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Flt3 Signaling-Dependent Dendritic Cells Protect against Atherosclerosis
Choi, J.H.,Cheong, C.,Dandamudi, Durga B.,Park, C.,Rodriguez, A.,Mehandru, S.,Velinzon, K.,Jung, I.H.,Yoo, J.Y.,Oh, G.,Steinman, Ralph M. Cell Press 2011 Immunity Vol.35 No.5
Early events in atherosclerosis occur in the aortic intima and involve monocytes that become macrophages. We looked for these cells in the steady state adult mouse aorta, and surprisingly, we found a dominance of dendritic cells (DCs) in the intima. In contrast to aortic adventitial macrophages, CD11c<SUP>+</SUP>MHC II<SUP>hi</SUP> DCs were poorly phagocytic but were immune stimulatory. DCs were of two types primarily: classical Flt3-Flt3L signaling-dependent, CD103<SUP>+</SUP>CD11b<SUP>-</SUP> DCs and macrophage-colony stimulating factor (M-CSF)-dependent, CD14<SUP>+</SUP>CD11b<SUP>+</SUP>DC-SIGN<SUP>+</SUP> monocyte-derived DCs. Both types expanded during atherosclerosis. By crossing Flt3<SUP>-/-</SUP> to Ldlr<SUP>-/-</SUP> atherosclerosis-prone mice, we developed a selective and marked deficiency of classical CD103<SUP>+</SUP> aortic DCs, and they were associated with exacerbated atherosclerosis without alterations in blood lipids. Concomitantly, the Flt3<SUP>-/-</SUP>Ldlr<SUP>-/-</SUP> mice had fewer Foxp3<SUP>+</SUP> Treg cells and increased inflammatory cytokine mRNAs in the aorta. Therefore, functional DCs are dominant in normal aortic intima and, in contrast to macrophages, CD103<SUP>+</SUP> classical DCs are associated with atherosclerosis protection.
Melwani, Anjana M,Srinivasan, Ila,Setty, Jyothsna V,Murali, Krishna D.R.,Pamnani, Sunaina S,Lalitya, Dandamudi The Korean Dental Society of Anesthsiology 2018 Journal of Dental Anesthesia and Pain Medicine Vol.18 No.1
Background: The sight of dental injection can bring about severe anxiety in children. Therefore, an alternative method that is convenient, effective, and keeps the needle hidden making it child friendly is necessary. The objective of the study was to compare the efficacy of a camouflaged syringe and conventional syringe on behavior and anxiety in 6-11-year-old children during local anesthesia administration. Methods: The study was a randomized, crossover clinical study including 30 children. Children were separated into two groups. Group 1 consisted of 15 children aged 6-8 years while group 2 consisted of 15 children aged 9-11 years. This study involved two sessions wherein all the children were injected using conventional and camouflaged syringes in separate sessions. Their behavior was assessed using the Faces, Legs, Activity, Cry, Consolability (FLACC) behavior pain scale and anxiety was assessed by measuring changes in pulse rate. Patient and operator preferences were compared. Results: The results showed a lower mean change in pulse rate and FLACC scores in the camouflaged group, suggesting a positive behavior and lesser anxiety with camouflaged syringes than with conventional syringes. Conclusions: The use of camouflaged syringes for anesthesia was demonstrated to be effective in improving the behavior of children and decreasing their anxiety, and is therefore recommended as an alternative to the use of conventional syringes for local anesthesia.
Design, synthesis and biological studies of tetrazole fused imidazopyridines
Reddy Banoth,Taneja Amit Kumar,Tej Mandava Bhuvan,Navya Sri Komati,Tej Mandava Bhagya,Vijayavardhini Suryadevara,Srilaxmi Dandamudi,Tiruveedhula Somasekhar,Penumutchu Srinivasa Rao,Rao Mandava V. Basa 한국탄소학회 2024 Carbon Letters Vol.34 No.1
New tetrazole fused imidazopyridine derivatives (12a–j) were developed to exploit their cytotoxic activity towards cancer cell lines-MCF7, A549, and MDA-MB-231, utilizing MTT reduction assay with doxorubicin as standard drug. The compounds 12 h and 12j demonstrated strong anticancer activity bearing IC50 values 1.44 µM and 1.33 µM against A549 cell line.
Cheong, Cheolho,Choi, Jae-Hoon,Vitale, Laura,He, Li-Zhen,Trumpfheller, Christine,Bozzacco, Leonia,Do, Yoonkyung,Nchinda, Godwin,Park, Sung Ho,Dandamudi, Durga Bhavani,Shrestha, Elina,Pack, Maggi,Lee, American Society of Hematology 2010 Blood Vol.116 No.19
<B>Abstract</B><P>Protein vaccines for T-cell immunity are not being prioritized because of poor immunogenicity. To overcome this hurdle, proteins are being targeted to maturing dendritic cells (DCs) within monoclonal antibodies (mAbs) to DC receptors. To extend the concept to humans, we immunized human immunoglobulin-expressing mice with human DEC205 (hDEC205) extracellular domain. 3D6 and 3G9 mAbs were selected for high-affinity binding to hDEC205. In addition, CD11c promoter hDEC205 transgenic mice were generated, and 3G9 was selectively targeted to DCs in these animals. When mAb heavy chain was engineered to express HIV Gag p24, the fusion mAb induced interferon-γ- and interleukin-2-producing CD4+ T cells in hDEC205 transgenic mice, if polynocinic polycytidylic acid was coadministered as an adjuvant. The T-cell response was broad, recognizing at least 3 Gag peptides, and high titers of anti-human immunoglobulin G antibody were made. Anti-hDEC205 also improved the cross-presentation of Gag to primed CD8+ T cells from HIV-infected individuals. In all tests, 3D6 and 3G9 targeting greatly enhanced immunization relative to nonbinding control mAb. These results provide preclinical evidence that in vivo hDEC205 targeting increases the efficiency with which proteins elicit specific immunity, setting the stage for proof-of-concept studies of these new protein vaccines in human subjects.</P>