potential to use these emulsions as templates for functional materials syntheses, conventional elastomers that are used for microfluidic device preparation are significantly deformed and swollen by various organic solvents, limiting the types of materials that can be processed using conventional soft lithography-based droplet microfluidics. In this report, we demonstrate that both water-in-oil and oil-in-water emulsion with organic solvents can be produced by using microfluidic devices that are prepared using cross-linked networks of perfluoropolyether (PFPE) and poly(ethylene glycol) diacrylate (PEGDA). We show that these PFPE-PEG networks are transparent and maintain excellent compatibility with various organic solvents. Importantly, the wettability of these devices can be systematically controlled by changing the ratio of the two macromonomers. By taking advantage of rapid prototyping and controlled surface wettability afforded by the PFPE-PEG network, we prepare three-dimensional monolithic elastomer devices for the parallel generation of oil-in-water and water-in-oil droplets. We also show that, using these devices, solid microparticles with high uniformity can be produced by using an organic solvent-based emulsion as a template. We believe the PFPE-PEG network will have broad impacts in the application of soft lithography-based elastomer microfluidic devices to a wide range of applications, including drug screening and solvent-based separation processes.</P> [FIG OMISSION]</BR>
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