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1
Synergistic cooperation and crosstalk between MYD88L265P and mutations that dysregulate CD79B and surface IgM

Wang, James Q.,Jeelall, Yogesh S.,Humburg, Peter,Batchelor, Emma L.,Kaya, Sarp M.,Yoo, Hee Min,Goodnow, Christopher C.,Horikawa, Keisuke The Rockefeller University Press 2017 The Journal of experimental medicine Vol.214 No.9
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CD79B and MYD88 mutations are frequently and simultaneously detected in B cell malignancies. It is not known if these mutations cooperate or how crosstalk occurs. Here we analyze the consequences of CD79B and MYD88L265P mutations individually and combined in normal activated mouse B lymphocytes. CD79B mutations alone increased surface IgM but did not enhance B cell survival, proliferation, or altered NF-κB responsive markers. Conversely, B cells expressing MYD88L265P decreased surface IgM coupled with accumulation of endoglycosidase H–sensitive IgM intracellularly, resembling the trafficking block in anergic B cells repeatedly stimulated by self-antigen. Mutation or overexpression of CD79B counteracted the effect of MYD88L265P. In B cells chronically stimulated by self-antigen, CD79B and MYD88L265P mutations in combination, but not individually, blocked peripheral deletion and triggered differentiation into autoantibody secreting plasmablasts. These results reveal that CD79B and surface IgM constitute a rate-limiting checkpoint against B cell dysregulation by MYD88L265P and provide an explanation for the co-occurrence of MYD88 and CD79B mutations in lymphomas.
2
Two Waves of T Cell Negative Selection in the Thymus: Why?

Stephen R. Daley,Daniel Y. Hu,Jin Y. Yap,Matthieu Rousseau,Eric Boilard,Christopher C. Goodnow 한국실험동물학회 2014 한국실험동물학회 학술발표대회 논문집 Vol.2014 No.8
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3
Identification of Novel Regulators of B Cell Development and Function Using ENU Mutagenesis

Anselm Enders,Mehmet Yabas,Lisa A Miosge,Alanna Short,Yovina Sontani,Hannes Bergmann,Belinda Whilttle,Nadine Bartel,T. Daniel Andrews,Matthew A Field,Yafei Zhang,Edward M Bertram,Christopher C Goodnow 한국실험동물학회 2014 한국실험동물학회 학술발표대회 논문집 Vol.2014 No.8
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4
Linking Causal Relationships between Genes and Phenotypes of the Immune System Through Large Scale ENU Mutagenesis of the Mammalian Genome

Edward M Bertram,Lisa A Miosge,Yovina Sontani,Belinda Whittle,Anna Palkova,T. Daniel Andrews,Matthew A Field,Yafei Zhang,Anselm Enders,Christopher C. Goodnow 한국실험동물학회 2014 한국실험동물학회 학술발표대회 논문집 Vol.2014 No.8
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