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Study of national laboratory animal program on out-of-the way laboratory animal resources
Chuel kyu Kim,Dae Youn Hwang,Byoung Guk Kim,Yong Kyu Kim,Sun Bo Shim,Seung Wan Jee,Su Hae Lee,Ji Soon Sin,Chang Jun Bae,Byoung Chun Lee,Jung Sik Cho,Kap Ryong Chae,Hyoung Jin Kim,Byoung Chue Kim 한국실험동물학회 2007 한국실험동물학회 학술발표대회 논문집 Vol.2007 No.-
Four-Week Repeated-Dose Toxicity Study of Di-isodecyl Phthalate (DIDP) in Ras H2 Wild Type Mice
Chuel Kyu Kim,Beom Seok Han,Jae Ho Oh,Wan-Seob Cho,Ki Dae Park,Mina Choi,Min Jung Cho,Sang Yeon Oh,Sung Jun Kim,Ja Young Jeong,Seung Hee Kim,Dong Deuk Jang 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.3
Di-isodecyl phthalate (DIDP) has widely used as plasticizer in polyvinyl chloride (PVC) manufacture and ultimately typical vinyl applications, particularly wire, cable and toys. To determine dose selection of DIDP for alternative carcinogenicity study using ras H2 transgenic mice, we conducted four week repeated toxicity study with ras H2 wild type mice. Groups of 8 male and female ras H2 wild type mice were fed basal diet containing DIDP at doses of 0, 0.1, 0.3, 1, and 3% for 4 weeks. Decreases of motility and mortality were increased in the 3% DIDP treatment group. The body weights of 3% DIDP treatment group were significantly decreased compared to those of control group. The relative liver weights of male and female mice given 0.3 and 1% DIDP were significantly increased compared to those of control. At necropsy, there were no significant changes in gross lesions between treatment and control group. Microscopically, the incidences of hypertrophy of liver in mice exposed to 1 and 3% DIDP treatment groups were increased. These results indicate that DIDP has liver toxicity at greater than 1% dose. Therefore, maximum tolerated dose (MTD) was determined for each biological endpoints at a dietary level of 1%.
Chuel Kyu Kim,Dae Youn Hwang,Byoung Guk Kim,Seung Wan Jee,Yong Kyu Kim,Sun Bo Shim,Su Hae Lee,Ji Soon Sin,Chang Jun Bae,Byoung Chun Lee,Jin Hee Park,Se Heon Lee,Jung Sik Cho,Hyoung Jin Kim,Byoung Cheo 한국실험동물학회 2007 Laboratory Animal Research Vol.23 No.3
It has been required to manage the laboratory animals with systemic and scientific manner and to develop the animal models for human diseases, according to the development of new drugs based on the research of gene function and irredeemable diseases activated by National Dynamic Project of 21th Century on Life and Health. It is also necessary to accredit with high quality of laboratory animals for evaluating the safety and validity of foods and drugs, which are directly connected to human health. The aim of this study was to search current status on genetically engineered animals in order to enhance the scientific trusts of these animals to advanced level, and thus providing the book guiding us how to manage and breed the genetically engineered animals. To accomplish this, 107 researchers were selected to ask for current status of genetic engineered animals to 35 questions including the area of management, patent, and law-regulation. We concluded that (ⅰ) there are the total of 146 genetically engineered animals and the total of 29 patents in the country, (ⅱ) the 64 different embryos from mouse, pig, dog, and wolf are stocked, and (ⅲ) it is being prepared to publish a guide book on the basis of these results. Thus, these results raised a possibility that guide book provides a good opportunity to experts acting in the field of evaluating toxicants and of testing drugs as a guideline. It is also possible to use as fundamental materials to establish national policy on the laboratory and genetic engineered animals, and to generate Laboratory Animal Law, which is being review by members of National Assembly.
Distribution and Seasonal Fluctuation of Bacteria Isolated from Mice and Rats
Chuel Kyu Kim,Sun Bo Shim,Jong Kun Seo,Mee Kyung Jang,Seung Wan Jee,Su Hae Lee,Chang Jun Bae,Jin-Ho Kang,Jong-Min Woo,Ho il Kang,Byoung Guk Kim,Jung Sik Cho 한국실험동물학회 2009 Laboratory Animal Research Vol.25 No.4
Bacterial pathogens can affect the experiment data by causing side immune responses. This study aimed to survey the status of laboratory animal quality for major suppliers and research institutes on a national scale, and also the distribution of respiratory and intestinal organ by the turning of the season. We monitored each organ from 738 mice and rats which are being distributed by 34 major institutes in Korea, taken 1,616 isolates including 857 (94.90%) and 759 isolates (97.31%), respectively, with VITEK and 16S rRNA sequence. The 945 (56.15%) and 671 (39.87%) of 1,616 isolates exhibited in respiratory organs and intestinal organs, respectively. Aerococcus viridans, Aeromonas salmonicida, Dermacoccus nishinomiyaensis, Kocuria rosia, Leucomostoc pseudomesenteroides, Micrococcus luteus, Sphingomonas paucimobilis, Staphylococcus lentus, Staphylococcus xylosus and Streptococcus parasanguinis were especially isolated in only respiratory organ. The microbial flora which belong to same species and genuses also distributed higher in autumn than in spring. Proteus vulgaris showed mainly in spring, while Sphigomonas paucimobilis, Micrococcus luteus, Leclercia adecarboxylate, and Kocuria rosea in autumn. Paenibacillus polymyxa, Granulicatella elegans, Granulicatella adiacens, Enterobacter cloacae, Brevibacillus choshinensis, Bacillus firmus, Bacillus circulans, Acinetobacter baumannii, Acromobacter denitrificans were specifically distributed in spring, and Streptococcus pneumoniae, Sphingomonas thalpophilum, Pasteurella canis, Micrococcus lylae, Brucella meltensis and Salmonella genus showd in autumn. These result suggested that composition and seasonal fluctuation of bacteria will serve as basic information for the improvement of domestic laboratory animal quality.
Animal selection and use in the 3R policy
김철규 ( Chuel Kyu Kim ) 한국동물실험대체법학회 2007 한국동물실험대체법학회 학술대회집 Vol.2007 No.1
Laboratory animals are used for regulatory testing to assess the safety, efficacy, and/or potential adverse health effects of a new chemicals and products such as vaccine, medicines, food additives, pesticides, and industrial chemicals. Testing results are used for risk assessment decisions intended to safeguard human and animal health. However, chemical toxicity and vaccine testing can cause injury, disease, and mortality involving significant pain and distress. Alleviation of pain and distress in animals during testing is problematic because regulation allow treatment only if the treatment does not interfere with study. Traditional approaches to reduction (e.g. improving experimental design) are being supplemented with complementary approaches such as the use of tier testing to eliminate some chemicals prior to in vivo testing. The development and implementation of alternatives to animal use include serological approaches, in vitro antigen quantification tests, the use of humane endpoints, and application of the principles of good laboratory animal practice. And full performance of the rules of good manufacturing practice and quality assurance would allow the application of a consistency approach to quality control of conventionally produced vaccines. Further progress in reducing animal pain and distress resulting from regulatory testing is expected as scientific and technological advances are incorporated into testing procedures and strategies. And further deceases in animal use will stem from international harmonization and coordination of testing programs.
Development and Characterization of New Animal Model for Alzheimer`s Disease
( Dae Y. Hwang ),( Yong Kyu Kim ),( Chuel Kyu Kim ),( Bung Guk Kim ),( Sun B. Shim ),( Seung W. Jee ),( Su H. Lee ),( Ji Soon Sin ),( Chang Jun Bae ),( Byoung Chun Lee ),( Su Jin Seo ),( Jung Sik Cho 한국응용약물학회 2007 학술대회 Vol.2007 No.1