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Development of Theragnostic Tool Using NIR Fluorescence Probe Targeting Mitochondria in Glioma Cells
Chu, Yeonjeong,Shin, Min Chul,Sung, June,Park, Jongmin,Kim, Eunha,Lee, Sanghee American Chemical Society 2019 Bioconjugate chemistry Vol.30 No.6
<P>Because mitochondria are essential organelles for regulating energy homeostasis and intrinsic apoptosis, the perturbation of mitochondrial functions has been considered as an anticancer treatment. In this study, a new near-infrared (NIR) fluorescent probe, SiR-Mito11 was developed as a theragnostic agent for brain tumor by targeting mitochondria. SiR-Mito11 exhibited potential anticancer activity against glioma cells but tolerance in normal neuronal cells. We further confirmed that the selective accumulation of SiR-Mito11 in glioma cells disrupted mitochondria membrane potential, followed by apoptotic cell death.</P> [FIG OMISSION]</BR>
A New Infrared Probe Targeting Mitochondria via Regulation of Molecular Hydrophobicity
Sung, June,Rho, Jun Gi,Jeon, Gyeong G.,Chu, Yeonjeong,Min, Jun Sik,Lee, Sanghee,Kim, Jong H.,Kim, Wook,Kim, Eunha American Chemical Society 2019 Bioconjugate chemistry Vol.30 No.1
<P>Herein, we developed a near-infrared (NIR) fluorescent probe for mitochondrial staining based on the NIR fluorochrome, silicon-rhodamine. The hydrophobicity of the fluorescent core was systematically modified by conjugation with 10 different commercial amines. The resulting fluorescent compounds exhibited similar photophysical properties but diverse hydrophobicity. We identified the optimal level of hydrophobicity associated with high mitochondrial targeting efficiency. In particular, the SiR-Mito 8 probe provided excellent mitochondrial staining and successfully differentiated the live Hep3B cancer cells from normal L02 cells <I>in vitro</I>.</P> [FIG OMISSION]</BR>