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- 저자 : Creran, Brian (검색결과 1 건)
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Regulating exocytosis of nanoparticles <i>via</i> host–guest chemistry
Kim, Chaekyu,Tonga, Gulen Yesilbag,Yan, Bo,Kim, Chang Soo,Kim, Sung Tae,Park, Myoung-Hwan,Zhu, Zhengjiang,Duncan, Bradley,Creran, Brian,Rotello, Vincent M. The Royal Society of Chemistry 2015 Organic & Biomolecular Chemistry Vol.13 No.8
<P>Prolonged retention of internalized nanoparticulate systems inside cells improves their efficacy in imaging, drug delivery, and theranostic applications. Especially, regulating exocytosis of the nanoparticles is a key factor in the fabrication of effective nanocarriers for chemotherapeutic treatments but orthogonal control of exocytosis in the cellular environment is a major challenge. Herein, we present the first example of regulating exocytosis of gold nanoparticles (AuNPs), a model drug carrier, by using a simple host–guest supramolecular system. AuNPs featuring quaternary amine head groups were internalized into the cells through endocytosis. Subsequent <I>in situ</I> treatment of a complementary cucurbit[7]uril (CB[7]) to the amine head groups resulted in the AuNP-CB[7] complexation inside cells, rendering particle assembly. This complexation induced larger particle assemblies that remained sequestered in the endosomes, inhibiting exocytosis of the particles without any observed cytotoxicity.</P> <P>Graphic Abstract</P><P>Regulating exocytosis of AuNPs by using host–guest interactions between AuNPs and CB[7] molecules. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4ob02433h'> </P>
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